Results 81 to 90 of about 55,926 (239)

The tRNA epitranscriptomic landscape and RNA modification enzymes in Vibrio cholerae.

PLoS Genetics
Transfer RNAs (tRNAs) are central to protein synthesis, ensuring precise decoding of the genetic code by delivering aminoacids to the ribosome. Among all RNA species, tRNAs are the most heavily and diversely modified, with modifications playing critical ...
Léo Hardy, Virginie Marchand, Valérie Bourguignon, Quentin Thuillier, Cathy Dias, Evelyne Krin, Louna Fruchard, Dan Bar Yaacov, Didier Mazel, Yuri Motorin, Zeynep Baharoglu   +10 more
doaj   +1 more source

Membrane modification by arginyl tRNA [PDF]

FEBS Letters, 1976
Kaji, Hideko, Rao, Prema
openaire   +2 more sources

Current Challenges of Transcription Compartmentalization Research

Advanced Science, EarlyView.
Transcription factors, coactivators, and RNA polymerase II assemble into transcription compartments ranging from small, defined complexes to liquid‐like condensates. This review unifies these seemingly competing descriptions along a single continuum and asks what these compartments have been shown to do, and what they have not, revealing that the most ...
Thomas Quail, Sina Wittmann
wiley   +1 more source

Glutathione‐Responsive Acyl‐Modifications for Targeted RNA Decaging and Prolonged Protein Synthesis

Angewandte Chemie, EarlyView.
The self‐immolation of disulfide‐based mRNA modifications in response to endogenous glutathione (GSH) promotes a gradual release of translatable mRNA within the cell, leading to improved nuclease resistance, tunable release properties, and a significant increase (up to 600%) of target protein production over time. This strategy offers an exciting proof
Mary E. Flood, Sathishkumar Kurusamy, Mark Berney, C. Mark Smales, Elizabeth M. Topp, Joanna F. McGouran, Steven Ferguson   +6 more
wiley   +2 more sources

A Panel of Circulating Exosomal sncRNAs Associated With Lung Cancer Risk up to 10 Years in Advance

Advanced Science, EarlyView.
Lung cancer is often diagnosed too late, and current screening overlooks many people at risk. In a long‐term study of smokers, a panel of small non‐coding RNAs carried in blood exosomes signals elevated lung cancer risk up to ten years before diagnosis, pointing toward a blood‐based tool for earlier risk detection.
Zhuokun Feng, Masaki Nasu, Ayman Abdul‐Ghani, Yu Chen, Shaoqiu Chen, Isam Mohd Ibrahim, Hanqiu Zhang, Lauren Higa, Zitong Gao, Hua Yang, Raphael Bueno, Loïc Le Marchand, Youping Deng   +12 more
wiley   +1 more source

Isosteric Engineering of Enzymes: Overcoming Activity–Stability Trade‐Offs by Site‐Selective CH → N Substitutions

Angewandte Chemie, EarlyView.
Coupling biosynthetic noncanonical amino acid production with genetic code expansion enables site‐specific incorporation of azatryptophans into PET‐degrading enzymes (PETases). By isosteric single‐atom editing of a conserved tryptophan, AzaPETases break the activity–stability trade‐off, delivering higher catalytic efficiency at elevated temperature and
Elwy H. Abdelkader, Haocheng Qianzhu, Gottfried Otting, Thomas Huber   +3 more
wiley   +2 more sources

The Emerging Field of Epitranscriptomics in Neurodevelopmental and Neuronal Disorders

Frontiers in Bioengineering and Biotechnology, 2018
Analogous to DNA methylation and histone modifications, RNA modifications represent a novel layer of regulation of gene expression. The dynamic nature and increasing number of RNA modifications offer new possibilities to rapidly alter gene expression ...
Margarita T. Angelova, Dilyana G. Dimitrova, Nadja Dinges, Tina Lence, Lina Worpenberg, Clément Carré, Jean-Yves Roignant   +6 more
doaj   +1 more source

The conformation of tRNA genes

FEBS Letters, 1993
It has been suggested that eukaryotic tRNA genes might adopt a higher order stem and loop structure to facilitate transcription by interaction of their variably spaced intragenic promoter blocks. Using sodium bisulphite, which reacts specifically with cytosine residues in single‐stranded nucleic acids, no deamination of C in the TTCGAA sequence of the ...
McLaren, A., Gonos, E.S., Carr, T., Goddard, J.P.   +3 more
openaire   +2 more sources

AARS1‐Mediated RUNX3 K193 Lactylation Enhances the Activation and Cytotoxicity of CD8+T Cells in Smoking‐Related Emphysema

Advanced Science, EarlyView.
Exposure to CS causes an elevation of AARS1 levels, which increases the levels of RUNX3 lactylation at the K193 site and increases protein levels of RUNX3 through inhibition of autolysosomal degradation. Elevated RUNX3 levels promote CD8+T cell activation and augment their cytotoxicity, which induces alveolar epithelial cell death and facilitates the ...
Ying Zhu, Jiaheng Lin, Yifan Li, Qiaoqiao Zhou, Min Yu, Cheng Cheng, Kang Chang, Dang Lin, Tao Bian, Yan Wu, Lu Lu, Haibo Xia, Qizhan Liu   +12 more
wiley   +1 more source

Phylogenomic insights into the genus Tulipa (Liliaceae): Taxonomy, evolution, and biogeography

American Journal of Botany, EarlyView.
Abstract Premise Tulips are one of the best‐known geophytes, but their taxonomy remains convoluted and their evolutionary history poorly understood. Here, we used plastid genomes to identify some issues with current classification, understand the diversification history of the genus, and identify potential species linked to historical cultivation ...
Brett Wilson, Maarten J. M. Christenhusz, Nathanael Walker‐Hale, Natalya Beshko, Mariyo Boboev, Colin Clubbe, Davron Dekhkonov, Aibek Dolotbakov, Mehmet Firat, Thomas Freeth, Sjaak de Groot, Avni Hajdari, Georgy A. Lazkov, Ormon Sultangaziev, Komiljon S. Tojibaev, Ben J. M. Zonneveld, Kaiyrkul T. Shalpykov, Samuel F. Brockington   +17 more
wiley   +1 more source