Emerging Issues on Tropane Alkaloid Contamination of Food in Europe [PDF]
Toxins, 2023 The occurrence of tropane alkaloids (TAs), toxic plant metabolites, in food in Europe was studied to identify those TAs in food most relevant for human health. Information was extracted from the literature and the 2016 study from the European Food Safety
Monique de Nijs +4 more
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Biotechnological Approaches on Engineering Medicinal Tropane Alkaloid Production in Plants [PDF]
Frontiers in Plant Science, 2022 Hyoscyamine and scopolamine, belonging to medicinal tropane alkaloids (MTAs), are potent anticholinergic drugs. Their industrial production relies on medicinal plants, but the levels of the two alkaloids are very low in planta.
Haiyue Gong +5 more
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Enhancing Tropane Alkaloid Production Based on the Functional Identification of Tropine-Forming Reductase in Scopolia lurida, a Tibetan Medicinal Plant [PDF]
Frontiers in Plant Science, 2017 Scopolia lurida, a native herbal plant species in Tibet, is one of the most effective producers of tropane alkaloids. However, the tropane alkaloid biosynthesis in this plant species of interest has yet to be studied at the molecular, biochemical, and ...
Kaihui Zhao +13 more
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Effects of Water Availability in the Soil on Tropane Alkaloid Production in Cultivated Datura stramonium [PDF]
Metabolites, 2019 Background: different Solanaceae and Erythroxylaceae species produce tropane alkaloids. These alkaloids are the starting material in the production of different pharmaceuticals.
Abigail Moreno-Pedraza +4 more
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Effect of silver nanoparticles on tropane alkaloid production of transgenic hairy root cultures of Hyoscyamus muticus L. and their antimicrobial activity [PDF]
Scientific Reports, 2023 The utilization of nanotechnology and biotechnology for enhancing the synthesis of plant bioactive chemicals is becoming increasingly common. The hairy root culture technique can be used to increase secondary metabolites such as tropane alkaloids ...
Aisha M. Abdelkawy +10 more
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Revealing evolution of tropane alkaloid biosynthesis by analyzing two genomes in the Solanaceae family [PDF]
Nature Communications, 2023 Tropane alkaloids (TAs) are synthesized by some species in Solanaceae. Here, the authors assemble the genomes of two representative TAs producing species, show that gene loss shapes uneven distribution of TAs in Solanaceae, and identify a cytochrome P450
Fangyuan Zhang +17 more
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A three-sided story: a biosystematic revision of genus Datura reveals novel tropane alkaloids for the first-time in certain species [PDF]
Frontiers in Plant ScienceIntroductionDatura, long considered an medicinal plant, represents a prospective source for discovering novel drugs for modern medicine. The Egyptian flora encompasses six Datura genotypes, including D. innoxia, D. ferox, D.
Abeer Al-Andal +8 more
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The high production of tropane alkaloids in hairy roots of Hyoscyamus reticulatus L. elicited by ZnO NPs in a bioreactor condition [PDF]
Scientific ReportsChemical synthesis issue of tropane alkaloids and their lowest production rate along with their extraction costs has made use of new methods necessary to produce valuable pharmaceutical compounds.
Sahar Alizadeh +3 more
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Nature Communications, 2022 Cocaine is a tropane alkaloid produced by Erythroxylum novogranatense. Here the authors identify two polyketide synthases involved in cocaine biosynthesis and provide insight into the parallel evolution of these enzymes in tropane alkaloids-producing ...
Tian Tian +9 more
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Frontiers in Plant Science, 2023 Anisodus tanguticus is a valuable plant for extracting tropane alkaloids. However, the mechanisms by which plant microbiome mediate the accumulation of tropane alkaloids in Anisodus tanguticus are still not well understood. In this study, we collected 55
Bo Wang +10 more
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