A Case of Belladonna Poisoning With Late-Onset Reappearance of Anticholinergic Toxicity. [PDF]
Clin Case RepOn day 1, blood concentrations of atropine and scopolamine were extremely low, whereas urinary concentrations were elevated, suggesting rapid urinary excretion. Subsequently, urinary concentrations decreased; however, at symptom recurrence, the blood atropine concentration increased, suggesting redistribution into the bloodstream. ABSTRACT In a patient
Hayashi T +9 more
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Scientific Reports, 2021 Tropane alkaloids and terpenoids are widely used in the medicine and pharmaceutic industry and evolved as chemical defenses against herbivores and pathogens in the annual herb Datura stramonium (Solanaceae).
I. M. De-la-Cruz +8 more
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Tropane and related alkaloid skeletons via a radical [3+3]-annulation process
Communications Chemistry, 2022 N-arylated bicyclic alkaloid skeletons are attractive scaffolds for medicinal chemistry, but aren’t conveniently accessible via the classical Robinson tropane synthesis.
Eloïse Colson +6 more
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Frontiers in Plant Science, 2022 Dendrobium officinale is both a traditional herbal medicine and a plant of high ornamental and medicinal value. Alkaloids, especially terpenoid indole alkaloids (TIAs), with pharmacological activities are present in the tissues of D. officinale. A number
Chunyan Jiao +8 more
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Tropine forming tropinone reductase gene from Withania somnifera (Ashwagandha): biochemical characteristics of the recombinant enzyme and novel physiological overtones of tissue-wide gene expression patterns. [PDF]
PLoS ONE, 2013 Withania somnifera is one of the most reputed medicinal plants of Indian systems of medicine synthesizing diverse types of secondary metabolites such as withanolides, alkaloids, withanamides etc. Present study comprises cloning and E.
Amit Kumar Kushwaha +5 more
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Application of recombinant DNA technology to studies on plant secondary metabolism [PDF]
, 2001 This review which is concerned with the application of recombinant DNA technology to studies on plant secondary metabolism, presents the more common plant transformation strategies and shows how these genetic approaches are being used in attempts to ...
Yeoman, Michael M., Zárate, Rafael
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Phytochemical Analysis of Veratrum Alkaloids in Medicinal Veratrum Globules Using High-Performance Liquid Chromatography Coupled With Tandem Mass Spectrometry. [PDF]
Biomed ChromatogrABSTRACT Veratrum L. species have been used in traditional medicine for centuries due to their bioactive properties, yet they also contain toxic steroid alkaloids that pose potential health risks when present in herbal preparations. Reliable analytical approaches are therefore essential to ensure product safety, protect consumer health and assess ...
Siegle J, Pietsch J.
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Production of tropane alkaloids in Hyoscyamus niger (black henbane) hairy roots grown in bubble-column and spray bioreactors [PDF]
, 2013 Hairy root cultures of Hyoscyamus niger were cultivated in shake-flasks, a bubble-column bioreactor and a hybrid bubble-column/spray bioreactor and evaluated for alkaloid production.
Adam Kokotkiewicz +4 more
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BMC Genomics, 2021 Background Datura stramonium (Jimsonweed) is a medicinally and pharmaceutically important plant in the nightshade family (Solanaceae) known for its production of various toxic, hallucinogenic, and therapeutic tropane alkaloids.
Alex Rajewski +3 more
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Enhanced production of tropane alkaloids in transgenic Scopolia parviflora hairy root cultures over-expressing putrescine N-methyl transferase (PMT) and hyoscyamine-6β-hydroxylase (H6H) [PDF]
, 2011 Scopolia parviflora adventitious roots were metabolically engineered by co-expression of the two gene putrescine N-methyl transferase (PMT) and hyoscyamine-6β-hydroxylase (H6H) cDNAs with the aid of Agrobacterium rhizogenes.
Choi, M.S. +8 more
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