Nature Communications, 2022 Cocaine is a tropane alkaloid produced by Erythroxylum novogranatense. Here the authors identify two polyketide synthases involved in cocaine biosynthesis and provide insight into the parallel evolution of these enzymes in tropane alkaloids-producing ...
Tian Tian +9 more
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Metabolites, 2019 Background: different Solanaceae and Erythroxylaceae species produce tropane alkaloids. These alkaloids are the starting material in the production of different pharmaceuticals.
Abigail Moreno-Pedraza +4 more
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Human acute exposure assessment to tropane alkaloids [PDF]
EFSA Journal, 2018 European Food Safety Authority (EFSA) +3 more
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Application of recombinant DNA technology to studies on plant secondary metabolism [PDF]
, 2001 This review which is concerned with the application of recombinant DNA technology to studies on plant secondary metabolism, presents the more common plant transformation strategies and shows how these genetic approaches are being used in attempts to ...
Yeoman, Michael M., Zárate, Rafael
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Production of tropane alkaloids in Hyoscyamus niger (black henbane) hairy roots grown in bubble-column and spray bioreactors [PDF]
, 2013 Hairy root cultures of Hyoscyamus niger were cultivated in shake-flasks, a bubble-column bioreactor and a hybrid bubble-column/spray bioreactor and evaluated for alkaloid production.
Adam Kokotkiewicz +4 more
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Tropane alkaloids and calystegines as chemotaxonomic markers in the Solanaceae
Anais da Academia Brasileira de Ciências, 2015 This study assessed the occurrence and distribution of tropane alkaloids and calystegines in genera of the family Solanaceae to identify patterns of distribution and make evolutionary inferences.
Aline G.S. Pigatto +3 more
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Enhanced production of tropane alkaloids in transgenic Scopolia parviflora hairy root cultures over-expressing putrescine N-methyl transferase (PMT) and hyoscyamine-6β-hydroxylase (H6H) [PDF]
, 2011 Scopolia parviflora adventitious roots were metabolically engineered by co-expression of the two gene putrescine N-methyl transferase (PMT) and hyoscyamine-6β-hydroxylase (H6H) cDNAs with the aid of Agrobacterium rhizogenes.
Choi, M.S. +8 more
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Scientific Reports, 2023 The utilization of nanotechnology and biotechnology for enhancing the synthesis of plant bioactive chemicals is becoming increasingly common. The hairy root culture technique can be used to increase secondary metabolites such as tropane alkaloids ...
Aisha M. Abdelkawy +10 more
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Report on the 2016 Proficiency Test of the European Union Reference Laboratory for Mycotoxins for the Network of National Reference Laboratories: Determination of tropane alkaloids in tea and herbal infusions [PDF]
, 2017 Tropane alkaloids (TAs) are toxins found in a wide variety of plant species growing in mild climates. The most well-known are Datura, Atropa and Hyoscyamus sp., belonging to the Solanaceae family.
BRATINOVA STEFANKA +4 more
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Scientific Reports, 2021 Tropane alkaloids and terpenoids are widely used in the medicine and pharmaceutic industry and evolved as chemical defenses against herbivores and pathogens in the annual herb Datura stramonium (Solanaceae).
I. M. De-la-Cruz +8 more
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