Results 111 to 120 of about 109,495 (390)

Human trophoblast invasion: new and unexpected routes and functions

Histochemistry and Cell Biology, 2018
Until recently, trophoblast invasion during human placentation was characterized by and restricted to invasion into uterine connective tissues and the uterine spiral arteries.
G. Moser, Karin Windsperger, J. Pollheimer, S. D. S. de Sousa Lopes, B. Huppertz   +4 more
semanticscholar   +1 more source

Inhibitor of DNA Binding Protein 2 (ID2) Mediates the Anti-Proliferative and Pro-Differentiation Effects of Insulin-like Growth Factor-1 (IGF-1)

Life
In preeclampsia (PE), impaired trophoblast proliferation and differentiation are thought to cause abnormal placentation and subsequent clinical manifestations of the disease, i.e., hypertension, proteinuria, and end-organ damage.
Rebecca Ssengonzi, Yuye Wang, Jiayi Zhou, Yukako Kayashima, W. H. Davin Townley-Tilson, Balaji Rao, Qing Ma, Nobuyo Maeda-Smithies, Feng Li   +8 more
doaj   +1 more source

Protocol for culturing the endocrine junctional zone of the mouse placenta in serum-free medium

STAR Protocols, 2023
Summary: The lack of a suitable explant culture system restricts the study of factors secreted by the mouse placenta into maternal circulation. Here, we present a protocol for culturing the endocrine junctional zone of the mouse placenta, free from the ...
Hong Wa Yung, Graham J. Burton, D. Stephen Charnock-Jones   +2 more
doaj  

A network of transient domains for breaking symmetry during anterior–posterior axis formation in the porcine embryo

Developmental Dynamics, EarlyView.
Abstract Breaking radial symmetry for anterior–posterior axis formation is one of the key developmental steps of vertebrate gastrulation and is established through a succession of transient domains defined by morphology or gene expression. Three such domains were interpreted recently in the rabbit to be part of a “three‐anchor‐point model” for axis ...
Ruben Plöger, Nikoloz Tsikolia, Christoph Viebahn   +2 more
wiley   +1 more source

CircTRNC18 inhibits trophoblast cell migration and epithelial–mesenchymal transition by regulating miR-762/Grhl2 pathway in pre-eclampsia

RNA Biology, 2019
Dysfunctions of epithelial–mesenchymal transition (EMT)-regulated cell migration and invasion have been involved in the pathogenesis of pre-eclampsia (PE). However, the role of circRNAs in EMT of PE has not been widely investigated.
Xue-Yan Shen, Lili Zheng, Jing Huang, Hongfang Kong, Yanxiang Chang, F. Wang, H. Xin   +6 more
semanticscholar   +1 more source

Plac1 Expression Pattern at the Mouse Fetomaternal Interface and Involvement in Trophoblast Differentiation

Cellular Physiology and Biochemistry, 2017
Background/Aims: It is well known that Plac1 is a placenta-specific gene; however, its spatiotemporal expression pattern and exact role at t h e mouse fetomaternal interface r e m a i n s unclear. Methods: In situ hybridization (ISH) was used to localize
Yanli Gu, Junhui Wan, Lv Yao, Nan-Ni Peng, Wen-Lin Chang   +4 more
doaj   +1 more source

Decidual Macrophages Are Significantly Increased in Spontaneous Miscarriages and Over-Express FasL [PDF]

, 2012
Decidual macrophages (DM) are the second most abundant population in the fetal-maternal interface. Their role has been so far identified as being local immuno-modulators favoring the maternal tolerance to the fetus.
Angioni, Antonis Makrigiannakis, Barnea, Birgit Bayer, Borges, Chieppa, Dace, Darius Dian, David Anz, Devaraj, Dockrell, Gordon, Gustafsson, Heikkinen, Houser, Iordanis Navrozoglou, Julia Knabl, Klaus Friese, Macklon, Makrigiannakis, Mills, Minas, Miwa, Mizuno, Munn, Nagamatsu, Nagata, Parhar, Pestka, Piccinni, Quack, Renaud, Sabine Guenther, Sabine Heublein, Saito, Sica, Thomas Vrekoussis, Udo Jeschke, Vassiliadou, Warning, Wongweragiat, Yagel   +41 more
core   +2 more sources

Hypertensive pregnancy disorder, an under‐recognized women specific risk factor for heart failure?

European Journal of Heart Failure, Volume 27, Issue 3, Page 459-472, March 2025.
Hypertensive disorders of pregnancy as a risk factor for heart failure. BMI, body mass index; CV, cardiovascular; CVD, cardiovascular disease; HELLP, haemolysis, elevated liver enzymes, low platelet count. Abstract During pregnancy, the maternal cardiovascular (CV) system undergoes major haemodynamic alterations ensuring adequate placental perfusion ...
Chahinda Ghossein‐Doha, Basky Thilaganathan, Arthur Jason Vaught, Joan E. Briller, Jolien W. Roos‐Hesselink   +4 more
wiley   +1 more source

Vascular dysfunction in women with recurrent pregnancy loss: Possible association with antiphospholipid antibodies

International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 206-214, April 2025.
Abstract Objective Antiphospholipid antibodies (aPL) are recognized to have a pivotal role in recurrent pregnancy loss (RPL) and cardiovascular disease. Therefore, we assessed the vascular function of women with RPL and examined the association with each type of aPL.
Titi Yang, Emi Okada, Maho Todoroki, Siyu Liu, Rukmali Athurupana, Kumie Kataoka, Chiaki Kashino, Takashi Mitsui, Toru Hasegawa, Yasuhiko Kamada, Hisashi Masuyama, Mikiya Nakatsuka   +11 more
wiley   +1 more source

Establishment and differentiation of long-term trophoblast organoid cultures from the human placenta

Nature Protocols, 2018
The human placenta is essential for successful reproduction. There is great variation in the anatomy and development of the placenta in different species, meaning that animal models provide limited information about human placental development and ...
M. Sheridan, R. Fernando, L. Gardner, M. Hollinshead, G. Burton, A. Moffett, M. Turco   +6 more
semanticscholar   +1 more source