Results 61 to 70 of about 40,342 (338)

Crosstalk Between Trophoblast and Macrophage at the Maternal-Fetal Interface: Current Status and Future Perspectives

Frontiers in Immunology, 2021
The immune tolerance microenvironment is crucial for the establishment and maintenance of pregnancy at the maternal-fetal interface. The maternal-fetal interface is a complex system containing various cells, including lymphocytes, decidual stromal cells,
Jinli Ding, Yan Zhang, Xiaopeng Cai, Lianghui Diao, Chaogang Yang, Jing Yang   +5 more
doaj   +1 more source

VE-cadherin enables trophoblast endovascular invasion and spiral artery remodeling during placental development

eLife, 2022
During formation of the mammalian placenta, trophoblasts invade the maternal decidua and remodel spiral arteries to bring maternal blood into the placenta.
Derek C Sung, Xiaowen Chen, Mei Chen, Jisheng Yang, Susan Schultz, Apoorva Babu, Yitian Xu, Siqi Gao, TC Stevenson Keller IV, Patricia Mericko-Ishizuka, Michelle Lee, Ying Yang, Joshua P Scallan, Mark L Kahn   +13 more
doaj   +1 more source

Pathogenesis of placentitis in the goat (Capra hircus) inoculated with Brucella abortus [PDF]

, 1985
A caprine model of ruminant brucellar placentitis was developed and used to determine the pathogenesis of placental infection and to characterize changes in trophoblasts infected with Brucella abortus.
Anderson, Timothy Dean
core   +2 more sources

Targeting Decidual CD16+ Immune Cells with Exosome‐Based Glucocorticoid Nanoparticles for Miscarriage

Advanced Science, EarlyView.
Exosome‐based nanoparticles (GC‐Exo‐CD16Ab) are designed to deliver glucocorticoids (GC) specifically to decidual CD16+ NK cells and macrophages. This targeted delivery effectively suppresses the cytotoxicity of decidual NK cells, inhibits M1 macrophage polarization, and modulates the decidual microenvironment.
Linlin Wang, Zhinang Yin, Yanqiong Shen, Gang Feng, Fangfang Dai, Dongyong Yang, Zhimin Deng, Jing Yang, Ruizhi Chen, Leifeng Yang, Xian Chen, Qing Sun, Chunyu Huang, Yanxiang Cheng, Hongbing Deng, Lianghui Diao, Longfei Li, Tailang Yin   +17 more
wiley   +1 more source

RITA Is Expressed in Trophoblastic Cells and Is Involved in Differentiation Processes of the Placenta

Cells, 2019
Preeclampsia (PE) remains a leading cause of maternal and perinatal mortality and morbidity worldwide. Its pathogenesis has not been fully elucidated and no causal therapy is currently available.
Julia Maria Wildner, Alexandra Friemel, Lukas Jennewein, Susanne Roth, Andreas Ritter, Cornelia Schüttler, Qi Chen, Frank Louwen, Juping Yuan, Nina-Naomi Kreis   +9 more
doaj   +1 more source

Palmitoleate Protects against Zika Virus-Induced Placental Trophoblast Apoptosis

Biomedicines, 2021
Zika virus (ZIKV) infection in pregnancy is associated with the development of microcephaly, intrauterine growth restriction, and ocular damage in the fetus.
Philma Glora Muthuraj, Aryamav Pattnaik, Prakash K. Sahoo, Md Torikul Islam, Asit K. Pattnaik, Siddappa N. Byrareddy, Corrine Hanson, Ann Anderson Berry, Stephen D. Kachman, Sathish Kumar Natarajan   +9 more
doaj   +1 more source

HLA gene expression is altered in whole blood and placenta from women who later developed preeclampsia [PDF]

, 2017
Preeclampsia is a multi-system disease that significantly contributes to maternal and fetal morbidity and mortality. In this study, we used a non-biased microarray approach to identify dysregulated genes in maternal whole blood samples which may be ...
Akehurst, Christine, Carty, David M., Delles, Christian, Freeman, Dilys J., McBride, Martin W., McClure, John D., Robinson, Scott W., Sharafetdinova, Lilya, Small, Heather Y.   +8 more
core   +1 more source

GRP78 Nanobody‐Directed Immunotoxin Activates Innate Immunity Through STING Pathway to Synergize Tumor Immunotherapy

Advanced Science, EarlyView.
A GRP78 nanobody‐directed immunotoxin suppresses cancer progression and metastasis by enhancing antitumor immunity via STING pathway activation, offering a pan‐cancer‐targeted approach and immunotherapy combination strategy. Abstract The lack of targetable antigens poses a significant challenge in developing effective cancer‐targeted therapies.
Huifang Wang, Runhua Zhou, Chengchao Xu, Lingyun Dai, Rui Hou, Liuhai Zheng, Chunjin Fu, Guangwei Shi, Jingwei Wang, Yang Li, Jinpeng Cen, Xiaolong Xu, Le Yu, Yilei Li, Jigang Wang, Qingfeng Du, Zhijie Li   +16 more
wiley   +1 more source

Mechanisms of Zika virus infection and neuropathogenesis [PDF]

, 2016
A spotlight has been focused on the mosquito-borne Zika virus (ZIKV) because of its epidemic outbreak in Brazil and Latin America, as well as the severe neurological manifestations of microcephaly and Guillain–Barré syndrome associated with infection. In
Coyne, Carolyn B, Diamond, Michael S, Hiscott, John, Muscolini, Michela, Olagnier, David   +4 more
core   +2 more sources

ZNHIT3 Regulates Translation to Ensure Cell Lineage Differentiation in Mouse Preimplantation Development

Advanced Science, EarlyView.
Box C/D snoRNP complex regulates protein translation. This study identifies ZNHIT3 as a key component of the complex and ensures normal protein expression, including transcription factors orchestrating cell fate commitment, during early mouse embryogenesis.
Guanghui Yang, Qiliang Xin, Jurrien Dean
wiley   +1 more source