Results 71 to 80 of about 43,593 (324)
Effects of estradiol on HIF-1α expression and trophoblast differentiation in first trimester villous explant cultures [PDF]
Obstetrics & Gynecology Science, 2018 ObjectiveThe purpose of this study was to investigate the effects of estradiol on the expression of hypoxia-inducible factor (HIF)-1α and the differentiation of trophoblasts in human first trimester villous explant cultures.MethodsVillous explant ...
Geum Joon Cho +7 more
doaj +1 more source
Biomolecules, 2023 Whilst S100P has been shown to be a marker for carcinogenesis, we have shown, in non-physio-pathological states, that its expression promotes trophoblast motility and invasion but the mechanisms explaining these cellular processes are unknown.
Tara Lancaster +4 more
doaj +1 more source
Hydrogel Confinement Strategies for 3D Cell Culture in Microfluidic Systems
Advanced Materials Technologies, EarlyView.Hydrogel confinement structures are key to organizing 3D cell cultures in microfluidic devices. This review classifies five structural strategies (micropillar, phaseguide, porous membrane, stepped‐height, and support‐free) and examines their trade‐offs alongside fabrication methods.
Soohyun Kim, Min Seok Lee, Sung Kyun Lee
wiley +1 more source
Immune Responses Potentially Involved in the Gestational Complications of Brucella Infection
Pathogens, 2023 Infection by Brucella species in pregnant animals and humans is associated with an increased risk of abortion, preterm birth, and transmission of the infection to the offspring.
Lucía Zavattieri +3 more
doaj +1 more source
Advanced Science, EarlyView.In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou +10 more
wiley +1 more source
Immunohistohemical evidences of pregnancy in uterine curettage tissue by the use of a double immunocytochemical staining technique using cytokeratin 7 and vimentin antibodies [PDF]
Vojnosanitetski Pregled, 2008 Background/Aim. Usual histopatological diagnosis of intrauterine pregnancy is made by demonstration of chorionic villi, but in the curettage tissue from intrauterine miscarriage they may not be present in all cases. The use of monoclonal antibody against
Trenkić Milan +5 more
doaj +1 more source
Diagnostics, 2023 As the prevalence of pregnancies with advanced maternal age increases, the risk of fetal chromosomal abnormalities is on the rise. Therefore, prenatal genetic screening and diagnosis have become essential elements in contemporary obstetrical care ...
Kirim Hong +6 more
doaj +1 more source
Advanced Science, EarlyView.PFOA exposure induces pregnancy loss by promoting glutaminolysis, which further causes ammonia accumulation in macrophages. Cellular ammonia retention results in damage to mitochondria and lysosomes, which leads to cell death eventually. Impaired lysosomes also decrease the secretion of the Cathepsin B (CTSB), and attenuate macrophage infiltration and ...
Yongbo Zhao +6 more
wiley +1 more source
Mouse models for preeclampsia: disruption of redox-regulated signaling [PDF]
, 2009 The concept that oxidative stress contributes to the development of human preeclampsia has never been tested in genetically-defined animal models. Homozygous deletion of catechol-Omethyl transferase (Comt-/-) in pregnant mice leads to human preeclampsia ...
A Malassine +51 more
core +4 more sources
Acta Medica International, 2022 Introduction: Clinically, all trophoblastic lesions are frequently combined under a broad spectrum of gestational trophoblastic diseases (GTDs) without the use of specific pathological terms.
B M Soumya +4 more
doaj +1 more source