Results 51 to 60 of about 54,779 (267)

Lipid Nanoparticle Co‐Delivery of mRNA and a Small Molecule Drug for Oral Cancer Chemoimmunotherapy

Advanced Materials, EarlyView.
Co‐encapsulation of p53 mRNA and the small molecule ciclopirox within a lipid nanoparticle yields an all‐in‐one chemoimmunotherapy for oral squamous cell carcinoma. The platform engages caspase‐driven apoptosis in cancer cells while repolarizing tumor‐associated macrophages, achieving tumor reduction in both p53‐susceptible and p53‐resistant models and
Marshall S. Padilla, Jacqueline J. Li, Qunzhou Zhang, Korey Patwari, Shihong Shi, Hannah M. Yamagata, Ryann A. Joseph, Briyanna N. Hymms, Sridatta V. Teerdhala, Emily Fitzgerald, Ori Z. Chalom, Kushol Gupta, Mohamad‐Gabriel Alameh, Drew Weissman, Anh D. Le, Michael J. Mitchell   +15 more
wiley   +1 more source

High-throughput diagnostic markers for foliar fungal disease resistance and high oleic acid content in groundnut

BMC Plant Biology
Background Foliar diseases namely late leaf spot (LLS) and leaf rust (LR) reduce yield and deteriorate fodder quality in groundnut. Also the high oleic acid content has emerged as one of the most important traits for industries and consumers due to its ...
Manish K. Pandey, Sunil S. Gangurde, Yaduru Shasidhar, Vinay Sharma, Sandip M. Kale, Aamir W. Khan, Priya Shah, Pushpesh Joshi, Ramesh S. Bhat, Pasupuleti Janila, Sandip K. Bera, Rajeev K. Varshney   +11 more
doaj   +1 more source

Genotyping-by-sequencing of three mapping populations for identification of candidate genomic regions for resistance to sterility mosaic disease in pigeonpea

Scientific Reports, 2017
Sterility mosaic disease (SMD) is one of the serious production constraints that may lead to complete yield loss in pigeonpea. Three mapping populations including two recombinant inbred lines and one F2, were used for phenotyping for SMD resistance at ...
Rachit K. Saxena, Sandip M. Kale, Vinay Kumar, Swathi Parupali, Shourabh Joshi, Vikas Singh, Vanika Garg, Roma R. Das, Mamta Sharma, K. N. Yamini, Anuradha Ghanta, Abhishek Rathore, C. V. Sameerkumar, K. B. Saxena, Rajeev K. Varshney   +14 more
doaj   +1 more source

Resolving Heterogeneity of Targeted Lipid Nanoparticles Through Solution‐Based Biophysical Analyses

Advanced Materials, EarlyView.
AF4‐UV‐DLS‐MALS‐SAXS resolves previously inaccessible targeted lipid nanoparticle (tLNP) subpopulations that differ in size, shape, and composition. Correlation of subpopulation‐resolved biophysical properties with in vivo RNA delivery reveals that targeted placental transfection is associated with distinct tLNP subpopulations rather than ensemble ...
Hannah C. Geisler, Hannah C. Safford, Ajay S. Thatte, Marshall S. Padilla, Elisa Battistini, Hannah M. Yamagata, Violet M. Ullman, Alex Chan, Benjamin E. Nachod, Anushka Agrawal, Maxwell B. Watkins, Jesse B. Hopkins, Andrew Tsourkas, Kushol Gupta, Michael J. Mitchell   +14 more
wiley   +1 more source

Genome-Wide Discovery and Deployment of Insertions and Deletions Markers Provided Greater Insights on Species, Genomes, and Sections Relationships in the Genus Arachis

Frontiers in Plant Science, 2017
Small insertions and deletions (InDels) are the second most prevalent and the most abundant structural variations in plant genomes. In order to deploy these genetic variations for genetic analysis in genus Arachis, we conducted comparative analysis of ...
Manish K. Vishwakarma, Sandip M. Kale, Manda Sriswathi, Talari Naresh, Yaduru Shasidhar, Vanika Garg, Manish K. Pandey, Rajeev K. Varshney, Rajeev K. Varshney   +8 more
doaj   +1 more source

Does backyard-keeping of native sows by smallholders in Quezon, Philippines, offer sustainability benefits compared to more intensive management of exotic sow breeds?

Journal of Agriculture and Rural Development in the Tropics and Subtropics, 2020
The present study in Quezon, Philippines, assessed the sustainability of small-scale production systems, based either on native or on exotic sow breeds, using different survey tools in a socio-economic approach. In two research periods, data sets with 49
Philipp C. Muth, Inga K. Pöhlmann, Sangeun Bae, Christoph Reiber, Orville L. Bondoc, Anne Valle Zárate   +5 more
doaj   +1 more source

Climate Change Threatens Micronutrient Density of European Winter Wheat

Advanced Science, EarlyView.
Micronutrients are vital for human health. Wheat is a major staple crop and a significant source of minerals and B‐vitamins. The impact of climate change on their content remains largely unknown. We evaluated micronutrient levels in European winter wheat grown under historical and projected climate conditions. Our findings indicate that future climates
Da Cao, Jennifer Michel, Eline Lorer, Markus Weinmann, Jacques Le Gouis, Claire Léon, Sibille Perrochon, David Alvarez, Vincent Leemans, Iñaki Balanzategui Guijarro, Jordi Moya Laraño, Sara Sánchez Moreno, Symanczik Sarah, Waibel Matthias, Hervé Vanderschuren, Cécile Thonar, Pierre Delaplace, Dominique Van Der Straeten   +17 more
wiley   +1 more source

Microbial consortium culture and vermi-composting technologies for recycling on-farm wastes and food production

International Journal of Recycling of Organic Waste in Agriculture, 2018
Purpose A study was conducted to characterize the ‘Madhyam culture’ (Excel Crop Care Limited.), an aerobic-composting microbial consortium culture, and understand composting dynamics, product quality and use in crop production vis-à-vis vermi-composting (
Girish Chander, Suhas P. Wani, S. Gopalakrishnan, Ankita Mahapatra, Swati Chaudhury, C. S. Pawar, Manoj Kaushal, A. V. R. Kesava Rao   +7 more
doaj   +1 more source

eQTL Meta‐Analysis Reveals Conserved and Population‐Specific Regulatory Variation Underlying Nutritional Trait Evolution and Domestication in Tomato

Advanced Science, EarlyView.
A comprehensive meta‐analysis of expression quantitative trait loci (eQTLs) across five diverse tomato populations reveals a high‐resolution atlas of transcriptional regulation and uncovers conserved and population‐specific regulatory architectures underlying fruit nutritional quality traits, including flavonoids, sugars, organic acids, carotenoids ...
Jiantao Zhao, Xin Wang, Jing Zhang, Ryan McQuinn, Je Min Lee, Itay Gonda, Ari Feder, Yimin Xu, Baike Wang, Qinghui Yu, Denise M. Tieman, Sanwen Huang, Harry Klee, James J. Giovannoni, Zhangjun Fei   +14 more
wiley   +1 more source

Genome‐Wide Association Study and RNA Sequencing Identify Candidate Genes Regulating Nitrogen Use Efficiency and Associated Traits in Sorghum (Sorghum bicolor (L.) Moench)

Food and Energy Security
Sorghum (Sorghum bicolor L. Moench) is a resilient cereal crop with remarkable adaptability to diverse environments. Nitrogen use efficiency (NUE) is critical for improving sorghum yields, resource utilization, livelihood security, and environmental ...
Srikanth Bollam, Laavanya Rayaprolu, Kirandeep Kaur Romana, Pradeep Ruperao, Sivasubramani Selvanayagam, Anil Kumar Vemula, Gopikrishna Adapala, Vinod Kumar Valluri, Prasad Bajaj, Abhishek Rathore, Damaris A. Odeny, Rakesh K. Srivastava, Santosh P. Deshpande, Rajeev Gupta   +13 more
doaj   +1 more source