Results 61 to 70 of about 54,779 (267)

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Reimagining landscape sustainability through integrated farming system models and policies under changing climate scenarios

Discover Sustainability
In the context of climate change, natural resource degradation, and decreasing farm and input productivity, there is an urgent need to redesign agricultural systems with the use of integrated, landscape-level approaches.
Gajanan L Sawargaonkar, S. Rakesh, Santosh Kale, Akash Paul, Ankit Kumar Shridhar, Dimple Karnam Thulasiram, Prasad Kamdi, V. PadmajaKaranam, Rajesh Pasumarthi, Rohan Khopade, Anantha KH, Shalander Kumar, Ramesh Singh, Mangi Lal Jat   +13 more
doaj   +1 more source

Two Routes to Land: Genomic Underpinnings of Parallel Aerial Egg Deposition in Aquatic Old‐World Pila and New‐World Pomacea (Ampullariidae)

Advanced Science, EarlyView.
Comparative genomics of Gondwana‐diverged Pila and Pomacea reveals parallel evolution of aerial oviposition. Convergent chromosomal rearrangements reshape regulatory landscapes within topologically associating domains. Lineage‐specific gene family expansions and viral‐derived perivitelline proteins (PV1) underpin desiccation resistance.
Yufei Zhou, Huawei Mu, Xueying Nie, Yue Gao, Hui Wang, Ling Fang, Tiangang Luan, Monthon Ganmanee, Jian‐Wen Qiu, Jin Sun, Jack Chi‐Ho Ip   +10 more
wiley   +1 more source

MFPD: A Multiple Fungal Pathogen Detection Pipeline Across Diverse Habitats

Advanced Science, EarlyView.
The MFPD pipeline integrates a comprehensive ITS reference database of fungal pathogens, optimized parameters, and algorithms tailored for both full‐length and subregion sequences that balance accuracy and computational efficiency; it enables high‐throughput, species‐level identification from amplicon sequencing data, supporting large‐scale ...
Yi Shen, Xinrun Yang, Jiabao Yu, Yaozhong Zhang, Tianjie Yang, Yang Gao, Xiaofang Wang, Alexandre Jousset, Waseem Raza, Fang‐Jie Zhao, Qirong Shen, Gaofei Jiang, Zhong Wei, Yangchun Xu   +13 more
wiley   +1 more source

Sustainable intensification in coconut for building system resilience and nutritional security of smallholders in Eastern India

npj Sustainable Agriculture
Coconut-based cropping systems are vital to the coastal rural economy, which faces challenges like declining soil fertility, low productivity, pest invasions, and climate change.
Rohan Khopade, Gajanan Sawargaonkar, Santosh Kale, Moses Davala, S. Rakesh, Susree Snigdha Das, RamVikas Verma, Kapil Raje, Ramesh Singh, M. L. Jat   +9 more
doaj   +1 more source

Inheritance of Resistance to Sorghum Shoot Fly, Atherigona soccata in Sorghum, Sorghum bicolor (L.) Moench

Frontiers in Plant Science, 2016
Host plant resistance is one of the major components to control sorghum shoot fly, Atherigona soccata. To understand the nature of gene action for inheritance of shoot fly resistance, we evaluated 10 parents, 45 F1’s and their reciprocals in replicated ...
Mohammed eRiyazaddin, Mohammed eRiyazaddin, Are Ashok Kumar, Rajendra S Munghate, Bhavanasi eRamaiah, Polavarapu B Kavi Kishor, Hari C Sharma   +6 more
doaj   +1 more source

ZDHHC18‐Mediated Palmitoylation of ORF3a Promotes SARS‐CoV‐2 Pathogenesis by Antagonizing TRIM16‐Mediated Ubiquitination and Proteasomal Degradation

Advanced Science, EarlyView.
Palmitoylation by ZDHHC18 blocks ORF3a K27‐linked ubiquitination mediated by TRIM16, thereby preventing its proteasomal degradation and strengthening viral pathogenesis. Targeting palmitoylation through a pharmacological inhibitor (2‐BP), a competitive inhibitory peptide (OPIP), or adenovirus‐mediated knockdown of ZDHHC18 expression presents a ...
Sidi Yang, Kun Li, Lihong Liu, Linsen Zeng, Qifeng Deng, Jiacheng Huang, Xiaoran Dong, Xin Wang, Jianwei Liang, Hongchao Liu, Hong Peng, Yuxin Lin, Xiaolu Xie, Yuzhen Ye, Tiefeng Xu, Zhaohuan Wang, Chun‐Mei Li, Deyin Guo   +17 more
wiley   +1 more source

Rapid Ragi: A speed breeding protocol for finger millet

Plant Methods
Background Climate change is gradually increasing demand for resilient, nutritious crops like finger millet or ragi. Ensuring food security requires researchers to develop improved and adapted cultivars rapidly.
Sobhan Sajja, Jwala Pranati, S. Shyamala, K. S. Vinutha, Ramya Reddy, Priyanka Joshi, Srinivasulu Pannem, P. Rakshit, Yashoda Jadhav, C. V. Sameer Kumar, Sean Mayes   +10 more
doaj   +1 more source

Genomics-assisted breeding for boosting crop improvement in pigeonpea (Cajanus cajan)

Frontiers in Plant Science, 2015
Pigeonpea is an important pulse crop grown predominantly in the tropical and sub-tropical regions of the world. Although pigeonpea growing area has considerably increased, yield has remained stagnant for the last six decades mainly due to the exposure of
Lekha ePazhamala, Rachit K Saxena, Vikas K Singh, CV eSameerkumar, Vinay eKumar, Pallavi eSinha, Kishan ePatel, Jimmy eObala, Jimmy eObala, Seleman R Kaoneka, Seleman R Kaoneka, P eTongoona, Hussein eShimelis, NVPR eGangarao, Damaris eOdeny, Abhishek eRathore, PS eDharmaraj, KN eYamini, Rajeev K Varshney, Rajeev K Varshney   +19 more
doaj   +1 more source

Heterojunction‐Engineered Mass Spectrometry Platform for Deciphering Serum Metabolic Fingerprints in Diagnosis of Respiratory Diseases

Advanced Science, EarlyView.
Hollow Co3O4/TiO2 heterojunctions are engineered for high‐throughput laser desorption/ionization mass spectrometry. The built‐in electric field drives efficient charge separation and photothermal conversion, while the hierarchical mesoporous network enables robust salt and protein tolerance.
Junyu Chen, Chaoqi Wang, Xi Yu, Yuming Jiang, Yijiao Qu, Huihui Fu, Yuyin Bu, Xiaoyong Zhang, Zongxiu Nie   +8 more
wiley   +1 more source