Tropoelastin Implants That Accelerate Wound Repair [PDF]
Advanced Healthcare Materials, 2018 AbstractA novel, pure, synthetic material is presented that promotes the repair of full‐thickness skin wounds. The active component is tropoelastin and leverages its ability to promote new blood vessel formation and its cell recruiting properties to accelerate wound repair.
Wojciech Chrzanowski +18 more
openaire +3 more sources
Physiological Reports, 2020 Pelvic organ prolapse (POP) decreases quality of life for many women, but its pathophysiology is poorly understood. We have previously shown that Lysyl oxidase‐like 1 knockout (Loxl1 KO) mice reliably prolapse with age and increased parity, similar to ...
Slater A. Jameson +8 more
doaj +1 more source
Elastogenic protein expression of a highly elastic murine spinal ligament: the ligamentum flavum. [PDF]
PLoS ONE, 2012 Spinal ligaments, such as the ligamentum flavum (LF), are prone to degeneration and iatrogenic injury that can lead to back pain and nerve dysfunction. Repair and regeneration strategies for these tissues are lacking, perhaps due to limited understanding
Jeffrey P Brown +3 more
doaj +1 more source
Targeted disruption of fibulin-4 abolishes elastogenesis and causes perinatal lethality in mice [PDF]
, 2006 Elastic fibers provide tissues with elasticity which is critical to the function of arteries, lungs, skin, and other dynamic organs. Loss of elasticity is a major contributing factor in aging and diseases.
Broekelmann, Thomas J +10 more
core +3 more sources
Decreased lung fibroblast growth factor 18 and elastin in human congenital diaphragmatic hernia and animal models. [PDF]
, 2007 International audienceRATIONALE: Lung hypoplasia in congenital diaphragmatic hernia (CDH) seems to involve impaired alveolar septation. We hypothesized that disturbed deposition of elastin and expression of fibroblast growth factor 18 (FGF18), an ...
Barlier-Mur, Anne-Marie +6 more
core +4 more sources
Elastic fiber assembly is disrupted by excessive accumulation of chondroitin sulfate in the human dermal fibrotic disease, keloid [PDF]
, 2009 Keloid is a fibrotic disease characterized by abnormal accumulation of extracellular matrix in the dermis. The keloid matrix contains excess collagen and glycosaminoglycans (GAGs), but lacks elastic fiber. However, the roles of these matrix components in
Ikeda, Mika +10 more
core +1 more source
Heparan sulfate affects elastin deposition in fibroblasts cultured from donors of different ages [PDF]
, 2012 Heparan sulfate (HS), due to its presence on the cell surface and in the extracellular milieu and its ability to modulate cell signaling, has a fundamental role in both physiological and pathological conditions.
ANNOVI, Giulia +7 more
core +1 more source
A potential role for endogenous proteins as sacrificial sunscreens and antioxidants in human tissues [PDF]
, 2015 Excessive ultraviolet radiation (UVR) exposure of the skin is associated with adverse clinical outcomes. Although both exogenous sunscreens and endogenous tissue components (including melanins and tryptophan-derived compounds) reduce UVR penetration, the
Abramoff +105 more
core +2 more sources
Mir-29 repression in bladder outlet obstruction contributes to matrix remodeling and altered stiffness. [PDF]
PLoS ONE, 2013 Recent work has uncovered a role of the microRNA (miRNA) miR-29 in remodeling of the extracellular matrix. Partial bladder outlet obstruction is a prevalent condition in older men with prostate enlargement that leads to matrix synthesis in the lower ...
Mari Ekman +5 more
doaj +1 more source
Trends in the design and use of elastin-like recombinamers as biomaterials [PDF]
, 2019 Producción CientíficaElastin-like recombinamers (ELRs), which derive from one of the repetitive domains found in natural elastin, have been intensively studied in the last few years from several points of view.
Acosta Rodríguez, Sergio +3 more
core +2 more sources