Arterial stiffening in western diet-fed mice is associated with increased vascular elastin, transforming growth factor-ß, and plasma neuraminidase [PDF]
, 2016 Consumption of excess fat and carbohydrate (Western diet, WD) is associated with alterations in the structural characteristics of blood vessels. This vascular remodeling contributes to the development of cardiovascular disease, particularly as it affects
Alvira +66 more
core +1 more source
Fibulin-4 is essential for maintaining arterial wall integrity in conduit but not muscular arteries [PDF]
, 2017 Homozygous or compound heterozygous mutations in fibulin-4 (FBLN4) lead to autosomal recessive cutis laxa type 1B (ARCL1B), a multisystem disorder characterized by significant cardiovascular abnormalities, including abnormal elastin assembly, arterial ...
Broekelmann, Thomas J +5 more
core +3 more sources
Plasma ion implantation enabled bio-functionalization of PEEK improves osteoblastic activity
APL Bioengineering, 2018 Slow appositional growth of bone in vivo is a major problem associated with polyether ether ketone (PEEK) based orthopaedic implants. Early stage promotion of osteoblast activity, particularly bone nodule formation, would help to improve contact between ...
Edgar A. Wakelin +4 more
doaj +1 more source
A novel tropoelastin-based resorbable surgical mesh for pelvic organ prolapse repair
Materials Today Bio, 2020 Pelvic organ prolapse is a common condition that affects 1 in 4 women across all age groups. It is mainly caused by vaginal birth injury and can be exacerbated by obesity and increased age.
B. Aghaei-Ghareh-Bolagh +8 more
doaj +1 more source
Structural studies of elastic fibre and microfibrillar proteins
Matrix Biology Plus, 2021 Elastic tissues owe their functional properties to the composition of their extracellular matrices, particularly the range of extracellular, multidomain extensible elastic fibre and microfibrillar proteins.
Mukti Singh +3 more
doaj +1 more source
Extracellular Matrix Molecules Facilitating Vascular Biointegration
Journal of Functional Biomaterials, 2012 All vascular implants, including stents, heart valves and graft materials exhibit suboptimal biocompatibility that significantly reduces their clinical efficacy.
Martin K.C. Ng +3 more
doaj +1 more source
Mir-29 repression in bladder outlet obstruction contributes to matrix remodeling and altered stiffness. [PDF]
PLoS ONE, 2013 Recent work has uncovered a role of the microRNA (miRNA) miR-29 in remodeling of the extracellular matrix. Partial bladder outlet obstruction is a prevalent condition in older men with prostate enlargement that leads to matrix synthesis in the lower ...
Mari Ekman +5 more
doaj +1 more source
Bioactive Materials, 2022 Intra-articular injection of mesenchymal stem cells (MSCs) is a promising strategy for osteoarthritis (OA) treatment. However, more and more studies reveal that the injected MSCs have poor adhesion, migration, and survival in the joint cavity.
Junjun Yang +15 more
doaj +1 more source
Influence of the architecture on the molecular mobility of synthetic fragments inspired from human tropoelastin [PDF]
, 2015 This work deals with the vibrational, thermal and dielectric characterization of a synthetic peptide (S4) released during the proteolysis of human tropoelastin. This peptide was shown to form amyloid-like fibers implied in neurodegenerative pathologies.
Bochicchio, Brigida +5 more
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Cultured Human Keratinocytes Express Tropoelastin
Journal of Investigative Dermatology, 1997 We detected elastin mRNA in cultured normal human keratinocytes by RNase protection assay. The content of elastin mRNA was estimated at approximately one-twentieth of that of cultured skin fibroblasts. Tropoelastin polypeptide with a molecular weight of 68 kDa was detected in the preparation of culture medium of normal human keratinocytes by western ...
Kajiya, Hiroyoshi +5 more
openaire +2 more sources