Results 141 to 150 of about 2,101 (172)
Domain structure of tropomodulin [PDF]
FEBS Journal, 2000 The structure of tropomodulin, the unique capping protein for the pointed end (the slow‐growing end) of an actin filament, was studied. An improved Escherichia coli expression system for chicken E‐tropomodulin was established and tropomodulin was prepared, Tmod (N39), in which 15 amino acid residues from the original C‐terminus are deleted at the DNA ...
Alla S Kostyukova +2 more
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Journal of Biological Chemistry, 2011 Tropomodulin is a tropomyosin-dependent actin filament capping protein involved in the structural formation of thin filaments and in the regulation of their lengths through its localization at the pointed ends of actin filaments.
Andrey V Kajava +2 more
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Tropomodulins and tropomodulin/tropomyosin interactions
Cellular and Molecular Life Sciences, 2007The tropomodulins are a family of proteins that cap the slow-growing (pointed) end of actin filaments and require tropomyosin for optimal function. Tropomodulin is an elongated molecule with a molecular mass of about 40 kDa. The C-terminal half of tropomodulin contains one compact cooperatively melting domain, whereas the N-terminal half has no ...
Alla S Kostyukova
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Current Biology, 2021
Arit Ghosh and Velia Fowler introduce the structural features and functions of tropomodulins - actin-binding proteins that cap the slow-growing (pointed) ends of actin filaments.
Arit, Ghosh, Velia M, Fowler
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Arit Ghosh and Velia Fowler introduce the structural features and functions of tropomodulins - actin-binding proteins that cap the slow-growing (pointed) ends of actin filaments.
Arit, Ghosh, Velia M, Fowler
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Tropomodulin binds to filensin intermediate filaments [PDF]
FEBS Letters, 2003 Tropomodulin (Tmod) is an actin filament pointed end capping protein found in the membrane skeleton of lens fiber cells. We demonstrate that Tmod4 is able to bind the lens‐specific intermediate filament protein, filensin, in either co‐sedimentation or solid phase binding assays in a saturable fashion, but with low affinity and stoichiometry ...
Roy A Quinlan, Velia M Fowler
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Tropomyosin-binding properties modulate competition between tropomodulin isoforms
Archives of Biochemistry and Biophysics, 2016 The formation and fine-tuning of cytoskeleton in cells are governed by proteins that influence actin filament dynamics. Tropomodulin (Tmod) regulates the length of actin filaments by capping the pointed ends in a tropomyosin (TM)-dependent manner. Tmod1,
Mert Çolpan +2 more
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Biochemical and Biophysical Research Communications, 2007
Microarray analysis was carried out to identify novel downstream target genes regulated by non-canonical Wnt signaling. We found that Tmod1, known as an actin-capping protein, is up-regulated by Wnt5a, while gelsolin, known as an actin-severing protein, is down-regulated by Wnt5a.
Eek-Hoon Jho
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Microarray analysis was carried out to identify novel downstream target genes regulated by non-canonical Wnt signaling. We found that Tmod1, known as an actin-capping protein, is up-regulated by Wnt5a, while gelsolin, known as an actin-severing protein, is down-regulated by Wnt5a.
Eek-Hoon Jho
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Lens Tropomodulin: Developmental Expression during Differentiation
Experimental Eye Research, 1996Lens epithelial cells undergo a dramatic transformation during the process of differentiation into elongated fiber cells. The membrane-associated actin cytoskeleton is likely to play a critical role in the stabilization and maintenance of the highly elongated fiber cell shape.
Mark A Sussman, J W Mcavoy, Gary E Lyons
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Tropomodulins: life at the slow end
Trends in Cell Biology, 2003Dynamic exchange of actin monomers at filament ends is crucial for the functional architecture of many cytoskeletal-dependent processes. Recent evidence indicates that tropomodulins (Tmods), a conserved family of actin-capping proteins that bind to the pointed (slow-growing) end of actin filaments, regulate a variety of actin structures, including ...
Robert S, Fischer, Velia M, Fowler
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Neural tropomodulin: developmental expression and effect of seizure activity
Developmental Brain Research, 1994Tropomodulin is a 40.6 kDa tropomyosin-binding protein associated with actin filaments in muscle and the membrane cytoskeleton in erythrocytes. We have detected tropomodulin mRNA and protein in brains of rats by northern and western blot analyses.
Mark A Sussman +2 more
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