Results 171 to 180 of about 76,365 (337)

Tissue‐Specific Extraction and Structural Elucidation of Actin‐Tropomyosin‐Myosin Complexes from Human and Rodent

open access: yesAggregate, Volume 7, Issue 1, January 2026.
We developed a general tissue‐extraction strategy that directly purifies native F‐actin and actin–tropomyosin–myosin (ATM) complexes from human and rodent muscles for cryo‐EM. Near‐atomic structures, including an HCM R404Q mouse model, reveal how a disease myosin mutation remodels ATM assembly and alters myosin conformation at the actin interface ...
Danni Li   +15 more
wiley   +1 more source

Crosstalk Between Brain-Derived Neurotrophic Factor And N-Methyl-D-Aspartate Receptor Signaling In Neurons [PDF]

open access: yes, 2008
Glutamate is the major excitatory neurotransmitter in brain exerting prosurvival effect on neurons via N-methyl-D-aspartate receptor (NMDAR) signaling under physiological conditions.
Georgiev, Danko   +3 more
core  

Relaxation kinetics of biological dimer adsorption models

open access: yes, 2001
We discuss the relaxation kinetics of a one-dimensional dimer adsorption model as recently proposed for the binding of biological dimers like kinesin on microtubules.
  +11 more
core   +1 more source

CSF proteomic profiling with amyloid and tau pathology identifies distinctive sex‐specific alteration of multiple proteins involved in Alzheimer's disease

open access: yesAlzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION In Alzheimer's disease (AD), females have higher prevalence and faster progression, but sex‐specific molecular findings in AD are limited. METHODS We comprehensively examined 6162 proteins in cerebrospinal fluid (CSF) from 2496 participants to identify sex‐specific proteomic alteration by CSF amyloid beta (Aβ)42 and phosphorylated
Anh N. Do   +17 more
wiley   +1 more source

Complexes of smooth muscle tropomyosin with F‐actin studied by differential scanning calorimetry [PDF]

open access: bronze, 2000
Dmitrii I. Levitsky   +6 more
openalex   +1 more source

Lifestyle and Behavioural Intervention Therapy for Enhanced Hippocampal Neuroplasticity

open access: yesLifestyle Medicine, Volume 7, Issue 1, January 2026.
ABSTRACT Background The neurogenic and neuroplastic capability of the brain plays a crucial role in mitigating responses to internal and external environmental stimuli. However, this process is inhibited in obesity, neurodegenerative and psychological disorders, the prevalence of which has increased on a global scale.
Ebrahim Samodien   +4 more
wiley   +1 more source

Tropomyosin Isoforms Segregate into Distinct Clusters on Single Actin Filaments

open access: yesBiomolecules
Tropomyosins (Tpms) are rod-shaped proteins that interact head-to-tail to form a continuous polymer along both sides of most cellular actin filaments. Head-to-tail interaction between adjacent Tpm molecules and the formation of an overlap complex between
Peyman Obeidy   +4 more
doaj   +1 more source

Tropomyosin Isoforms Specify Functionally Distinct Actin Filament Populations In Vitro

open access: yesCurrent Biology, 2017
Gergana Gateva   +9 more
semanticscholar   +1 more source

An Integrated Engineering Approach to Creating Health‐Modulating Postbiotics

open access: yesMolecular Nutrition &Food Research, Volume 70, Issue 1, January 2026.
Postbiotics have emerged as a promising alternative to live probiotics, offering comparable health benefits while overcoming challenges related to safety, stability, and shelf life. The review addresses current challenges in standardizing postbiotic definitions and production processes, and by outlining future research directions necessary to unlock ...
Michael Leonidas Chikindas   +10 more
wiley   +1 more source

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