Modeling Human Cardiac Thin Filament Structures
Frontiers in Physiology, 2022 Striated muscle contraction is regulated in a calcium-dependent manner through dynamic motions of the tropomyosin/troponin polymer, a multicomponent complex wrapped around actin-containing thin filaments.
Michael J. Rynkiewicz +2 more
doaj +1 more source
The Effect of Tropomyosin Mutations on Actin-Tropomyosin Binding: In Search of Lost Time [PDF]
Biophysical Journal, 2019 The initial binding of tropomyosin onto actin filaments and then its polymerization into continuous cables on the filament surface must be precisely tuned to overall thin-filament structure, function, and performance. Low-affinity interaction of tropomyosin with actin has to be sufficiently strong to localize the tropomyosin on actin, yet not so tight ...
William Lehman +3 more
openaire +3 more sources
Comparative proteomic profiling reveals molecular characteristics associated with oogenesis and oocyte maturation during ovarian development of Bactrocera dorsalis (Hendel) [PDF]
, 2017 Time-dependent expression of proteins in ovary is important to understand oogenesis in insects. Here, we profiled the proteomes of developing ovaries from Bactrocera dorsalis (Hendel) to obtain information about ovarian development with particular ...
Wei, Dong +6 more
core +1 more source
Harnessing the therapeutic potential of bacterial extracellular vesicles via functional peptides
Interdisciplinary Medicine, EarlyView.Bacterial extracellular vesicles (BEVs) are increasingly exploited as therapeutic agents or delivery vehicles for disease treatment due to their intrinsic structure, delivery capacity, immunogenic property, facile production, and versatile modification.
Yejiao Shi +3 more
wiley +1 more source
Leiomodin creates a leaky cap at the pointed end of actin-thin filaments.
PLoS Biology, 2020 Improper lengths of actin-thin filaments are associated with altered contractile activity and lethal myopathies. Leiomodin, a member of the tropomodulin family of proteins, is critical in thin filament assembly and maintenance; however, its role is under
Dmitri Tolkatchev +7 more
doaj +1 more source
Amino Acid Changes at Arginine 204 of Troponin I Result in Increased Calcium Sensitivity of Force Development. [PDF]
, 2016 Mutations in human cardiac troponin I (cTnI) have been associated with restrictive, dilated, and hypertrophic cardiomyopathies. The most commonly occurring residue on cTnI associated with familial hypertrophic cardiomyopathy (FHC) is arginine (R), which ...
Cui, Ziyou +4 more
core +2 more sources
A comprehensive review on adaptive plasticity and recovery mechanisms post‐acquired brain injury
Neuroprotection, EarlyView.This figure illustrates the dynamic process of neurogenesis following brain injury, focusing on the roles of neural stem and progenitor cells at the injury site. Key mechanisms include axonal sprouting, synaptogenesis, dendritic remodeling, and brain‐derived neurotrophic factor signaling via TrkB receptors.
Ravi Kumar Rajan
wiley +1 more source
A Proteomic Study of Atherosclerotic Plaques in Men with Coronary Atherosclerosis
Diagnostics, 2019 Background: To study the changes in protein composition of atherosclerotic plaques at different stages of their development in coronary atherosclerosis using proteomics.
Ekaterina M. Stakhneva +9 more
doaj +1 more source
Comparative two-dimensional gel analysis and microsequencing identifies gelsolin as one of the most prominent downregulated markers of transformed human fibroblast and epithelial cells [PDF]
, 1990 A systematic comparison of the protein synthesis patterns of cultured normal and transformed human fibroblasts and epithelial cells, using two-dimensional gel protein analysis combined with computerized imaging and data acquisition, identified a 90-kD ...
Bauw, Guy +4 more
core +1 more source
Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction
PROTEOMICS, EarlyView.ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella +6 more
wiley +1 more source