Results 81 to 90 of about 59,695 (281)

Autoimmunity to Tropomyosin-Specific Peptides Induced by Mycobacterium leprae in Leprosy Patients: Identification of Mimicking Proteins

Frontiers in Immunology, 2018
BackgroundIt has been shown earlier that there is a rise in the levels of autoantibodies and T cell response to cytoskeletal proteins in leprosy. Our group recently demonstrated a rise in both T and B cell responses to keratin and myelin basic protein in
Itu Singh, Asha Ram Yadav, Keshar Kunja Mohanty, Kiran Katoch, Prashant Sharma, Vinay Kumar Pathak, Deepa Bisht, Umesh D. Gupta, Utpal Sengupta   +8 more
doaj   +1 more source

Localization of actin in Dictyostelium amebas by immunofluorescence [PDF]

, 1977
Antibody prepared against avian smooth muscle actin has been used to localize actin in the slime mold, Dictyostelium discoideum. The distribution of actin in migrating cells is different from that in feeding cells.
Eckert, Barry S., Lazarides, Elias
core   +2 more sources

A Novel Empirical Autoinduction Model to Characterize the Population Pharmacokinetics and Recommend Dose for Repotrectinib in Adult and Adolescents With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1‐3 Rearrangements

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Repotrectinib is approved in the US for treating ROS1‐positive non‐small cell lung cancer (NSCLC) and solid tumors harboring an NTRK gene fusion. A Population Pharmacokinetic (PopPK) model for repotrectinib was developed using data from 620 adults (118 healthy volunteers and 502 patients) across seven studies and 24 pediatric patients from one
Shengnan Du, Zheyi Hu, Jun Shen, Lora Hamuro, Justine Lam, Ming Lu, Li Zhu, Amit Roy, Anna Kondic   +8 more
wiley   +1 more source

Characterization of Contractile Proteins from Skeletal Muscle Using Gel-Based Top-Down Proteomics

Proteomes, 2019
The mass spectrometric analysis of skeletal muscle proteins has used both peptide-centric and protein-focused approaches. The term ‘top-down proteomics’ is often used in relation to studying purified proteoforms and their post-translational ...
Paul Dowling, Margit Zweyer, Dieter Swandulla, Kay Ohlendieck   +3 more
doaj   +1 more source

Dynamic Light Scattering from Semidilute Actin Solutions: A Study of Hydrodynamic Screening, Filament Bending Stiffness and the Effect of Tropomyosin/Troponin-Binding

, 1995
Quasi-elastic light scattering (QELS) is applied to investigate the effect of the tropomyosin/troponin complex (Tm/Tn) on the stiffness of actin filaments. The importance of hydrodynamic screening in semidilute solutions is demonstrated.
Baermann, M., Frey, E., Goetter, R., Kroy, K., Sackmann, E.   +4 more
core   +1 more source

A transcriptomic snapshot of early molecular communication between Pasteuria penetrans and Meloidogyne incognita [PDF]

, 2018
© The Author(s). 2018Background: Southern root-knot nematode Meloidogyne incognita (Kofoid and White, 1919), Chitwood, 1949 is a key pest of agricultural crops.
A Clark, AF Bird, AG Whitehead, AJ van Rossum, AN Nathoo, AR Hipkiss, AR Quinlan, B Boettner, B Ketterer, B Li, B Mannervik, B Raymond, C The, CA Perrett, CA Reinitz, CD Sifri, D Wong, DL McEwan, E Moreno-Arriola, E Peter, EE Penhoet, EL Pavlova, ES Kim, FA Partridge, FX Yu, G Simons, H Li, HR Nicholas, I Mohr, IK Vagelas, IR Cohen, Irene Bricchi, J Heino, J Papadopoulou, J Tang, J. P. Yan, JA Melo, JF Preston, K Hesp, K Kim, K. G. DAVIES, Keith G. Davies, KG Bankar, KG Davies, KG Davies, KG Davies, KG Davies, KH Nomura, KJ Livak, L Charles, L Lambrechts, L Lambrechts, LB Cohen, LE Waggoner, M Cohen, M Klass, MA Bakowski, MA Miller, ME Feder, MG Grabherr, MJ Gravato-Nobre, MR Calgaro, MS Gami, MS Kwa, N Borghi, N Kogata, N Lane, N Schormann, N Tavernarakis, N Tavernarakis, N Vibanco-P’erez, O Silva-García, P Abad, P. B. Szecsi, PE Kuwabara, PE Urwin, PK Papolu, PM Brophy, PM Brophy, PM Guimaraes, R Erion, R Roberts, RK Patel, RM Sayre, Rohit N. Shukla, S Anders, S Choi, S Das, S Echevarria-Zomeno, S Mahajan-Miklos, SC Johnson, SC Zevian, SE Chang, SF Altschul, SHE Kaufmann, SJ McTaggart, SM Barribeau, TE Hewlett, TJ Krieger, TL Dunbar, TM Kubiak, TM Roberts, TM Shinnick, U Rao, Uma Rao, V Giguere, V Phani, V Phani, V Phani, Victor Phani, Victor Phani, Vishal S. Somvanshi, X Chen, X Zou, Y Gonskikh, Y Moriya, Y Spiegel, Y Yarden, Y Zhang   +118 more
core   +1 more source

Incorporating Multiple Imputation Into Tanezumab Dose–Response Modeling of WOMAC Pain CFB Across Six Randomized Placebo‐Controlled Phase 3 Trials

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Multiple imputation is increasingly being used to deal with missing data in clinical trials. It is a simulation approach leading to multiple analyses of a pre‐defined number of datasets. For a pre‐defined statistical model, this is relatively straightforward, but for model development as typically conducted in Pharmacometrics, it is unclear ...
Martin Boucher, Scott Marshall, Puneet Gaitonde   +2 more
wiley   +1 more source

In vivo Imaging of oskar mRNA transport reveals the mechanism of posterior localization [PDF]

, 2008
oskar mRNA localization to the posterior of the Drosophila oocyte defines where the abdomen and germ cells form in the embryo. Although this localization requires microtubules and the plus end-directed motor, kinesin, its mechanism is controversial and ...
Vitaly L. Zimyanin, Katsiaryna Belaya, Jacques Pecreaux, Michael J. Gilchrist, Alejandra Clark, Ilan Davis, Daniel St Johnston, Bashirullah, Beach, Bertrand, Boswell, Brendza, Brendza, Brendza, Bullock, Bullock, Cha, Cha, Chou, Clark, Clark, Clark, Dahlgaard, Ephrussi, Erdelyi, Forrest, Fusco, Glotzer, Hachet, Hachet, Huynh, Januschke, Jenny, Kanai, Kim-Ha, Kim-Ha, MacDougall, Macchi, Manseau, Markussen, Martin, McGrail, Micklem, Mische, Mohr, Munro, Newmark, Oleynikov, Palacios, Palacios, Pokrywka, Rook, Serano, Serbus, St Johnston, St Johnston, Theurkauf, van Eeden, Weil, Welte, Wilkie   +60 more
core   +2 more sources

Nucleic Acid‐Modified Nanoparticles for Cancer Therapeutic Applications

Small, EarlyView.
Nucleic acid‐modified nanoparticles act as functional hybrids for chemodynamic, photodynamic, photothermal, and gene therapy of cancer cells. These are exemplified with aptamer‐modified catalytic nanoparticles, photosensitizer‐oligonucleotide functionalized nanoparticles, drug‐loaded stimuli‐responsive nucleic acid‐caged nanoparticle carriers, and ...
Yunlong Qin, Xinghua Chen, Itamar Willner   +2 more
wiley   +1 more source

Nebulette knockout mice have normal cardiac function, but show Z-line widening and up-regulation of cardiac stress markers [PDF]

, 2015
Aims: Nebulette is a 109 kDa modular protein localized in the sarcomeric Z-line of the heart. In vitro studies have suggested a role of nebulette in stabilizing the thin filament, and missense mutations in the nebulette gene were recently shown to be ...
Bang, Marie-Louise, Carullo, Pierluigi, Chen, Ju, Dalton, Nancy D., Gu, Yusu, Li, Xiaodong, Liang, Xingqun, Mastrototaro, Giuseppina, Peterson, Kirk L., Piroddi, Nicoletta, Poggesi, Corrado, Sheikh, Farah, Tesi, Chiara   +12 more
core   +2 more sources