Results 81 to 90 of about 59,695 (281)
BackgroundIt has been shown earlier that there is a rise in the levels of autoantibodies and T cell response to cytoskeletal proteins in leprosy. Our group recently demonstrated a rise in both T and B cell responses to keratin and myelin basic protein in
Itu Singh+8 more
doaj +1 more source
Localization of actin in Dictyostelium amebas by immunofluorescence [PDF]
Antibody prepared against avian smooth muscle actin has been used to localize actin in the slime mold, Dictyostelium discoideum. The distribution of actin in migrating cells is different from that in feeding cells.
Eckert, Barry S., Lazarides, Elias
core +2 more sources
ABSTRACT Repotrectinib is approved in the US for treating ROS1‐positive non‐small cell lung cancer (NSCLC) and solid tumors harboring an NTRK gene fusion. A Population Pharmacokinetic (PopPK) model for repotrectinib was developed using data from 620 adults (118 healthy volunteers and 502 patients) across seven studies and 24 pediatric patients from one
Shengnan Du+8 more
wiley +1 more source
Characterization of Contractile Proteins from Skeletal Muscle Using Gel-Based Top-Down Proteomics
The mass spectrometric analysis of skeletal muscle proteins has used both peptide-centric and protein-focused approaches. The term ‘top-down proteomics’ is often used in relation to studying purified proteoforms and their post-translational ...
Paul Dowling+3 more
doaj +1 more source
Quasi-elastic light scattering (QELS) is applied to investigate the effect of the tropomyosin/troponin complex (Tm/Tn) on the stiffness of actin filaments. The importance of hydrodynamic screening in semidilute solutions is demonstrated.
Baermann, M.+4 more
core +1 more source
A transcriptomic snapshot of early molecular communication between Pasteuria penetrans and Meloidogyne incognita [PDF]
© The Author(s). 2018Background: Southern root-knot nematode Meloidogyne incognita (Kofoid and White, 1919), Chitwood, 1949 is a key pest of agricultural crops.
A Clark+118 more
core +1 more source
ABSTRACT Multiple imputation is increasingly being used to deal with missing data in clinical trials. It is a simulation approach leading to multiple analyses of a pre‐defined number of datasets. For a pre‐defined statistical model, this is relatively straightforward, but for model development as typically conducted in Pharmacometrics, it is unclear ...
Martin Boucher+2 more
wiley +1 more source
In vivo Imaging of oskar mRNA transport reveals the mechanism of posterior localization [PDF]
oskar mRNA localization to the posterior of the Drosophila oocyte defines where the abdomen and germ cells form in the embryo. Although this localization requires microtubules and the plus end-directed motor, kinesin, its mechanism is controversial and ...
Vitaly L. Zimyanin+60 more
core +2 more sources
Nucleic Acid‐Modified Nanoparticles for Cancer Therapeutic Applications
Nucleic acid‐modified nanoparticles act as functional hybrids for chemodynamic, photodynamic, photothermal, and gene therapy of cancer cells. These are exemplified with aptamer‐modified catalytic nanoparticles, photosensitizer‐oligonucleotide functionalized nanoparticles, drug‐loaded stimuli‐responsive nucleic acid‐caged nanoparticle carriers, and ...
Yunlong Qin+2 more
wiley +1 more source
Nebulette knockout mice have normal cardiac function, but show Z-line widening and up-regulation of cardiac stress markers [PDF]
Aims: Nebulette is a 109 kDa modular protein localized in the sarcomeric Z-line of the heart. In vitro studies have suggested a role of nebulette in stabilizing the thin filament, and missense mutations in the nebulette gene were recently shown to be ...
Bang, Marie-Louise+12 more
core +2 more sources