Results 151 to 160 of about 74,566 (254)

Selective type II TRK inhibitors overcome xDFG mutation mediated acquired resistance to the second-generation inhibitors selitrectinib and repotrectinib

Acta Pharmaceutica Sinica B
Neurotrophic receptor kinase (NTRK) fusions are actionable oncogenic drivers of multiple pediatric and adult solid tumors, and tropomyosin receptor kinase (TRK) has been considered as an attractive therapeutic target for “pan-cancer” harboring these ...
Shuang Xiang, Xiaoyun Lu
doaj   +1 more source

Integrated multi‐omics analysis reveals metabolic reprogramming as a key driver of angiotensin II‐induced vascular remodeling

VIEW, Volume 7, Issue 1, February 2026.
This study investigates the molecular alterations underlying angiotensin II (Ang II)‐induced vascular remodeling in cardiovascular diseases using a multi‐omics approach. Through data exploration and integrated multi‐omics analysis, our findings reveal that Ang II‐driven vascular injury in vascular smooth muscle cells is mediated by metabolic ...
Yiwei Hu, Dan Zhao, Lingyan Zhong, Jianxujie Zheng, Dongxue Zhang, Enhui Wu, Qian Shi, Liang Qiao, Ling Lin   +8 more
wiley   +1 more source

A behind-the-scenes role of BDNF in the survival and differentiation of spermatogonia

Asian Journal of Andrology
Mouse spermatogenesis entails the maintenance and self-renewal of spermatogonial stem cells (SSCs), which require a complex web-like signaling network transduced by various cytokines.
Shin-ichi Tomizawa, Kazushige Kuroha, Michio Ono, Kuniko Nakajima, Kazuyuki Ohbo   +4 more
doaj   +1 more source

Ks1, an epithelial cell-specific gene, responds to early signals of head formation in Hydra [PDF]

, 1994
As a molecular marker for head specification in Hydra, we have cloned an epithelial cell-specific gene which responds to early signals of head formation.
Bosch, Thomas C. G., David, Charles N., Salgado, Luis M., Weinziger, Ruth   +3 more
core  

Caveolin-1 Phosphorylation Is Essential for Axonal Growth of Human Neurons Derived From iPSCs. [PDF]

, 2019
Proper axonal growth and guidance is essential for neuron differentiation and development. Abnormal neuronal development due to genetic or epigenetic influences can contribute to neurological and mental disorders such as Down syndrome, Rett syndrome, and
Almenar-Queralt, Angels, DerMardirossian, Celine, Head, Brian P, Leem, Joseph, Patel, Hemal H, Patel, Piyush M, Roth, David M, Wang, Shanshan, Zhang, Zheng   +8 more
core   +1 more source

Neurotrophic Receptor Tyrosine Kinase 3 as a Prognostic Biomarker in Breast Cancer Using Bioinformatic Analysis

Medicina
Background and Objectives: Neurotrophic receptor tyrosine kinase 3 (NTRK3) is a member of the tropomyosin receptor kinase family of receptor tyrosine kinases, which play a crucial role in neural development.
Jeongmin Choi, Jongwan Kim, Yong Wook Jung, Jong Ho Park, Jae-Ho Lee   +4 more
doaj   +1 more source

Important Considerations for Real-World Analysis of Neurotrophic Tyrosine Receptor Kinase Fusion Cancer and Tropomyosin Receptor Kinase Inhibitors. [PDF]

JCO Precis Oncol, 2023
Brose MS, Hong DS, Drilon A.
europepmc   +1 more source

RGS14 (414)-mediated prevention of an episodic memory loss: a study of molecular mechanism [PDF]

, 2015
A large proportion of human populations suffer memory impairments either caused by normal aging or afflicted by diverse neurological and neurodegenerative diseases. Memory enhancers and other drugs tested so far against memory loss have failed to produce
Navarro Lobato, Irene
core   +1 more source

Efficacy and safety of intra-articular injection of tropomyosin receptor kinase A inhibitor in painful knee osteoarthritis: a randomized, double-blind and placebo-controlled study.

Osteoarthritis and Cartilage, 2019
E. Krupka, G-L Jiang, C. Jan
semanticscholar   +1 more source

Compounds originating from the edible mushroom Auricularia auricula-judae inhibit tropomyosin receptor kinase B activity. [PDF]

Heliyon, 2023
Shahar O, Pereman I, Khamisie H, Ezov N, Danay O, Khattib A, Schweitzer R, Khatib S, Mahajna J.   +8 more
europepmc   +1 more source