Results 161 to 170 of about 2,582,733 (281)

Binding of smoothelin-like 1 to tropomyosin and calmodulin is mutually exclusive and regulated by phosphorylation [PDF]

, 2017
BACKGROUND: The smoothelin-like 1 protein (SMTNL1) can associate with tropomyosin (Tpm) and calmodulin (CaM), two proteins essential to the smooth muscle contractile process.
A Jancso, A Ulke-Lemée, A Ulke-Lemée, A Ulke-Lemée, A Villarroel, AA Wooldridge, Annegret Ulke-Lemée, B Lontay, B Lontay, CL Wang, D Chin, David Hao Sun, F Hofmann, H Ishida, H Ishida, Hans J. Vogel, Hiroaki Ishida, I Fleming, JA MacDonald, JM Graff, JN Rao, Justin A. MacDonald, K Bodoor, M Naka, MA Borman, MA Borman, MA Geeves, PW Gunning, PW Gunning, R Liu, R Wong, SB Marston, SJ Winder, SR Rannels, SR Turner, TJ Lukas   +35 more
core   +2 more sources

Dual Targeting of CDK and Tropomyosin Receptor Kinase Families by the Oral Inhibitor PHA-848125, an Agent with Broad-Spectrum Antitumor Efficacy [PDF]

, 2010
Clara Albanese, Rachele Alzani, Nadia Amboldi, Nilla Avanzi, Dario Ballinari, Maria Gabriella Brasca, Claudio Festuccia, Francesco Fiorentini, Giuseppe Locatelli, Wilma Pastori, Veronica Patton, Fulvia Roletto, Francesco Colotta, Arturo Galvani, Antonella Isacchi, Jürgen Moll, Enrico Pesenti, Ciro Mercurio, Marina Ciomei   +18 more
openalex   +1 more source

Muscle‐Derived miR‐200a‐3p Through Light‐Intensity Exercise May Contribute to Improve Memory Dysfunction in Type 2 Diabetic Mice

The FASEB Journal, Volume 39, Issue 7, 15 April 2025.
The findings suggest that light‐intensity exercise restores gastrocnemius muscle‐derived exosomal miR‐200a‐3p levels, improving spatial memory and hippocampal Mct2 mRNA levels in ob/ob mice, a type 2 diabetes model. Additionally, miR‐200a‐3p mimic injections alleviated memory dysfunction and replicated exercise‐induced hippocampal RNA changes.
Takeru Shima, Hayate Onishi, Chiho Terashima   +2 more
wiley   +1 more source

NTRK-rearranged spindle cell tumor with SPECC1L-NTRK3 fusion in the thoracic spine: a case report

Journal of Cancer Research and Clinical Oncology
Neurotrophic Tyrosine Receptor Kinase (NTRK)-rearranged spindle cell tumors are a category of soft tissue tumors characterized by rearrangements of the NTRK gene family (NTRK1, NTRK2, and NTRK3), which leads to distinct molecular genetics, morphological,
Mi Zhou, Huaiyuan Xu, Jianxiong Niu, Qibing Yang, Anqi Wang, Hao Wu, Xiangqin Wang, Meng Yang, Jinxin Hu, Qinglian Tang, Jin Wang   +10 more
doaj   +1 more source

An Intracellular Domain Fragment of the p75 Neurotrophin Receptor (p75NTR) Enhances Tropomyosin Receptor Kinase A (TrkA) Receptor Function [PDF]

, 2013
Dusan Matusica, Sune Skeldal, Alex M. Sykes, Nickless Palstra, Aanchal Sharma, Elizabeth J. Coulson   +5 more
openalex   +1 more source

LIM Homeobox 8 (Lhx8) Is a Key Regulator of the Cholinergic Neuronal Function via a Tropomyosin Receptor Kinase A (TrkA)-mediated Positive Feedback Loop [PDF]

, 2013
Takeyasu Tomioka, Takuya Shimazaki, Toshihiko Yamauchi, Toru Oki, Makoto Ohgoh, Hideyuki Okano   +5 more
openalex   +1 more source

Novel therapeutic strategies for rare mutations in non-small cell lung cancer

Scientific Reports
Lung cancer is still the leading cause of cancer-related mortality. Over the past two decades, the management of non-small cell lung cancer (NSCLC) has undergone a significant revolution.
Qitao Gou, Qiheng Gou, Xiaochuan Gan, Yuxin Xie   +3 more
doaj   +1 more source

Response to: ‘Role of nerve growth factor (NGF) and tropomyosin receptor kinase A (TrkA) in the pathogenesis of osteoarthritis. Might NGF be the link interwinding obesity and OA?’ by Iannone et al [PDF]

, 2015
L.N. Nwosu, David A. Walsh
openalex   +1 more source

A behind-the-scenes role of BDNF in the survival and differentiation of spermatogonia

Asian Journal of Andrology
Mouse spermatogenesis entails the maintenance and self-renewal of spermatogonial stem cells (SSCs), which require a complex web-like signaling network transduced by various cytokines.
Shin-ichi Tomizawa, Kazushige Kuroha, Michio Ono, Kuniko Nakajima, Kazuyuki Ohbo   +4 more
doaj   +1 more source

Hey1- and p53-dependent TrkC proapoptotic activity controls neuroblastoma growth.

PLoS Biology, 2018
The neurotrophin-3 (NT-3) receptor tropomyosin receptor kinase C (TrkC/NTRK3) has been described as a dependence receptor and, as such, triggers apoptosis in the absence of its ligand NT-3.
Marie Ménard, Clélia Costechareyre, Gabriel Ichim, Jonathan Blachier, David Neves, Loraine Jarrosson-Wuilleme, Reinhard Depping, Jan Koster, Pierre Saintigny, Patrick Mehlen, Servane Tauszig-Delamasure   +10 more
doaj   +1 more source