Important Considerations for Real-World Analysis of Neurotrophic Tyrosine Receptor Kinase Fusion Cancer and Tropomyosin Receptor Kinase Inhibitors. [PDF]
JCO Precis Oncol, 2023 Brose MS, Hong DS, Drilon A.
europepmc +1 more source
Stochastic models of the binding kinetics of VEGF-A to VEGFR1 and VEGFR2 in endothelial cells [PDF]
arXiv, 2016 Vascular endothelial growth factor receptors (VEGFRs) are receptor tyrosine kinases (RTKs) that regulate proliferation, migration, angiogenesis and vascular permeability of endothelial cells. VEGFR1 and VEGFR2 bind vascular endothelial growth factors (VEGFs), inducing receptor dimerisation and activation, characterised by phosphorylation of tyrosine ...
arxiv
ErbB4 tyrosine kinase inhibition impairs neuromuscular development in zebrafish embryos [PDF]
, 2020 Reseptorityrosiinikinaasit (RTK) ovat kasvutekijäreseptoreita, jotka välittävät solujen kasvua, erilaistumista ja selviytymistä. RTK:en yli-ilmentyminen ja mutaatiot ovatkin tavallista erilaisissa sairauksissa, kuten syövässä.
Mäenpää, Matias
core
Current Problems in Cancer: Case Reports, 2021 Objectives: Neurotrophic tropomyosin receptor kinase (NTRK) fusions might be an off-target resistance mechanism to ALK Tyrosine Kinase Inhibitors (TKIs) in the same way as it has been suggested with activating epidermal growth factor receptor (EGFR) TKIs.
Elena Corral de la Fuente +7 more
doaj
Salmonella chemoreceptors McpB and McpC mediate a repellent response to L-cystine: a potential mechanism to avoid oxidative conditions [PDF]
Lazova, M. D., Butler, M. T., Shimizu, T. S., and Harshey, R. M.,
Salmonella chemoreceptors McpB and McpC mediate a repellent response to
L-cystine: a potential mechanism to avoid oxidative conditions. Mol Microbiol
84 (4), 697 (2012), 2013 Chemoreceptors McpB and McpC in Salmonella enterica have been reported to promote chemotaxis in LB motility-plate assays. Of the chemicals tested as potential effectors of these receptors, the only response was towards L-cysteine and its oxidized form, L-cystine.
arxiv
The effects of melatonin on the descending pain inhibitory system and neural plasticity markers in breast cancer patients receiving chemotherapy : randomized, double-blinded, placebo-controlled trial [PDF]
, 2019 Background: Adjuvant chemotherapy for breast cancer (ACBC) has been associated with fatigue, pain, depressive symptoms, and disturbed sleep. And, previous studies in non-cancer patients showed that melatonin could improve the descending pain modulatory ...
Biazús, Jorge Villanova +9 more
core
Mitosis, Cytoskeleton Regulation, and Drug Resistance in Receptor Triple Negative Breast Cancer [PDF]
arXivDuring cell division, the receptor triple-negative MDA-MB-231 mitotic spindles are the largest in comparison to other BC cell lines. Many of the MDA-MB-231 spindles exhibit rapid lateral twisting during metaphase, which remains unaffected by knockdown of the oncogene Myc and treatment with inhibitors of the serine/threonine-protein kinase B-Raf and the
arxiv
Identification and characterization of an oncogenically modified actin associated protein [PDF]
, 1994 The actin cytoskeleton is crucial for a variety of cellular events such as cell locomotion, phagocytosis, cytokinesis and cell surface receptor movement. The control mechanisms for these actin based cellular events are provided by a large number of actin-
Shapland, Claire Elizabeth
core
Compounds originating from the edible mushroom Auricularia auricula-judae inhibit tropomyosin receptor kinase B activity. [PDF]
Heliyon, 2023 Shahar O +8 more
europepmc +1 more source
Molecular Targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) within the Zebrafish Ovary: Insights into TCDD-induced Endocrine Disruption and Reproductive Toxicity [PDF]
, 2008 TCDD is a reproductive toxicant and endocrine disruptor, yet the mechanisms by which it causes these reproductive alterations are not fully understood.
Carvan, Michael J., III +5 more
core +1 more source