Results 181 to 190 of about 2,582,733 (281)

Neurotrophic Receptor Tyrosine Kinase 3 as a Prognostic Biomarker in Breast Cancer Using Bioinformatic Analysis

Medicina
Background and Objectives: Neurotrophic receptor tyrosine kinase 3 (NTRK3) is a member of the tropomyosin receptor kinase family of receptor tyrosine kinases, which play a crucial role in neural development.
Jeongmin Choi, Jongwan Kim, Yong Wook Jung, Jong Ho Park, Jae-Ho Lee   +4 more
doaj   +1 more source

KinDEL: DNA-Encoded Library Dataset for Kinase Inhibitors [PDF]

arXiv
DNA-Encoded Libraries (DEL) are combinatorial small molecule libraries that offer an efficient way to characterize diverse chemical spaces. Selection experiments using DELs are pivotal to drug discovery efforts, enabling high-throughput screens for hit finding.
arxiv  

The Cyclin-Dependent Kinase Inhibitor and Tumor Suppressor Locus p16/INK4A- p14ARF and Regulation of the Transition Into and Out of the Cell Cycle [PDF]

, 2011
p16/INK4A/CDKN2A is an important tumor suppressor gene located in the INK4A/ARF locus, which encodes a 16 kDa protein known as p16, and a 14 kDa protein known as p14ARF in humans. p16 arrests cell cycle in early G1 phase thereby inhibiting the binding of
Agarwal, Payal
core  

Influenza A virus activates cellular Tropomyosin receptor kinase A (TrkA) signaling to promote viral replication and lung inflammation. [PDF]

PLoS Pathog, 2022
Verma V, Dileepan M, Huang Q, Phan T, Hu WS, Ly H, Liang Y.   +6 more
europepmc   +1 more source

Hidden in Plain Sight: Incidental Diagnosis of Metastatic Papillary Thyroid Microcarcinoma Without Radiologically Apparent Thyroid Tumor

AACE Clinical Case Reports
Background/Objective: Papillary thyroid cancer (PTC) is considered the most common form of thyroid cancer. Papillary thyroid microcarcinomas (PTMCs) are defined as papillary carcinomas that are
Natalie Rivera Vargas, MD, Moises Matos, MD, Mustafa Kinaan, MD, FACE   +2 more
doaj  

Tropomyosin receptor kinase B-mediated signaling in integration of neuropathic pain and obesity in diabetic polyneuropathy. [PDF]

Einstein (Sao Paulo), 2021
Filimonova T, Karakulova Y.
europepmc   +1 more source

Sensory Neuron-Specific Deletion of Tropomyosin Receptor Kinase A (TrkA) in Mice Abolishes Osteoarthritis (OA) Pain via NGF/TrkA Intervention of Peripheral Sensitization. [PDF]

Int J Mol Sci, 2022
O-Sullivan I, Kc R, Singh G, Das V, Ma K, Li X, Mwale F, Votta-Velis G, Bruce B, Natarajan Anbazhagan A, van Wijnen AJ, Im HJ.   +11 more
europepmc   +1 more source

High prevalence of NTRK fusions in sporadic dMMR/MSI mCRC RAS/RAF wild-type: an opportunity for a post-immune checkpoint inhibitors progression rescue strategy

ESMO Gastrointestinal Oncology
Background: Currently, mismatch repair deficient/microsatellite instable (dMMR/MSI) status constitutes a validated predictive marker of response to immune checkpoint inhibitors (ICIs) in patients with metastatic colorectal cancer (mCRC).
M. Svrcek, A. Cayre, T. Samaille, R. Colle, L. Mas, P. Bourgoin, E. Guillerm, R. Cohen, F. Penault-Llorca, T. André, N. Radosevic-Robin   +10 more
doaj  

Antibody-dependent cellular phagocytosis of tropomyosin receptor kinase C (TrkC) expressing cancer cells for targeted immunotherapy. [PDF]

Cancer Immunol Immunother, 2022
Lai PS, Usama SM, Kiew LV, Lee HB, Chung LY, Burgess K, Kue CS.   +6 more
europepmc   +1 more source

Japanese Society of Medical Oncology/Japan Society of Clinical Oncology/Japanese Society of Pediatric Hematology/Oncology-led clinical recommendations on the diagnosis and use of tropomyosin receptor kinase inhibitors in adult and pediatric patients with neurotrophic receptor tyrosine kinase fusion-positive advanced solid tumors. [PDF]

Int J Clin Oncol, 2023
Naito Y, Mishima S, Akagi K, Hayashi N, Hirasawa A, Hishiki T, Igarashi A, Ikeda M, Kadowaki S, Kajiyama H, Kato M, Kenmotsu H, Kodera Y, Komine K, Koyama T, Maeda O, Miyachi M, Nishihara H, Nishiyama H, Ohga S, Okamoto W, Oki E, Ono S, Sanada M, Sekine I, Takano T, Tao K, Terashima K, Tsuchihara K, Yatabe Y, Yoshino T, Baba E.   +31 more
europepmc   +1 more source