Results 71 to 80 of about 2,582,733 (281)

Development of small-molecule tropomyosin receptor kinase (TRK) inhibitors for NTRK fusion cancers

Acta Pharmaceutica Sinica B, 2021
Tropomyosin receptor kinase A, B and C (TRKA, TRKB and TRKC), which are well-known members of the cell surface receptor tyrosine kinase (RTK) family, are encoded by the neurotrophic receptor tyrosine kinase 1, 2 and 3 (NTRK1, NTRK2 and NTRK3) genes ...
Tingting Jiang, Guan Wang, Yao Liu, Lu Feng, Meng Wang, Jie Liu, Yi Chen, Liang Ouyang   +7 more
doaj  

Dominant role of GABAB2 and Gbetagamma for GABAB receptor-mediated-ERK1/2/CREB pathway in cerebellar neurons [PDF]

Cellular Signalling 19, 9 (2007) 1996-2002, 2008
gamma-aminobutyric acid type B (GABA(B)) receptor is an allosteric complex made of two subunits, GABA(B1) and GABA(B2). GABA(B2) plays a major role in the coupling to G protein whereas GABA(B1) binds GABA. It has been shown that GABA(B) receptor activates ERK(1/2) in neurons of the central nervous system, but the molecular mechanisms underlying this ...
arxiv   +1 more source

Selective inhibition of tropomyosin-receptor-kinase A (TrkA) reduces pain and joint damage in two rat models of inflammatory arthritis [PDF]

, 2016
Background: Inflammation is an essential component of arthritis pain. Nerve growth factor (NGF) plays a key role in acute and chronic pain states especially those associated with inflammation. NGF acts through tropomyosin-receptor-kinase A (TrkA).
A Bendele, A Bendele, AK Suokas, AM Bendele, B Nico, BG Petty, C Barthel, CD Dijkstra, CJ Woolf, CM Pearson, CS Bonnet, D Male, DA Walsh, DA Walsh, DA Walsh, DA Walsh, David A. Walsh, DL Shelton, DN Benslay, DR Sagar, G Schett, GR Lewin, HC Seegers, HG Schaible, Jed Pheneger, JR Ghilardi, JR Ghilardi, JR Ghilardi, Karyn S. Bouhana, KE McNamee, KM Mearow, KS Williams, L Aloe, L Aloe, L Djouhri, L Manni, LA Stoppiello, LN Nwosu, M Koltzenburg, NE Lane, NH Waseem, P Sanga, PI Mapp, PI Mapp, PI Mapp, PJ Tiseo, PP Sanna, S Ashraf, S Ashraf, S Ashraf, S Ashraf, S Ashraf, S Suri, Sadaf Ashraf, SB McMahon, Steven W. Andrews, TJ Coderre, WO Cooper   +57 more
core   +4 more sources

Genomic and proteomic profiling for cancer diagnosis in dogs [PDF]

, 2016
Global gene expression, whereby tumours are classified according to similar gene expression patterns or ‘signatures’ regardless of cell morphology or tissue characteristics, is being increasingly used in both the human and veterinary fields to assist in ...
Morris, Joanna S.
core   +1 more source

Integration of a Phosphatase Cascade with the MAP Kinase Pathway provides for a Novel Signal Processing Function [PDF]

J Biol Chem 285,(2), 2010, 2009
We mathematically modeled the receptor-activated MAP kinase signaling by incorporating the regulation through cellular phosphatases. Activation induced the alignment of a phosphatase cascade in parallel with the MAP kinase pathway. A novel regulatory motif was thus generated, providing for the combinatorial control of each MAPK intermediate.
arxiv   +1 more source

Lower Serum Tropomyosin Receptor Kinase B Levels in Patients with Schizophrenia

Biomedical Journal, 2013
Brain-derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrkB) have previously been found to be reduced in the prefrontal cortex of patients with schizophrenia. In this study, we tried to investigate the protein levels of BDNF and TrkB from peripheral blood in the veins of individuals with schizophrenia and health controls.From ...
Tiao-Lai Huang, Yi-Yung Hung
openaire   +4 more sources

Inhibition of Tropomyosin Receptor Kinase A Signaling Negatively Regulates Megakaryopoiesis and induces Thrombopoiesis [PDF]

Scientific Reports, 2019
AbstractNeurotrophin signaling modulates the differentiation and function of mature blood cells. The expression of neurotrophin receptors and ligands by hematopoietic and stromal cells of the bone marrow indicates that neurotrophins have the potential to regulate hematopoietic cell fate decisions.
Vir B. Singh, Meera V. Singh, Ayse Kizilyer, Sanjay B. Maggirwar, Sumanun Suwunnakorn, James Palis   +5 more
openaire   +2 more sources

SORLA-mediated trafficking of TrkB enhances the response of neurons to BDNF. [PDF]

PLoS ONE, 2013
Stimulation of neurons with brain-derived neurotrophic factor (BDNF) results in robust induction of SORLA, an intracellular sorting receptor of the VPS10P domain receptor gene family.
Michael Rohe, Daniela Hartl, Anja Nawarecki Fjorback, Joachim Klose, Thomas E Willnow   +4 more
doaj   +1 more source

Modulation of neurotrophic signaling pathways by polyphenols [PDF]

, 2015
Polyphenols are an important class of phytochemicals, and several lines of evidence have demonstrated their beneficial effects in the context of a number of pathologies including neurodegenerative disorders such as Alzheimer's and Parkinson's disease. In
Firuzi, Omidreza, Hosseini, Razieh, Moosavi, Fatemeh, Saso, Luciano   +3 more
core   +1 more source

Troponin T3 regulates nuclear localization of the calcium channel Cavβ1a subunit in skeletal muscle [PDF]

, 2015
The voltage-gated calcium channel (Cav) β1a subunit (Cavβ1a) plays an important role in excitation-contraction coupling (ECC), a process in the myoplasm that leads to muscle-force generation. Recently, we discovered that the Cavβ1a subunit travels to the
Delbono, Osvaldo, Hereñú, Claudia Beatriz, Jiang, Yang, Messi, Maria Laura, Pereyra, Andrea Soledad, Taylor, Jackson, Wang, Zhong Min, Zhang, Tan   +7 more
core   +2 more sources