Results 71 to 80 of about 74,566 (254)

Amyloid β Instigates Cardiac Neurotrophic Signaling Impairment, Driving Alzheimer's Associated Heart Disease

Advanced Science, EarlyView.
This research identified cardiac amyloid pathology, neurotrophic factor depletion, and reduced myocardial nerve function in a transgenic model of cerebral amyloidosis (Tg2576), Aβ‐challenged cardiomyocytes, and in human AD heart tissue. These findings carry significant diagnostic and therapeutic implications, emphasizing the role of neuro‐signaling ...
Andrea Elia, Rebecca Parodi‐Rullan, Rafael Vazquez‐Torres, Ashley Carey, Huaqing Zhao, Sabzali Javadov, Silvia Fossati   +6 more
wiley   +1 more source

BRET biosensor analysis of receptor tyrosine kinase functionality

Frontiers in Endocrinology, 2013
Bioluminescence resonance energy transfer (BRET) is an improved version of earlier resonance energy transfer technologies used for the analysis of biomolecular protein interaction.
Sana eSiddiqui, Wei-na eCong, Caitlin M Daimon, Bronwen eMartin, Stuart eMaudsley   +4 more
doaj   +1 more source

Tropomyosin Receptor Kinase B Expressed in Oligodendrocyte Lineage Cells Functions to Promote Myelin Following a Demyelinating Lesion [PDF]

ASN Neuro, 2020
The levels of brain-derived neurotrophic factor (BDNF) in the corpus callosum have previously been shown to have a critical impact on oligodendrocyte (OLG) lineage cells during cuprizone-elicited demyelination. In particular, BDNF+/- mice exhibit greater losses in myelin protein levels compared to wild-type mice after cuprizone.
Yangyang Huang, Yeri J. Song, Maria Isaac, Shir Miretzky, Ashish Patel, W. Geoffrey McAuliffe, Cheryl F. Dreyfus   +6 more
openaire   +3 more sources

Oral squamous cell carcinoma-released brain-derived neurotrophic factor contributes to oral cancer pain by peripheral tropomyosin receptor kinase B activation.

Pain, 2021
Oral cancer pain is debilitating and understanding mechanisms for it is critical to develop novel treatment strategies treatment strategies. Brain-derived neurotrophic factor (BDNF) signaling is elevated in oral tumor biopsies and is involved with tumor ...
M. Grayson, Dominic A. Arris, Ping Wu, Jaclyn Merlo, T. Ibrahim, Fang-Mei Chang, V. Valenzuela, Shilpa Ganatra, S. Ruparel   +8 more
semanticscholar   +1 more source

A critical reappraisal of the carotid sinus and carotid bulb: Distinguishing neurohistological function from vascular geometry

The Anatomical Record, EarlyView.
This review redefines the carotid bulb (CB) as a variable geometric dilation shaped by hemodynamics and the carotid sinus (CS) as a conserved neurohistological baroreceptor field. Distinguishing these entities clarifies a century of anatomical confusion and links geometry, neurohistology, and clinical interpretation within a unified framework ...
Răzvan Costin Tudose, Nicolae Radu, Mugurel Constantin Rusu   +2 more
wiley   +1 more source

Orthogonal in vivo and in vitro membrane engineering enables human-like lipid remodeling of bacterial magnetosomes for functional TrkA display

Applied and Environmental Microbiology
The magnetotactic bacterium Magnetospirillum magneticum produces biogenic magnetic nanoparticles called magnetosomes, each comprising a magnetite core surrounded by a lipid bilayer.
Ryoto Tomoe, Shunya Waki, Keita Morimoto, Takaho Ogaki, Tsuyoshi Tanaka, Tomoko Yoshino   +5 more
doaj   +1 more source

Crosstalk Between Brain-Derived Neurotrophic Factor And N-Methyl-D-Aspartate Receptor Signaling In Neurons [PDF]

, 2008
Glutamate is the major excitatory neurotransmitter in brain exerting prosurvival effect on neurons via N-methyl-D-aspartate receptor (NMDAR) signaling under physiological conditions.
Georgiev, Danko, Kambe, Yuki, Taniura, Hideo, Yoneda, Yukio   +3 more
core  

Mechanisms of exercise-induced improvements in the contractile apparatus of the mammalian myocardium [PDF]

, 2010
One of the main outcomes of aerobic endurance exercise training is the improved maximal oxygen uptake, and this is pivotal to the improved work capacity that follows the exercise training.
Adams, Adams, American College of Sports Medicine Position Stand, American Heart Association, Amundsen, Anderson, Anversa, Beisvag, Belardinelli, Bergmann, Bers, Beyer, Blair, Blair, Boluyt, Bossuyt, Bye, Care, de Waard, Del Monte, Diffee, Diffee, Diffee, Diffee, Eto, Fletcher, Frampton, Gledhill, Gomez, Gulati, Hambrecht, Hambrecht, Haram, Hasenfuss, Helgerud, Hunter, Iemitsu, Jensen, Jolliffe, Kavanagh, Kemi, Kemi, Kemi, Kemi, Kemi, Kemi, Kemi, Kemi, Kemi, Kodoma, Kong, Kuum, Lankford, Laughlin, Lee, Levine, Liang, Liu, Loennechen, McMullen, Moholdt, Mokelke, Mole, Moore, Musch, Myers, Myles, Nakao, Natali, O’Connor, O’Neill, Paffenbarger, Palmer, Pelliccia, Penpargkul, Pluim, Richardson, Richardson, Rognmo, Saltin, Schaible, Schjerve, Shephard, Stolen, Tanasescu, Tate, Tibbits, Tjonna, Venetucci, Wagner, Wilkins, Wisloff, Wisloff, Wisloff, Wisloff, Wisloff, Wisloff, Zhang, Zhang   +98 more
core   +1 more source

Tropomyosin Receptor Kinase Inhibitors for the Treatment of TRK Fusion Cancer

Clinical Cancer Research, 2021
Chromosomal rearrangements of NTRK1–3 resulting in gene fusions (NTRK gene fusions) have been clinically validated as oncogenic drivers in a wide range of human cancers. Typically, NTRK gene fusions involve both inter- and intrachromosomal fusions of the
T. Laetsch, D. Hong
semanticscholar   +1 more source

Potent and rapid activation of tropomyosin-receptor kinase A in endometrial stromal fibroblasts by seminal plasma† [PDF]

Biology of Reproduction, 2018
Seminal plasma (SP), the liquid fraction of semen, is not mandatory for conception, but clinical studies suggest that SP improves implantation rates. Prior in vitro studies examining the effects of SP on the endometrium, the site of implantation, surprisingly revealed that SP induces transcriptional profiles associated with neurogenesis.
Martin, Jeremy W, Chen, Joseph C, Neidleman, Jason, Tatsumi, Keiji, Hu, James, Giudice, Linda C, Greene, Warner C, Roan, Nadia R   +7 more
openaire   +4 more sources