Results 91 to 100 of about 301,613 (233)

Activation of brain‐derived neurotrophic factor signaling in the basal forebrain reverses acute sleep deprivation‐induced fear memory impairments

Brain and Behavior, 2020
Introduction The mechanisms underlying sleep deprivation‐induced memory impairments and relevant compensatory signaling pathways remain elusive. We tested the hypothesis that increased brain‐derived neurotrophic factor (BDNF) expression in the basal ...
Tao Ma, Hao Zhang, Zhi‐Peng Xu, Yan Lu, Qiang Fu, Wei Wang, Guan‐Hua Li, Ying‐Ying Wang, Yi‐Tian Yang, Wei‐Dong Mi   +9 more
doaj   +1 more source

Downregulation of TrkC Receptors Increases Dendritic Arborization of Purkinje Cells in the Developing Cerebellum of the Opossum, Monodelphis domestica

Frontiers in Neuroanatomy, 2020
In therian mammals, the cerebellum is one of the late developing structures in the brain. Specifically, the proliferation of cerebellar granule cells occurs after birth, and even in humans, the generation of these cells continues during the first year of
Beata Tepper, Katarzyna Bartkowska, Malgorzata Okrasa, Sonia Ngati, Magdalena Braszak, Krzysztof Turlejski, Ruzanna Djavadian   +6 more
doaj   +1 more source

Homologous Control of Protein Signaling Networks [PDF]

Journal of Theoretical Biology 279 (2011) 29-43, 2010
In a previous paper we introduced a method called augmented sparse reconstruction (ASR) that identifies links among nodes of ordinary differential equation networks, given a small set of observed trajectories with various initial conditions. The main purpose of that technique was to reconstruct intracellular protein signaling networks. In this paper we
arxiv   +1 more source

A Novel Empirical Autoinduction Model to Characterize the Population Pharmacokinetics and Recommend Dose for Repotrectinib in Adult and Adolescents With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1‐3 Rearrangements

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Repotrectinib is approved in the US for treating ROS1‐positive non‐small cell lung cancer (NSCLC) and solid tumors harboring an NTRK gene fusion. A Population Pharmacokinetic (PopPK) model for repotrectinib was developed using data from 620 adults (118 healthy volunteers and 502 patients) across seven studies and 24 pediatric patients from one
Shengnan Du, Zheyi Hu, Jun Shen, Lora Hamuro, Justine Lam, Ming Lu, Li Zhu, Amit Roy, Anna Kondic   +8 more
wiley   +1 more source

A Novel Bis-Coumarin Targets Multiple Tyrosine Kinases of Key Signaling Pathways in Melanoma and Inhibits Melanoma Cell Survival, Proliferation, and Migration [PDF]

arXiv, 2020
Melanoma is one of the most dangerous skin malignancies due to its high metastatic tendency and high mortality. Activation of key signaling pathways enforcing melanoma progression depends on phosphorylation of tyrosine kinases, and oxidative stress. We here investigated the effect of the new bis-coumarin derivative (3,5-DCPBC) on human melanoma cell ...
arxiv  

Astrocytic Hevin/SPARCL‐1 Regulates Cognitive Decline in Pathological and Normal Brain Aging

Aging Cell, EarlyView.
Hevin/Sparcl‐1 is a synaptogenic protein secreted by astrocytes. We used adeno‐associated virus (AAV) to increase its expression in hippocampal astrocytes of APP/PSEN1 mice, an animal model for Alzheimer's disease (AD). This procedure improved cognitive performance both in the AD model and in middle‐aged wild‐type animals.
Felipe Cabral‐Miranda, Ana Paula Bergamo Araujo, Danilo Bilches Medinas, Flávia Carvalho Alcantara Gomes   +3 more
wiley   +1 more source

A critical role of tropomyosins in TGF-beta regulation of the actin cytoskeleton and cell motility in epithelial cells [PDF]

, 2004
We have investigated transforming growth factor beta (TGF-beta)-mediated induction of actin stress fibers in normal and metastatic epithelial cells. We found that stress fiber formation requires de novo protein synthesis, p38Mapk and Smad signaling.
Bakin, A. V., Darbary, H., Daroqui, C., Helfman, D. M., Rinehart, C., Safina, A.   +5 more
core   +2 more sources

Innovative pharmacotherapy for hepatic metabolic and chronic inflammatory diseases in China

British Journal of Pharmacology, EarlyView.
Abstract Liver disease constitutes a significant global health concern, particularly in China where it has distinctive characteristics. China grapples with a staggering 300 million cases, predominantly due to hepatitis B and metabolic non‐alcoholic fatty liver disease. Additionally, hepatocellular carcinoma has become a prevalent which is a lethal type
Feng Zhang, Jiaming Ju, Hongtao Diao, Jinglun Song, Yu bian, Baofeng Yang   +5 more
wiley   +1 more source

Mechanical Force and Actin Dynamics during Cutaneous Squamous Cell Carcinoma (cSCC) Progression: Opportunities for Novel Treatment Modalities [PDF]

, 2019
Cutaneous squamous cell carcinoma (cSCC) accounts for 25% of cutaneous malignancies diagnosed in the Caucasian population. Surgical removal in combination with radio- and chemotherapy is an effective treatment; however, prognosis for patients suffering ...
Boyle, Sarah, Kopecki, Zlatko
core   +1 more source

Diagnosis and management of tropomyosin receptor kinase (TRK) fusion sarcomas : expert recommendations from the World Sarcoma Network [PDF]

, 2020
Sarcomas are a heterogeneous group of malignancies with mesenchymal lineage differentiation. The discovery of neurotrophic tyrosine receptor kinase (NTRK) gene fusions as tissue-agnostic oncogenic drivers has led to new personalized therapies for a ...
Antonescu, C. R., Bjerkehagen, B., Blay, J-Y, Bovee, J. V. M. G., Boye, K., Chacon, M., Dei Tos, A. P., Demetri, G. D., Desai, J., Fletcher, J. A., Gelderblom, H., George, S., Gronchi, A., Haas, R. L., Hall, K. Sundby, Hindi, N., Hohenberger, P., Joensuu, H., Jones, R. L., Judson, Ian, Kang, Y-K, Kawai, A., Lazar, A. J., Le Cesne, A., Maestro, R., Maki, Rg, Martin, J., Naito, Y., Patel, S., Penault-Llorca, F., Raut, C. Premanand, Rutkowski, P., Safwat, A., Sbaraglia, M., Schaefer, I-M, Schoffski, P., Serrano, C., Shen, L., Stacchiotti, S., Tap, W. D., Thomas, D. M., Trent, J., Valverde, C., van der Graaf, W. T. A., von Mehren, M., Wagner, A., Wardelmann, E., Zalcberg, J.   +47 more
core   +4 more sources