Results 91 to 100 of about 107,195 (244)

Phenyl Saligenin Phosphate Induced Caspase-3 and c-Jun N-Terminal Kinase Activation in Cardiomyocyte-Like Cells [PDF]

, 2015
At present, little is known about the effect(s) of organophosphorous compounds (OPs) on cardiomyocytes. In this study we have investigated the effects of phenyl saligenin phosphate (PSP), two organophosphorothioate insecticides (diazinon and chlorpyrifos)
A. Christopher Garner, Alan J. Hargreaves, Chambers H., David J. Boocock, Fathi A. Smida, John M. Dickenson, Jortner B. S., Karki P., Lzyhnikov E. A., Shatha G. Felemban, Slavíková J., Winder C.   +11 more
core   +2 more sources

Psilocybin as a novel treatment for chronic pain

British Journal of Pharmacology, EarlyView.
Abstract Psychedelic drugs are under active consideration for clinical use and have generated significant interest for their potential as anti‐nociceptive treatments for chronic pain, and for addressing conditions like depression, frequently co‐morbid with pain.
Tate Askey, Reena Lasrado, Maria Maiarú, Gary J. Stephens   +3 more
wiley   +1 more source

The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain [PDF]

, 2016
The neurotrophin family of growth factors, comprised of nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT3), and neurotrophin 4 (NT4), is implicated in the physiology of chronic pain.
Angus Nedderman, Colin Robinson, David Brown, Gareth Waldron, Inaki Morao, James Bilsland, Karl R Gibson, Kimberly Skinner, Kiyoyuki Omoto, Mark Andrews, Paul Stupple, Peter J. Bungay, Russell Jones, Sarah E. Skerratt, Sharan K. Bagal, Susan Cole, Swarbrick M. E., Thomas Ryckmans   +17 more
core   +3 more sources

Regulation of Acetylcholine Quantal Release by Coupled Thrombin/BDNF Signaling in Mouse Motor Synapses

Cells, 2019
The aim of this study was to compare the acute effects of thrombin and brain-derived neurotrophic factor (BDNF) on spontaneous miniature endplate potentials (MEPPs) and multiquantal evoked endplate potentials (EPPs) in mouse neuromuscular junctions (NMJs)
Alexander Gaydukov, Polina Bogacheva, Ekaterina Tarasova, Anastasia Molchanova, Anna Miteva, Ekaterina Pravdivceva, Olga Balezina   +6 more
doaj   +1 more source

Synthetic microneurotrophins: Neurotrophin receptors for therapeutics of neurodegenerative diseases

British Journal of Pharmacology, EarlyView.
Neurodegenerative disorders are characterised by the chronic progressive degeneration of specific neuronal subtypes, neuroinflammation, myelin damage and synaptic loss. Despite their growing incidence, advancements in effective treatments remain limited, because of lack of knowledge for the aetiology of the diverse pathophysiology to design systematic ...
Ioanna Zota, Theodora Calogeropoulou, Konstantina Chanoumidou, Ioannis Charalampopoulos, Achille Gravanis   +4 more
wiley   +1 more source

Pericyte-mediated regulation of capillary diameter: a component of neurovascular coupling in health and disease [PDF]

, 2010
Because regional blood flow increases in association with the increased metabolic demand generated by localised increases in neural activity, functional imaging researchers often assume that changes in blood flow are an accurate read-out of changes in ...
Attwell, D., Hall, C.N., Hamilton, N.B.
core   +3 more sources

Brain-Derived Neurotrophic Factor (BDNF)-Induced Tropomyosin-Related Kinase B (Trk B) Signaling Is a Potential Therapeutic Target for Peritoneal Carcinomatosis Arising from Colorectal Cancer

PLoS ONE, 2014
Tropomyosin-related receptor kinase B (TrkB) signaling, stimulated by brain-derived neurotrophic factor (BDNF) ligand, promotes tumor progression, and is related to the poor prognosis of various malignancies.
Koji Tanaka, Y. Okugawa, Y. Toiyama, Y. Inoue, S. Saigusa, M. Kawamura, T. Araki, K. Uchida, Y. Mohri, M. Kusunoki   +9 more
semanticscholar   +1 more source

APE1 Attenuates ALK Tyrosine Kinase Inhibitors Sensitivity in NPM1‐ALK Positive Anaplastic Large Cell Lymphoma

Cancer Science, EarlyView.
The multifunctional DNA repair protein APE1 could activate NPM1‐ALK and reduce ALK‐TKI sensitivity through stabilization of NPM1‐ALK oligomer. APE1 low expression or mutation of the interaction point decreased tumor growth and increased TKI sensitivity in NPM1‐ALK+ ALCL.
Zheng Liu, Xinming Jing, Dong Li, Lingbo Bao, Yi Liu, Ruyi Hang, Xunjie Kuang, Ziqi Jiang, Xiaoyan Dai, Xueling Tong, Gianluca Tell, Mengxia Li   +11 more
wiley   +1 more source

Kidins220 and tumour development: Insights into a complexity of cross-talk among signalling pathways (Review) [PDF]

, 2017
The mechanistic complexes of kinase D-interacting substrate of 220 kDa/ankyrin repeat-rich membrane spanning (Kidins220/ARMS) bind and integrate a variety of cellular cues to mediate neuronal activities such as neuronal differentiation, survival, and ...
Cai, Jun, Cai, Shuo, Jiang, Wen Guo, Ye, Lin   +3 more
core   +1 more source

Involvement of BDNF/TrkB and ERK/CREB axes in nitroglycerin-induced rat migraine and effects of estrogen on these signals in the migraine

Biology Open, 2017
Migraine is a highly prevalent headache disorder, especially in women. Brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin receptor kinases (TrkB), as well as extracellular signal-regulated kinase (ERK) and its downstream target c-AMP ...
Jiu-Qing Guo, Hui-Hui Deng, Xiao Bo, Xiao-Su Yang   +3 more
doaj   +1 more source