Results 121 to 130 of about 301,613 (233)

Accuracy of position determination in Ca$^{2+}$ signaling [PDF]

, 2019
A living cell senses its environment and responds to external signals. In this work, we study theoretically, the precision at which cells can determine the position of a spatially localized transient extracellular signal. To this end, we focus on the case, where the stimulus is converted into the release of a small molecule that acts as a second ...
arxiv   +1 more source

Cathodal weak direct current decreases epileptic excitability with reduced neuronal activity and enhanced delta oscillations

The Journal of Physiology, EarlyView.
Abstract figure legend Polyspike epileptiform discharges and excitatory unit spike activities are observed in rats with kainic acid (KA)‐induced hippocampal seizures. A weak electric field generated by cathodal direct current stimulation (ctDCS) at CA1 reduces seizure excitability by decreasing the frequency and amplitude of epileptic spikes and ...
Chia‐Chu Chiang, Miao‐Er Chien, Yu‐Chieh Huang, Jyun‐Ting Lin, Sheng‐Fu Liang, Kuei‐Sen Hsu, Dominique M. Durand, Yi‐Jen Wu   +7 more
wiley   +1 more source

The link between sarcopenic obesity and Alzheimer's disease: a brain‐derived neurotrophic factor point of view

The Journal of Physiology, EarlyView.
Abstract figure legend A, Sarcopenic obesity is defined as the age‐related loss of skeletal muscle mass and function that often leads to the progression of comorbidities, such as Alzheimer's disease (AD). Though the exact link between the two diseases is unknown, alterations in brain‐derived neurotrophic factor (BDNF) may be a contributor.
Emily N. Copeland, Paul J. LeBlanc, Paula Duarte‐Guterman, Val A. Fajardo, Rebecca E. K. MacPherson   +4 more
wiley   +1 more source

Arterial–venous differences of brain‐derived neurotrophic factor isoforms across the brain and muscle after exercise at different intensities

The Journal of Physiology, EarlyView.
Abstract figure legend Exercise‐induced increases in forearm venous plasma and serum brain‐derived neurotrophic factor (BDNF) are often assumed to be indicative of release from the brain. Sixteen healthy and physically fit adults (20–40 years old) were recruited to investigate whether exercise‐induced changes in forearm venous mature BDNF (mBDNF) and ...
Olga Tarassova, Yiwen Jiang, Helena Wallin, Mats Jensen‐Urstad, Nikola Drca, Julia Röja, Marjan Pontén, Abram Katz, Jonna Nilsson, Maria M. Ekblom, Marcus Moberg   +10 more
wiley   +1 more source

Cellular mechanisms in sympatho‐modulation of the heart [PDF]

, 2017
Cardiovascular function relies on complex servo-controlled regulation mechanisms that involve both fast-acting feedback responses and long-lasting adaptations affecting the gene expression.
Schaub, M. C., Zaugg, M.
core  

Global proteomics analysis of the response to starvation in C. elegans [PDF]

, 2015
Periodic starvation of animals induces large shifts in metabolism but may also influence many other cellular systems and can lead to adaption to prolonged starvation conditions.
Alejandro Brenes Murillo, Angelo, Angus I. Lamond, Anton Gartner, Baugh, Bin Wang, Chang, Cox, Cui, Dong, Ehsan Pourkarimi, Felix, Fredens, Grun, Handke, Henderson, Hsin, Huang, Kaeberlein, Kenyon, Larance, Larance, Larance, Liang, Long, Ly, Mark Larance, McBryant, Murphy, Narbonne, Ong, Ooi, Pourkarimi, Raharjo, Rechavi, Ritorto, Robert Kent, Sabidó, Seidel, Sheaffer, Shen, Supek, Uno, Updike, Van Gilst, Van Gilst, Vellai, Wessel, Whittle, Yankovskaya, You, Yuan, Zhao   +52 more
core   +2 more sources

Metabolic Stability Assessment of Larotrectinib Using Liquid Chromatography Tandem Mass Spectrometry

Drug Design, Development and Therapy, 2020
Mohamed W Attwa, 1, 2 Adnan A Kadi, 1 Hany W Darwish 1, 3 1Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia; 2Students’ University Hospital, Mansoura University, Mansoura 35516, Egypt;
Attwa MW, Kadi AA, Darwish HW
doaj  

Increased hepatic PDGF-AA signaling mediates liver insulin resistance in obesity associated type 2 diabetes [PDF]

arXiv, 2017
Type 2 diabetes (T2D) is closely linked with non-alcoholic fatty liver disease (NAFLD) and hepatic insulin resistance, but the involved mechanisms are still elusive. Using DNA methylome and transcriptome analyses of livers from obese individuals, we found that both hypomethylation at a CpG site in PDGFA (encoding platelet derived growth factor alpha ...
arxiv  

Cardiac Troponin I Biosensors: Innovations in Real‐Time Diagnosis of Cardiovascular Diseases

Analytical Science Advances, Volume 6, Issue 1, June 2025.
ABSTRACT Cardiac troponin I (cTnI) is a crucial biological macromolecule found in the contractile apparatus of cardiac myocytes, exclusively expressed in cardiomyocytes. It is released into the bloodstream upon cardiac tissue injury, serving as a vital biomarker for the early detection of various heart diseases. Despite advancements in cTnI diagnostics
Sara Ebrahimi, Vahid Alivirdiloo, Mobasher Hajiabbasi, Shahab Masoumi, Mahya Mohammadi, Somayye Hosseini, Sogand Omidi Gargari, Ahmad Mobed   +7 more
wiley   +1 more source

Diet transition to a high-fat diet for 3 weeks reduces brain omega-3-fatty acid levels, alters BDNF signaling and induces anxiety & depression-like behavior in adult rats [PDF]

, 2012
Background: The consumption of diets high in calories and low in nutrient value is becoming increasingly common in modern society, which can lead to metabolic disorders like diabetes and obesity, and potentially to psychiatric disorders.
Fernando Gomez-Pinilla, Sandeep Sharma, Yumei Zhuang   +2 more
core   +1 more source