Results 121 to 130 of about 107,195 (244)

Pharmacologically diverse antidepressants facilitate TRKB receptor activation by disrupting its interaction with the endocytic adaptor complex AP-2

Journal of Biological Chemistry, 2019
Several antidepressant drugs activate tropomyosin-related kinase B (TRKB) receptor, but it remains unclear whether these compounds employ a common mechanism for TRKB activation.
S. M. Fred, L. Laukkanen, Cecilia A. Brunello, L. Vesa, H. Göös, Iseline Cardon, R. Moliner, Tanja Maritzen, M. Varjosalo, P. Casarotto, E. Castrén   +10 more
semanticscholar   +1 more source

Discovery of Allosteric, Potent, Subtype Selective, and Peripherally Restricted TrkA Kinase Inhibitors.

Journal of Medicinal Chemistry, 2019
Tropomyosin receptor kinases (TrkA, TrkB, TrkC) are activated by hormones of the neurotrophin family: nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT3), and neurotrophin 4 (NT4).
S. Bagal, Kiyoyuki Omoto, D. Blakemore, P. Bungay, J. Bilsland, Philip J Clarke, M. Corbett, C. Cronin, Jingrong Jean Cui, R. Dias, Neil J Flanagan, S. Greasley, R. Grimley, Eric Johnson, D. Fengas, Linda Kitching, M. Kraus, Indrawan J. McAlpine, Asako Nagata, Gareth J Waldron, J. Warmus   +20 more
semanticscholar   +1 more source

Diet transition to a high-fat diet for 3 weeks reduces brain omega-3-fatty acid levels, alters BDNF signaling and induces anxiety & depression-like behavior in adult rats [PDF]

, 2012
Background: The consumption of diets high in calories and low in nutrient value is becoming increasingly common in modern society, which can lead to metabolic disorders like diabetes and obesity, and potentially to psychiatric disorders.
Fernando Gomez-Pinilla, Sandeep Sharma, Yumei Zhuang   +2 more
core   +1 more source

Metabolic Stability Assessment of Larotrectinib Using Liquid Chromatography Tandem Mass Spectrometry

Drug Design, Development and Therapy, 2020
Mohamed W Attwa, 1, 2 Adnan A Kadi, 1 Hany W Darwish 1, 3 1Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia; 2Students’ University Hospital, Mansoura University, Mansoura 35516, Egypt;
Attwa MW, Kadi AA, Darwish HW
doaj  

TrkB kinase activity maintains synaptic function and structural integrity at adult neuromuscular junctions.

Journal of applied physiology, 2014
Activation of the tropomyosin-related kinase receptor B (TrkB) by brain-derived neurotrophic factor acutely regulates synaptic transmission at adult neuromuscular junctions (NMJs).
C. Mantilla, J. Stowe, Dylan C Sieck, L. Ermilov, Sarah M Greising, Chao Zhang, K. Shokat, G. Sieck   +7 more
semanticscholar   +1 more source

Gill transcriptome response to changes in environmental calcium in the green spotted puffer fish [PDF]

, 2010
Background Calcium ion is tightly regulated in body fluids and for euryhaline fish, which are exposed to rapid changes in environmental [Ca2+], homeostasis is especially challenging. The gill is the main organ of active calcium uptake and therefore plays
Canario, Adelino V. M., Matsumura, H., Pinto, Patricia IS, Power, Deborah, Reinhardt, Richard, Terauchi, Ryohei, Thorne, Michael A. S.   +6 more
core   +5 more sources

Tyrosine kinase as therapeutic target of neurodegenerative disorders

Brain Disorders
Classes of hereditary and sporadic illnesses known as neurodegenerative diseases are linked to gradual nervous system malfunction and neuronal death. Protein kinases are an increasingly popular class of pharmacological targets for disorders affecting ...
Dipanjan Karati, Dileep Kumar
doaj  

Brain-Derived Neurotrophic Factor (BDNF) Enhances Osteogenesis and May Improve Bone Microarchitecture in an Ovariectomized Rat Model

Cells
Background: Brain-derived neurotrophic factor (BDNF) has gained attention as a therapeutic agent due to its potential biological activities, including osteogenesis.
Eugene J. Park, Van-Long Truong, Woo-Sik Jeong, Woo-Kie Min   +3 more
doaj   +1 more source

Discovery of pyrazolo-thieno[3,2-d]pyrimidinylamino-phenyl acetamides as type-II pan-tropomyosin receptor kinase (TRK) inhibitors: Design, synthesis, and biological evaluation.

European journal of medicinal chemistry, 2021
Wei Yan, Lingtian Zhang, Fengping Lv, Marialuisa Moccia, F. Carlomagno, C. Landry, M. Santoro, F. Gosselet, Brendan Frett, Hong‐yu Li   +9 more
semanticscholar   +1 more source

NGF and Its Receptors in the Regulation of Inflammatory Response

International Journal of Molecular Sciences, 2017
There is growing interest in the complex relationship between the nervous and immune systems and how its alteration can affect homeostasis and result in the development of inflammatory diseases.
G. Minnone, F. De Benedetti, L. Bracci-Laudiero   +2 more
semanticscholar   +1 more source