Results 131 to 140 of about 301,613 (233)

A Monte Carlo study of ligand-dependent integrin signal initiation [PDF]

arXiv, 2010
Integrins are allosteric cell adhesion receptors that control many important processes, including cell migration, proliferation, and apoptosis. Ligand binding activates integrins by stabilizing an integrin conformation with separated cytoplasmic tails, thus enabling the binding of proteins that mediate cytoplasmic signaling.
arxiv  

Early genetic screening and cardiac intervention in patients with cardiomyopathies in a multidisciplinary clinic

ESC Heart Failure, Volume 12, Issue 3, Page 1942-1955, June 2025.
Abstract Aims Patients with cardiomyopathies are a heterogeneous group of patients who experience high morbidity and mortality. Early cardiac assessment and intervention with access to genetic counselling in a multidisciplinary Cardiomyopathy Clinic may improve outcomes and prevent progression to advanced heart failure.
Chandu Sadasivan, Luke R. Gagnon, Deepan Hazra, Kaiming Wang, Erik Youngson, Jissy Thomas, Anita Y.M. Chan, D. Ian Paterson, Finlay A. McAlister, Tara Dzwiniel, Wayne Tymchak, Susan Christian, Gavin Y. Oudit   +12 more
wiley   +1 more source

Binding of smoothelin-like 1 to tropomyosin and calmodulin is mutually exclusive and regulated by phosphorylation [PDF]

, 2017
BACKGROUND: The smoothelin-like 1 protein (SMTNL1) can associate with tropomyosin (Tpm) and calmodulin (CaM), two proteins essential to the smooth muscle contractile process.
A Jancso, A Ulke-Lemée, A Ulke-Lemée, A Ulke-Lemée, A Villarroel, AA Wooldridge, Annegret Ulke-Lemée, B Lontay, B Lontay, CL Wang, D Chin, David Hao Sun, F Hofmann, H Ishida, H Ishida, Hans J. Vogel, Hiroaki Ishida, I Fleming, JA MacDonald, JM Graff, JN Rao, Justin A. MacDonald, K Bodoor, M Naka, MA Borman, MA Borman, MA Geeves, PW Gunning, PW Gunning, R Liu, R Wong, SB Marston, SJ Winder, SR Rannels, SR Turner, TJ Lukas   +35 more
core   +2 more sources

Tyrosine kinase as therapeutic target of neurodegenerative disorders

Brain Disorders
Classes of hereditary and sporadic illnesses known as neurodegenerative diseases are linked to gradual nervous system malfunction and neuronal death. Protein kinases are an increasingly popular class of pharmacological targets for disorders affecting ...
Dipanjan Karati, Dileep Kumar
doaj  

Brain-Derived Neurotrophic Factor (BDNF) Enhances Osteogenesis and May Improve Bone Microarchitecture in an Ovariectomized Rat Model

Cells
Background: Brain-derived neurotrophic factor (BDNF) has gained attention as a therapeutic agent due to its potential biological activities, including osteogenesis.
Eugene J. Park, Van-Long Truong, Woo-Sik Jeong, Woo-Kie Min   +3 more
doaj   +1 more source

Structure and dynamics of dynorphin peptide and its receptor [PDF]

arXiv, 2019
Dynorphin is a neuropeptide involved in pain, addiction and mood regulation. It exerts its activity by binding to the kappa opioid receptor (KOP) which belongs to the large family of G-protein coupled receptors. The dynorphin peptide was discovered in 1975, while its receptor was cloned in 1993.
arxiv  

Identification and Validation of Circadian Rhythm‐Related Genes Involved in Intervertebral Disc Degeneration and Analysis of Immune Cell Infiltration via Machine Learning

JOR SPINE, Volume 8, Issue 2, June 2025.
Within this manuscript, bioinformatics and experimental methods are used to explore the role of circadian rhythm and immunity in Intervertebral Disc Degeneration (IVDD). CCND1, FOXO1, FRMD8, NTRK2, PRRT1, and TFPI were successfully demonstrated to be hub rhythm‐related genes in the process of IVDD together with immunity.
Yongbo Zhang, Liuyang Chen, Sheng Yang, Rui Dai, Hua Sun, Liang Zhang   +5 more
wiley   +1 more source

Role of Glutamate Excitotoxicity in Glioblastoma Growth and Its Implications in Treatment

Cell Biology International, Volume 49, Issue 5, Page 421-434, May 2025.
ABSTRACT Glioblastoma is a highly malignant and invasive type of primary brain tumor that originates from astrocytes. Glutamate, a neurotransmitter in the brain plays a crucial role in excitotoxic cell death. Excessive glutamate triggers a pathological process known as glutamate excitotoxicity, leading to neuronal damage.
Colin Moriarty, Natasha Gupta, Debanjan Bhattacharya   +2 more
wiley   +1 more source

Neurotrophins are expressed in giant cell arteritis lesions and may contribute to vascular remodeling [PDF]

, 2014
International audienceIntroduction: Giant cell arteritis (GCA) is characterized by intimal hyperplasia leading to ischaemic manifestations that involve large vessels.
Alexis Régent, Anne-Laure Fauchais, Antoine Brézin, Claire Le-Jeunne, Elisabeth Vidal, Elsa Molina, François Labrousse, Jean-Louis Bourges, Kim Heang Ly, Luc Mouthon, Marie-Odile Jauberteau, Philippe Bertin, Philippe Sindou, Pierre-Yves Robert, Sofiane Saada, Véronique Witko-Sarsat   +15 more
core   +2 more sources

Lattice ultrasensitivity amplifies signals in E. coli without fine-tuning [PDF]

arXiv
The E. coli chemosensory lattice, consisting of receptors, kinases, and adaptor proteins, is an important test case for biochemical signal processing. Kinase output is characterized by precise adaptation to a wide range of background ligand levels and large gain in response to small relative changes in concentration.
arxiv