Results 141 to 150 of about 302,760 (242)

Universal Proteomic Signature After Exercise‐Induced Muscle Injury in Muscular Dystrophies

Annals of Clinical and Translational Neurology, Volume 12, Issue 5, Page 998-1011, May 2025.
ABSTRACT Objective Several neuromuscular disorders (NMDs) are characterized by progressive muscle damage and are marked by the elevation of circulating muscle proteins from activity‐related injury. Despite a diverse array of genetic drivers, many NMDs share similar patterns of exercise intolerance and higher concentrations of muscle injury proteins ...
Mads G. Stemmerik, Benjamin Barthel, Nanna R. Andersen, Sofie V. Skriver, Alan J. Russell, John Vissing   +5 more
wiley   +1 more source

Blocking the tropomyosin receptor kinase A (TrkA) receptor inhibits pain behaviour in two rat models of osteoarthritis [PDF]

, 2015
Objectives: Tropomyosin receptor kinase A (TrkA) mediates nociceptor sensitisation by nerve growth factor (NGF), but it is unknown whether selective TrkA inhibition will be an effective strategy for treating osteoarthritis (OA) pain.
Apfel, Ashraf, Ayral, Barouch, Barthel, Bove, Bullock, Burston, Christiansen, David A Walsh, Felson, Fischer, Gerwin, Ghilardi, Ghilardi, Guingamp, Hill, Hochberg, Ivanavicius, Iwakura, Kidd, Lane, Laslett, Lilian N Nwosu, Linker, Lu, Ma, Manni, Mapp, Mapp, Mapp, McMahon, McNamee, Nicol, Nilsson, Opar, Orita, Paul I Mapp, Sagar, Sagar, Sagar, Sanga, Schaible, Schnitzer, Suokas, Szebenyi, Tiseo, Torres, Unger, Victoria Chapman, Walsh, Watson, Štempelj   +52 more
core   +1 more source

Upregulation of NGF/TrkA-Related Proteins in Dorsal Root Ganglion of Paclitaxel-Induced Peripheral Neuropathy Animal Model

Journal of Pain Research
Yeeun Kim,1,2,* Min-A Je,1,2,* Myeongguk Jeong,1,2 Hyeokjin Kwon,1,2 Aelee Jang,3 Jungho Kim,1,2 Go-Eun Choi1,2 1Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan, Busan, 46252, Republic of Korea;
Kim Y, Je MA, Jeong M, Kwon H, Jang A, Kim J, Choi GE   +6 more
doaj  

Discrimination of Membrane Antigen Affinity by B cells Requires Dominance of Kinetic Proofreading over Serial Triggering [PDF]

arXiv, 2010
B cells receptor (BCR) signaling in response to membrane-bound antigen increases with antigen affinity, a process known as affinity discrimination. We use computational modeling to show that B cell affinity discrimination requires that kinetic proofreading predominate over serial engagement.
arxiv  

Vessel‐On‐A‐Chip Coupled Proteomics Reveal Pressure‐Overload‐Induced Vascular Remodeling

Advanced Science, Volume 12, Issue 19, May 22, 2025.
A vessel‐on‐a‐chip system is developed to replicate both physiological and pathological vessel cyclic stretches. Proteomic analysis reveals pressure‐overload‐induced vascular remodeling, including cellular response to mechanical cues, cellular oxidative stresses, ER stress, and ceramide biosynthesis activation in the vessel‐on‐a‐chip system, well ...
Yanjun Liu, Jianxujie Zheng, Lingyan Zhong, Zengyu Wang, Dan Zhao, Hong Lin, Xiaoxue Zhang, Ke Meng, Xiaoxia Yang, Dongxue Zhang, Ling Lin, Liang Qiao   +11 more
wiley   +1 more source

Antisense oligonucleotides directed against App and Rab5 normalized endosomal Rab activity and reversed DS‐AD‐linked degenerative phenotypes in the Dp16 mouse model of Down syndrome

Alzheimer's &Dementia, Volume 21, Issue 5, May 2025.
Abstract INTRODUCTION Down syndrome (DS) markedly raises the risk of Alzheimer's disease (DS‐AD). Our findings identified widespread dysregulation of the endolysosomal network (ELN) in DS and DS‐AD brains, driven by increased APP gene dose, hyperactivation of RAB5, and elevated levels of guanine nucleotide exchange factors (GEFs) for RABs 7 and 11 ...
Xu‐Qiao Chen, Xinxin Zuo, Ann Becker, Michael Mante, Jazmin B. Florio, Satish G. Jadhav, Ricardo Albay, Aaron Johnstone, Dmitry Karachentsev, Robert Rissman, Hien Zhao, Steven F. Dowdy, William C. Mobley   +12 more
wiley   +1 more source

Amelioration of Chronic Ethanol Administration‐Induced Learning and Memory Impairments by High‐Intensity Interval Training (HIIT) and Ritalin

Brain and Behavior, Volume 15, Issue 5, May 2025.
The current study investigated the impacts of 8‐week high‐intensity interval training (HIIT) and Ritalin, alone and in combination, on cognitive functions and hippocampal oxidative parameters following chronic ethanol consumption in male rats. Adult male rats were divided into eight groups and received one of the following treatments: ethanol 20% (ET) (
Sara Shirazpour, Farahnaz Taheri, Gholamreza Sepehri, Mahla Zangiabadizadeh, Mostafa Zangiabadi, Najmeh Sadat Hosseini, Sara Sheikhi, Azadeh Shahrokhi Raeini, Sara Sheibani Tezerji   +8 more
wiley   +1 more source

Multi‐Omics Analysis Reveals Disturbances of Purine Metabolism and Glutamate Metabolism in the Hippocampus of Lipopolysaccharide‐Induced Mouse Model of Depression

Brain and Behavior, Volume 15, Issue 5, May 2025.
The study focused on a mouse model of depression induced by lipopolysaccharides (LPS) and employed innovative multi‐omics approaches, including two‐dimensional gel electrophoresis (2‐DE) for proteomics, liquid chromatography–mass spectrometry (LC–MS) for metabolomics, and real‐time polymerase chain reaction (PCR) microarray technology to analyze the ...
Wen‐Wen Li, Rui Xiao, Xue‐Yi Chen, Jun‐Cai Pu, Jian‐Jun Chen, Hai‐Yang Wang, Lan‐Xiang Liu, Dan Li, Yang‐Dong Zhang, Wen‐Xia Li, Peng Xie   +10 more
wiley   +1 more source

Molecular Targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) within the Zebrafish Ovary: Insights into TCDD-induced Endocrine Disruption and Reproductive Toxicity [PDF]

, 2008
TCDD is a reproductive toxicant and endocrine disruptor, yet the mechanisms by which it causes these reproductive alterations are not fully understood.
Carvan, Michael J., III, Hessner, Martin J., Hutz, Reinhold J., King Heiden, Tisha C., Rise, Matthew L., Struble, Craig   +5 more
core   +1 more source

Role of Glutamate Excitotoxicity in Glioblastoma Growth and Its Implications in Treatment

Cell Biology International, Volume 49, Issue 5, Page 421-434, May 2025.
ABSTRACT Glioblastoma is a highly malignant and invasive type of primary brain tumor that originates from astrocytes. Glutamate, a neurotransmitter in the brain plays a crucial role in excitotoxic cell death. Excessive glutamate triggers a pathological process known as glutamate excitotoxicity, leading to neuronal damage.
Colin Moriarty, Natasha Gupta, Debanjan Bhattacharya   +2 more
wiley   +1 more source