Results 151 to 160 of about 302,760 (242)

On TRacK With Larotrectinib in a Neonate With a Giant Congenital ETV6::NTRK3 Fusion‐Positive Infantile Fibrosarcoma of the Head and Neck

Head &Neck, Volume 47, Issue 5, Page E50-E57, May 2025.
ABSTRACT Background Infantile fibrosarcoma (IFS) is a rare pediatric tumor of intermediate malignancy with high local aggressiveness that typically presents in young infants. Its occurrence in the head and neck region is rare. Complete non‐mutilating surgical resection is often not possible, requiring multimodal treatment.
Teresa M. Cardesa‐Salzmann, Monika Sparber‐Sauer, Peter Hingst, Andreas Erbersdobler, Bjoern Schneider, Maja Hühns, Andre Jakob, Friederike Terpe, Christian Spang, Dorothea Stalmann, Claudia Bierwirth, Christina Hauenstein, Stefanie Märzheuser, Manfred Ballmann, Carl Friedrich Classen   +14 more
wiley   +1 more source

Alzheimer's Disease and Frontotemporal Dementia: A Review of Pathophysiology and Therapeutic Approaches

Journal of Neuroscience Research, Volume 103, Issue 5, May 2025.
ABSTRACT Alzheimer's disease (AD) is a devastating form of dementia, with the number of affected individuals rising sharply. The main hallmarks of the disease include amyloid‐beta plaque deposits and neurofibrillary tangles consisting of hyperphosphorylated tau protein, besides other pathological features that contribute to the disease's complexity ...
Sally Kelliny, Xin‐Fu Zhou, Larisa Bobrovskaya   +2 more
wiley   +1 more source

Oral 7,8‐Dihydroxyflavone Protects Retinal Ganglion Cells by Modulating the Gut‐Retina Axis and Inhibiting Ferroptosis via the Indoleacrylic Acid‐AhR‐ALDH1A3‐FSP1 Pathway

CNS Neuroscience &Therapeutics, Volume 31, Issue 5, May 2025.
Oral 7,8‐Dihydroxyflavone (7,8‐DHF) protects retinal ganglion cells by modulating the gut‐retina axis, increasing indoleacrylic acid (IDA) levels, and inhibiting ferroptosis via the AhR‐ALDH1A3‐FSP1 pathway, offering a novel therapeutic strategy for retinal neuroprotection. ABSTRACT Objectives 7,8‐Dihydroxyflavone (7,8‐DHF) activates the TrkB receptor,
Yanping Zhou, Yifan Feng, Yingxi Zhao, Yu Wu, Min Li, Xi Yang, Xinyuan Wu, Xiangwu Chen   +7 more
wiley   +1 more source

Safety, Pharmacokinetics, and Pharmacodynamics of a 6‐h N,N‐Dimethyltryptamine (DMT) Infusion in Healthy Volunteers: A Randomized, Double‐Blind, Placebo‐Controlled Trial

Clinical and Translational Science, Volume 18, Issue 5, May 2025.
ABSTRACT The serotonergic psychedelic N,N‐dimethyltryptamine (DMT) presumably stimulates neuroplasticity in vitro and in vivo, by which it may exert neuroprotective effects during acute ischemic stroke. Since neuroplasticity has been implicated in the mechanism of action of rehabilitative therapy in stroke recovery, a pharmacological augmentation ...
Katelijne V. van der Heijden, Rob G. J. A. Zuiker, Marije E. Otto, Christopher S. Bryan, Nancy Stewart, Christopher Stillwell, Marieke L. De Kam, Marloes B. van Leuken, Joop M. A. van Gerven, Gabriel E. Jacobs   +9 more
wiley   +1 more source

A Computational Approach to Identify Novel Protein Targets Uncovers New Potential Mechanisms of Action of Mirtazapine S(+) and R(−) Enantiomers in Rett Syndrome

Journal of Neurochemistry, Volume 169, Issue 5, May 2025.
Computational pipeline to identify potential drug targets and pathways for Rett syndrome, by analyzing ligand‐bound pockets and predicted drug affinities. ABSTRACT Rett syndrome (RTT) is a progressive neurodevelopmental disorder that affects approximately 1:10000 newborn girls and is primarily caused by mutations in the X‐linked gene MECP2.
Ottavia Maria Roggero, Nicolò Gualandi, Viviana Ciraci, Vittoria Berutto, Emanuele Carosati, Enrico Tongiorgi   +5 more
wiley   +1 more source

Cathodal weak direct current decreases epileptic excitability with reduced neuronal activity and enhanced delta oscillations

The Journal of Physiology, Volume 603, Issue 9, Page 2763-2782, 1 May 2025.
Abstract figure legend Polyspike epileptiform discharges and excitatory unit spike activities are observed in rats with kainic acid (KA)‐induced hippocampal seizures. A weak electric field generated by cathodal direct current stimulation (ctDCS) at CA1 reduces seizure excitability by decreasing the frequency and amplitude of epileptic spikes and ...
Chia‐Chu Chiang, Miao‐Er Chien, Yu‐Chieh Huang, Jyun‐Ting Lin, Sheng‐Fu Liang, Kuei‐Sen Hsu, Dominique M. Durand, Yi‐Jen Wu   +7 more
wiley   +1 more source

Mitosis, Cytoskeleton Regulation, and Drug Resistance in Receptor Triple Negative Breast Cancer [PDF]

arXiv
During cell division, the receptor triple-negative MDA-MB-231 mitotic spindles are the largest in comparison to other BC cell lines. Many of the MDA-MB-231 spindles exhibit rapid lateral twisting during metaphase, which remains unaffected by knockdown of the oncogene Myc and treatment with inhibitors of the serine/threonine-protein kinase B-Raf and the
arxiv  

The effects of melatonin on the descending pain inhibitory system and neural plasticity markers in breast cancer patients receiving chemotherapy : randomized, double-blinded, placebo-controlled trial [PDF]

, 2019
Background: Adjuvant chemotherapy for breast cancer (ACBC) has been associated with fatigue, pain, depressive symptoms, and disturbed sleep. And, previous studies in non-cancer patients showed that melatonin could improve the descending pain modulatory ...
Biazús, Jorge Villanova, Caumo, Wolnei, Cavalheiro, José Antônio Crespo, Fregni, Felipe, Santos, Vinícius Souza dos, Schuh, Fernando, Souza, Ana Cláudia de, Souza, Andressa de, Torres, Iraci Lucena da Silva, Zucatto, Ângela Erguy   +9 more
core  

Identification and characterization of an oncogenically modified actin associated protein [PDF]

, 1994
The actin cytoskeleton is crucial for a variety of cellular events such as cell locomotion, phagocytosis, cytokinesis and cell surface receptor movement. The control mechanisms for these actin based cellular events are provided by a large number of actin-
Shapland, Claire Elizabeth
core  

Repeated cold stress, an animal model for fibromyalgia, elicits proprioceptor-induced chronic pain with microglial activation in mice

Journal of Neuroinflammation
Background Fibromyalgia is characterized by chronic pain, fatigue, and other somatic symptoms. We have recently revealed that proprioceptor hyperactivation induces chronic pain in a rat model of myalgic encephalomyelitis.
Koji Wakatsuki, Sumiko Kiryu-Seo, Masaya Yasui, Hiroki Yokota, Haruku Kida, Hiroyuki Konishi, Hiroshi Kiyama   +6 more
doaj   +1 more source