The interplay between microRNAs and the neurotrophin receptor tropomyosin-related kinase C controls proliferation of human neuroblastoma cells [PDF]
Proceedings of the National Academy of Sciences, 2007 MicroRNAs (miRNAs) are tiny noncoding RNAs whose function as modulators of gene expression is crucial for the proper control of cell growth and differentiation. Although the profile of miRNA expression has been defined for many different cellular systems, the elucidation of the regulatory networks in which they are involved is only just emerging.
Pietro Laneve +7 more
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c-Src Is Required for Tropomyosin Receptor Kinase C (TrkC)-induced Activation of the Phosphatidylinositol 3-Kinase (PI3K)-AKT Pathway [PDF]
Journal of Biological Chemistry, 2007 TrkC mediates many aspects of growth and development in the central nervous system. TrkC is expressed in a variety of non-neuronal tissues as well as human cancers. TrkC overexpression may drive tumorigenesis, invasion, and metastatic capability in cancer cells.
Wook Jin +5 more
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Examining the Effects of Neurotrophin 3 and Nerve Growth Factor on the Interaction of Tropomyosin Receptor Kinase A and C [PDF]
Biophysical Journal, 2017 Tropomyosin receptor kinases (Trks) are known to initiate signaling cascades in response to their ligands, the neurotrophins. Trks are involved in multiple important key events responsible for the development of the mammalian nervous system. They are known to control synaptic strength, plasticity, neuronal survival, proliferation, migration, axonal ...
Fozia Ahmed, Kalina Hristova
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Expression of neurotrophin 3 and its tropomyosin-related kinase receptor C in human preantral follicles [PDF]
Fertility and Sterility, 2011 To investigate the expression of neurotrophin 3 (NT3) and its receptor tropomyosin-related kinase C (TrkC) in human preantral follicles. Neurotrophins appear to play important roles in preantral follicles. Data on ovarian NT3 and its receptor TrkC are sparse in humans.Immunohistochemical, in situ hybridization, and reverse transcriptase polymerase ...
Galia Oron +7 more
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Correction to Discovery of Entrectinib: A New 3-Aminoindazole as a Potent Anaplastic Lymphoma Kinase (ALK), c-ros Oncogene 1 Kinase (ROS1), and Pan-Tropomyosin Receptor Kinases (Pan-TRKs) inhibitor [PDF]
Journal of Medicinal Chemistry, 2019 Maria Menichincheri +28 more
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Scientific Reports, 2021 Constructive remodeling of focal esophageal defects with biodegradable acellular grafts relies on the ability of host progenitor cell populations to repopulate implant regions and facilitate growth of de novo functional tissue.
Gokhan Gundogdu +10 more
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Pharmaceuticals, 2022 Neurotrophins are considered as an attractive target for the development of antidepressants with a novel mechanism of action. Previously, the dimeric dipeptide mimetics of individual loops of nerve growth factor, NGF (GK-6, loop 1; GK-2, loop 4) and ...
Armen G. Mezhlumyan +6 more
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Respirology Case Reports, 2021 Chromosomal rearrangements involving the c‐ros oncogene 1 (ROS1) are identified in approximately 1% of non‐small cell lung cancer (NSCLC) patients. Crizotinib is the first tyrosine kinase inhibitor (TKI) against ROS1‐rearranged NSCLC. G2032R, a secondary
Mai Tanimura +7 more
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Resolving the binding-kinase discrepancy in bacterial chemotaxis: A nonequilibrium allosteric model and the role of energy dissipation [PDF]
Proc. Natl. Acad. Sci. U.S.A. 120, e2303115120 (2023), 2023 The Escherichia coli chemotaxis signaling pathway has served as a model system for studying the adaptive sensing of environmental signals by large protein complexes. The chemoreceptors control the kinase activity of CheA in response to the extracellular ligand concentration and adapt across a wide concentration range by undergoing methylation and ...
arxiv +1 more source