Results 11 to 20 of about 31,127 (214)

c-Src Is Required for Tropomyosin Receptor Kinase C (TrkC)-induced Activation of the Phosphatidylinositol 3-Kinase (PI3K)-AKT Pathway [PDF]

Journal of Biological Chemistry, 2008
TrkC mediates many aspects of growth and development in the central nervous system. TrkC is expressed in a variety of non-neuronal tissues as well as human cancers. TrkC overexpression may drive tumorigenesis, invasion, and metastatic capability in cancer cells.
Wook, Jin, Chohee, Yun, Joon, Jeong, Yangho, Park, Hy-De, Lee, Seong-Jin, Kim   +5 more
openaire   +3 more sources

Molecular mechanisms of esophageal epithelial regeneration following repair of surgical defects with acellular silk fibroin grafts

Scientific Reports, 2021
Constructive remodeling of focal esophageal defects with biodegradable acellular grafts relies on the ability of host progenitor cell populations to repopulate implant regions and facilitate growth of de novo functional tissue.
Gokhan Gundogdu, Mehmet Tosun, Duncan Morhardt, Ali Hashemi Gheinani, Khalid Algarrahi, Xuehui Yang, Kyle Costa, Cinthia Galvez Alegria, Rosalyn M. Adam, Wei Yang, Joshua R. Mauney   +10 more
doaj   +1 more source

Antidepressant-like Effects of BDNF and NGF Individual Loop Dipeptide Mimetics Depend on the Signal Transmission Patterns Associated with Trk

Pharmaceuticals, 2022
Neurotrophins are considered as an attractive target for the development of antidepressants with a novel mechanism of action. Previously, the dimeric dipeptide mimetics of individual loops of nerve growth factor, NGF (GK-6, loop 1; GK-2, loop 4) and ...
Armen G. Mezhlumyan, Anna V. Tallerova, Polina Y. Povarnina, Aleksey V. Tarasiuk, Nellya M. Sazonova, Tatiana A. Gudasheva, Sergey B. Seredenin   +6 more
doaj   +1 more source

High-fat diet-associated cognitive decline: Is zinc finger protein 1 (ZPR1) the molecular connection?

Current Research in Physiology, 2021
Zinc finger protein 1 (ZPR1) is required for cellular replication and viability. Recently, ZPR1 variant rs964184 has been repeatedly linked to high plasma triglyceride levels, metabolic syndrome, type 2 diabetes mellitus (T2DM), and nonalcoholic fatty ...
Mythri Chittilla, Nuraly S. Akimbekov, Mohammed S. Razzaque   +2 more
doaj   +1 more source

Immune-Mediated Inflammation May Contribute to the Pathogenesis of Cardiovascular Disease in Mucopolysaccharidosis Type I. [PDF]

, 2016
BackgroundCardiovascular disease, a progressive manifestation of α-L-iduronidase deficiency or mucopolysaccharidosis type I, continues in patients both untreated and treated with hematopoietic stem cell transplantation or intravenous enzyme replacement ...
Dickson, Patricia I, Ellinwood, N Matthew, Esko, Jeffrey D, Gordts, Philip L, Khalid, Omar, Schwartz, Philip H, Vera, Moin U, Wang, Raymond Y   +7 more
core   +8 more sources

The interplay between microRNAs and the neurotrophin receptor tropomyosin-related kinase C controls proliferation of human neuroblastoma cells [PDF]

Proceedings of the National Academy of Sciences, 2007
MicroRNAs (miRNAs) are tiny noncoding RNAs whose function as modulators of gene expression is crucial for the proper control of cell growth and differentiation. Although the profile of miRNA expression has been defined for many different cellular systems, the elucidation of the regulatory networks in which they are involved is only just emerging.
Pietro Laneve, DI MARCOTULLIO, LUCIA, GIOIA, UBALDO, M. E. Fiori, FERRETTI, ELISABETTA, GULINO, Alberto, BOZZONI, Irene, E. Caffarelli   +7 more
openaire   +5 more sources

Entrectinib for ROS1‐rearranged non‐small cell lung cancer after crizotinib‐induced interstitial lung disease: A case report

Respirology Case Reports, 2021
Chromosomal rearrangements involving the c‐ros oncogene 1 (ROS1) are identified in approximately 1% of non‐small cell lung cancer (NSCLC) patients. Crizotinib is the first tyrosine kinase inhibitor (TKI) against ROS1‐rearranged NSCLC. G2032R, a secondary
Mai Tanimura, Nobutaka Kataoka, Yusuke Kunimatsu, Rei Tsutsumi, Izumi Sato, Takayuki Nakano, Keiko Tanimura, Takayuki Takeda   +7 more
doaj   +1 more source

ENT-A010, a Novel Steroid Derivative, Displays Neuroprotective Functions and Modulates Microglial Responses

Biomolecules, 2022
Tackling neurodegeneration and neuroinflammation is particularly challenging due to the complexity of central nervous system (CNS) disorders, as well as the limited drug accessibility to the brain.
Canelif Yilmaz, Thanasis Rogdakis, Alessia Latorrata, Evangelia Thanou, Eleftheria Karadima, Eleni Papadimitriou, Eleni Siapi, Ka Wan Li, Theodora Katsila, Theodora Calogeropoulou, Ioannis Charalampopoulos, Vasileia Ismini Alexaki   +11 more
doaj   +1 more source

An NT-3-releasing bioscaffold supports the formation of TrkC-modified neural stem cell-derived neural network tissue with efficacy in repairing spinal cord injury

Bioactive Materials, 2021
The mechanism underlying neurogenesis during embryonic spinal cord development involves a specific ligand/receptor interaction, which may be help guide neuroengineering to boost stem cell-based neural regeneration for the structural and functional repair
Ge Li, Bao Zhang, Jia-hui Sun, Li-yang Shi, Meng-yao Huang, Li-jun Huang, Zi-jing Lin, Qiong-yu Lin, Bi-qin Lai, Yuan-huan Ma, Bin Jiang, Ying Ding, Hong-bo Zhang, Miao-xin Li, Ping Zhu, Ya-qiong Wang, Xiang Zeng, Yuan-shan Zeng   +17 more
doaj   +1 more source

Examining the Effects of Neurotrophin 3 and Nerve Growth Factor on the Interaction of Tropomyosin Receptor Kinase A and C [PDF]

Biophysical Journal, 2017
Tropomyosin receptor kinases (Trks) are known to initiate signaling cascades in response to their ligands, the neurotrophins. Trks are involved in multiple important key events responsible for the development of the mammalian nervous system. They are known to control synaptic strength, plasticity, neuronal survival, proliferation, migration, axonal ...
Fozia Ahmed, Kalina Hristova
openaire   +1 more source