Results 201 to 210 of about 107,195 (244)

Auricular Vagal Nerve Stimulation Inhibited Central Nerve Growth Factor/Tropomyosin Receptor Kinase A/Phospholipase C-Gamma Signaling Pathway in Functional Dyspepsia Model Rats With Gastric Hypersensitivity

Neuromodulation: Technology at the Neural Interface, 2023
Functional dyspepsia (FD), which has a complicated pathophysiologic process, is a common functional gastrointestinal disease. Gastric hypersensitivity is the key pathophysiological factor in patients with FD with chronic visceral pain. Auricular vagal nerve stimulation (AVNS) has the therapeutic effect of reducing gastric hypersensitivity by regulating
Jingzhu Zhou, Huan Chen, Wanli Xu, Zhe Fu, Shuai Zhou, Weijian Zhu, Zhaohui Zhang   +6 more
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Manganese modifies Neurotrophin-3 (NT3) and its tropomyosin receptor kinase C (TrkC) in the cortex: Implications for manganese-induced neurotoxicity

Food and Chemical Toxicology, 2019
Manganese (Mn), an essential micronutrient, has the potential to induce apoptosis. The NT3/TrkC ligand/receptor pair known as part of the classic neurotrophic theory plays a critical role in neuronal survival. However, whether the NT3/TrkC-mediated signaling pathways are involved in Mn-induced apoptosis of cortical neurons remains unknown.
Yiping Yang, Fu Wei, Jian Wang, Rui Chen, Jie Zhang, Danni Li, Dong Gan, Xiaobo Yang, Yunfeng Zou   +8 more
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Towards tropomyosin-related kinase B (TrkB) receptor ligands for brain imaging with PET: radiosynthesis and evaluation of 2-(4-[(18)F]fluorophenyl)-7,8-dihydroxy-4H-chromen-4-one and 2-(4-([N-methyl-(11)C]-dimethylamino)phenyl)-7,8-dihydroxy-4H-chromen-4-one.

Bioorganic & Medicinal Chemistry, 2013
The interaction of tropomyosin-related kinase B (TrkB) with the cognate ligand brain-derived neurotrophic factor (BDNF) mediates fundamental pathways in the development of the nervous system. TrkB signaling alterations are linked to numerous neurodegenerative diseases and conditions.
V. Bernard-Gauthier, M. Boudjemeline, P. Rosa-Neto, A. Thiel, R. Schirrmacher   +4 more
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Lactobacillus brevis-Fermented Gamma-Aminobutyric Acid Ameliorates Depression- and Anxiety-Like Behaviors by Activating the Brain-Derived Neurotrophic Factor-Tropomyosin Receptor Kinase B Signaling Pathway in BALB/C Mice

Journal of Agricultural and Food Chemistry
This study investigated the effects of Lactobacillus brevis-fermented gamma-aminobutyric acid (LB-GABA) on depressive and anxiety-like behaviors with the underlying molecular mechanism in a chronic stress model of BALB/c mice. LB-GABA attenuates both neuronal cell death and the increase of monoamine oxidase activity induced by hydrogen peroxide ...
Hyeongyeong Kim, Hoon Kim, Hyung Joo Suh, Hyeon‐Son Choi   +3 more
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Identification of Pyrrole[3,4‐c]pyrazoles as Potent Tropomyosin Receptor Kinase A (TrkA) Inhibitors

Bulletin of the Korean Chemical Society, 2016
Hyeonjeong Choe, You Hwa Son, Byung Jin Byun, Sang Un Choi, Kwang‐Ho Lee   +4 more
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Efficacy and safety of larotrectinib in pediatric patients with tropomyosin receptor kinase (TRK) fusion-positive cancer: An expanded dataset.

Journal of Clinical Oncology, 2022
10030 Background: Neurotrophic tyrosine receptor kinase ( NTRK) gene fusions are oncogenic drivers in various tumor types across all ages. Larotrectinib is a first-in-class, central nervous system (CNS)-active, highly selective tropomyosin receptor ...
L. Mascarenhas, Cornelis M. van Tilburg, F. Doz, C. Zwaan, C. Albert, Claudia Blattman, B. Geoerger, S. DuBois, N. Federman, R. Nagasubramanian, A. Pappo, T. Watt, R. Norenberg, M. Fellous, Esther De La Cuesta, T. Laetsch, R. Xu   +16 more
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Tropomyosin receptor kinase inhibitors: an updated patent review for 2016–2019

Expert Opinion on Therapeutic Patents, 2020
Introduction: Tropomyosin receptor kinases (Trks) control processes in the fields of growth, survival, and differentiation of neuronal processes. They also play a crucial role in neurodegenerative diseases as well as different types of cancer.
Justin J Bailey, Carolin Jaworski, D. Tung, C. Wängler, B. Wängler, R. Schirrmacher   +5 more
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Identification of [18F]TRACK, a Fluorine-18-Labeled Tropomyosin Receptor Kinase (Trk) Inhibitor for PET Imaging.

Journal of Medicinal Chemistry, 2018
Changes in expression and dysfunctional signaling of TrkA/B/C receptors and oncogenic Trk fusion proteins are found in neurological diseases and cancers. Here, we describe the development of a first 18F-labeled optimized lead suitable for in vivo imaging
V. Bernard-Gauthier, Andrew V. Mossine, Anne Mahringer, Arturo Aliaga, Justin J Bailey, X. Shao, J. Stauff, Janna Arteaga, P. Sherman, Marilyn Grand'maison, Pierre-Luc Rochon, B. Wängler, C. Wängler, P. Bartenstein, A. Kostikov, D. Kaplan, G. Fricker, P. Rosa-Neto, P. Scott, R. Schirrmacher   +19 more
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Syntheses and evaluation of carbon-11- and fluorine-18-radiolabeled pan-tropomyosin receptor kinase (Trk) inhibitors: exploration of the 4-aza-2-oxindole scaffold as Trk PET imaging agents.

ACS Chemical Neuroscience, 2015
Tropomyosin receptor kinases (TrkA/B/C) are critically involved in the development of the nervous system, in neurological disorders as well as in multiple neoplasms of both neural and non-neural origins.
V. Bernard-Gauthier, Arturo Aliaga, A. Aliaga, M. Boudjemeline, R. Hopewell, A. Kostikov, P. Rosa-Neto, A. Thiel, R. Schirrmacher   +8 more
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A peptide encoded by upstream open reading frame of MYC binds to tropomyosin receptor kinase B and promotes glioblastoma growth in mice

Science Translational Medicine
MYC promotes tumor growth through multiple mechanisms. Here, we show that, in human glioblastomas, the variant MYC transcript encodes a 114–amino acid peptide, MYC pre-mRNA encoded protein (MPEP), from the upstream open reading frame (uORF) MPEP ...
Fanying Li, Kailin Yang, Xinya Gao, Maolei Zhang, Danling Gu, Xujia Wu, Chenfei Lu, Qiulian Wu, Deobrat Dixit, Ryan C. Gimple, Yongping You, S. Mack, Yu Shi, Tiebang Kang, S. Agnihotri, Michael D. Taylor, Jeremy N. Rich, Nu Zhang, Xiuxing Wang   +18 more
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