Results 21 to 30 of about 300,718 (204)

ENT-A010, a Novel Steroid Derivative, Displays Neuroprotective Functions and Modulates Microglial Responses

Biomolecules, 2022
Tackling neurodegeneration and neuroinflammation is particularly challenging due to the complexity of central nervous system (CNS) disorders, as well as the limited drug accessibility to the brain.
Canelif Yilmaz, Thanasis Rogdakis, Alessia Latorrata, Evangelia Thanou, Eleftheria Karadima, Eleni Papadimitriou, Eleni Siapi, Ka Wan Li, Theodora Katsila, Theodora Calogeropoulou, Ioannis Charalampopoulos, Vasileia Ismini Alexaki   +11 more
doaj   +1 more source

Distinct roles of PIK3CA in the enrichment and maintenance of cancer stem cells in head and neck squamous cell carcinoma

Molecular Oncology, 2020
Recurrence and metastasis are the major causes of mortality in head and neck squamous cell carcinoma (HNSCC). It is suggested that cancer stem cells (CSCs) play pivotal roles in recurrence and metastasis.
Xi Chen, Yu Cao, Wafik Sedhom, Ling Lu, Yanqiu Liu, Haibo Wang, Masako Oka, Sophia Bornstein, Sherif Said, John Song, Shi‐Long Lu   +10 more
doaj   +1 more source

Repression of the Glucocorticoid Receptor Aggravates Acute Ischemic Brain Injuries in Adult Mice. [PDF]

, 2018
Strokes are one of the leading causes of mortality and chronic morbidity in the world, yet with only limited successful interventions available at present.
Concepcion, Katherine R, Fu, Yingjie, Huang, Lei, Li, Yong, Ma, Qingyi, Song, Minwoo A, Xiao, Daliao, Zhang, Lubo, Zhang, Peng   +8 more
core   +2 more sources

Caldesmon regulates actin dynamics to influence cranial neural crest migration in Xenopus [PDF]

, 2011
Caldesmon (CaD) is an important actin modulator that associates with actin filaments to regulate cell morphology and motility. Although extensively studied in cultured cells, there is little functional information regarding the role of CaD in migrating ...
Bronner-Fraser, Marianne, Kee, Yun, Nie, Shuyi   +2 more
core   +2 more sources

Comparative proteomic profiling reveals molecular characteristics associated with oogenesis and oocyte maturation during ovarian development of Bactrocera dorsalis (Hendel) [PDF]

, 2017
Time-dependent expression of proteins in ovary is important to understand oogenesis in insects. Here, we profiled the proteomes of developing ovaries from Bactrocera dorsalis (Hendel) to obtain information about ovarian development with particular ...
Li, Ran, Liu, Yu-Wei, Smagghe, Guy, Wang, Jin-Jun, Wei, Dong, Zhang, Meng-Yi, Zhang, Zheng   +6 more
core   +2 more sources

BRET biosensor analysis of receptor tyrosine kinase functionality

Frontiers in Endocrinology, 2013
Bioluminescence resonance energy transfer (BRET) is an improved version of earlier resonance energy transfer technologies used for the analysis of biomolecular protein interaction.
Sana eSiddiqui, Wei-na eCong, Caitlin M Daimon, Bronwen eMartin, Stuart eMaudsley   +4 more
doaj   +1 more source

A transcriptomic snapshot of early molecular communication between Pasteuria penetrans and Meloidogyne incognita [PDF]

, 2018
© The Author(s). 2018Background: Southern root-knot nematode Meloidogyne incognita (Kofoid and White, 1919), Chitwood, 1949 is a key pest of agricultural crops.
A Clark, AF Bird, AG Whitehead, AJ van Rossum, AN Nathoo, AR Hipkiss, AR Quinlan, B Boettner, B Ketterer, B Li, B Mannervik, B Raymond, C The, CA Perrett, CA Reinitz, CD Sifri, D Wong, DL McEwan, E Moreno-Arriola, E Peter, EE Penhoet, EL Pavlova, ES Kim, FA Partridge, FX Yu, G Simons, H Li, HR Nicholas, I Mohr, IK Vagelas, IR Cohen, Irene Bricchi, J Heino, J Papadopoulou, J Tang, J. P. Yan, JA Melo, JF Preston, K Hesp, K Kim, K. G. DAVIES, Keith G. Davies, KG Bankar, KG Davies, KG Davies, KG Davies, KG Davies, KH Nomura, KJ Livak, L Charles, L Lambrechts, L Lambrechts, LB Cohen, LE Waggoner, M Cohen, M Klass, MA Bakowski, MA Miller, ME Feder, MG Grabherr, MJ Gravato-Nobre, MR Calgaro, MS Gami, MS Kwa, N Borghi, N Kogata, N Lane, N Schormann, N Tavernarakis, N Tavernarakis, N Vibanco-P’erez, O Silva-García, P Abad, P. B. Szecsi, PE Kuwabara, PE Urwin, PK Papolu, PM Brophy, PM Brophy, PM Guimaraes, R Erion, R Roberts, RK Patel, RM Sayre, Rohit N. Shukla, S Anders, S Choi, S Das, S Echevarria-Zomeno, S Mahajan-Miklos, SC Johnson, SC Zevian, SE Chang, SF Altschul, SHE Kaufmann, SJ McTaggart, SM Barribeau, TE Hewlett, TJ Krieger, TL Dunbar, TM Kubiak, TM Roberts, TM Shinnick, U Rao, Uma Rao, V Giguere, V Phani, V Phani, V Phani, Victor Phani, Victor Phani, Vishal S. Somvanshi, X Chen, X Zou, Y Gonskikh, Y Moriya, Y Spiegel, Y Yarden, Y Zhang   +118 more
core   +1 more source

NT3/TrkC Pathway Modulates the Expression of UCP-1 and Adipocyte Size in Human and Rodent Adipose Tissue

Frontiers in Endocrinology, 2021
Neurotrophin-3 (NT3), through activation of its tropomyosin-related kinase receptor C (TrkC), modulates neuronal survival and neural stem cell differentiation.
María Bové, María Bové, Fermi Monto, Fermi Monto, Paloma Guillem-Llobat, Paloma Guillem-Llobat, M Dolores Ivorra, M Dolores Ivorra, M Antonia Noguera, M Antonia Noguera, Andrea Zambrano, Andrea Zambrano, M Salome Sirerol-Piquer, M Salome Sirerol-Piquer, M Salome Sirerol-Piquer, Ana Cristina Requena, Mauricio García-Alonso, Teresa Tejerina, Teresa Tejerina, José T. Real, José T. Real, José T. Real, Isabel Fariñas, Isabel Fariñas, Isabel Fariñas, Pilar D’Ocon, Pilar D’Ocon   +26 more
doaj   +1 more source

JND4135, a New Type II TRK Inhibitor, Overcomes TRK xDFG and Other Mutation Resistance In Vitro and In Vivo

Molecules, 2022
The tropomyosin receptor kinases (TRKs) have been validated as effective targets in anticancer drug discovery. Two first-generation TRK inhibitors have been approved into market and displayed an encouraging therapeutic response in cancer patients ...
Jie Wang, Yang Zhou, Xia Tang, Xiuwen Yu, Yongjin Wang, Shingpan Chan, Xiaojuan Song, Zhengchao Tu, Zhimin Zhang, Xiaoyun Lu, Zhang Zhang, Ke Ding   +11 more
doaj   +1 more source

Non-Aβ-dependent factors associated with global cognitive and physical function in alzheimer's disease: a pilot multivariate analysis [PDF]

, 2019
Recent literature highlights the importance of identifying factors associated with mild cognitive impairment (MCI) and Alzheimer's Disease (AD).
Di Baldassarre, Angela, Fonte, Cristina, Galazzo, Ilaria Boscolo, Ghinassi, Barbara, Muti, Ettore, Naro, Fabio, Pedrinolla, Anna, Pizzini, Francesca Benedetta, Rende, Mario, Schena, Federico, Smania, Nicola, Stabile, Anna Maria, Tamburin, Stefano, Venneri, Mary Anna, Venturelli, Massimo   +14 more
core   +2 more sources