Results 41 to 50 of about 300,718 (204)

Investigating the role of uncoupling of troponin I phosphorylation from changes in myofibrillar Ca(2+)-sensitivity in the pathogenesis of cardiomyopathy. [PDF]

, 2014
Contraction in the mammalian heart is controlled by the intracellular Ca2+ concentration as it is in all striated muscle, but the heart has an additional signalling system that comes into play to increase heart rate and cardiac output during exercise or ...
Marston, SB, Messer, AE
core   +2 more sources

Hey1- and p53-dependent TrkC proapoptotic activity controls neuroblastoma growth.

PLoS Biology, 2018
The neurotrophin-3 (NT-3) receptor tropomyosin receptor kinase C (TrkC/NTRK3) has been described as a dependence receptor and, as such, triggers apoptosis in the absence of its ligand NT-3.
Marie Ménard, Clélia Costechareyre, Gabriel Ichim, Jonathan Blachier, David Neves, Loraine Jarrosson-Wuilleme, Reinhard Depping, Jan Koster, Pierre Saintigny, Patrick Mehlen, Servane Tauszig-Delamasure   +10 more
doaj   +1 more source

A genomic analysis and transcriptomic atlas of gene expression in Psoroptes ovis reveals feeding- and stage-specific patterns of allergen expression [PDF]

, 2019
Background: Psoroptic mange, caused by infestation with the ectoparasitic mite, Psoroptes ovis, is highly contagious, resulting in intense pruritus and represents a major welfare and economic concern for the livestock industry Worldwide.
Bartley, Kathryn, Burgess, Stewart TG, Down, Rachel E, Dunn, Jackie, Marr, Edward J, Nisbet, Alasdair J, Nunn, Francesca G, Prickett, Jessica C, Rombauts, Stephane, Van de Peer, Yves, Van Leeuwen, Thomas, Weaver, Robert J   +11 more
core   +2 more sources

Study of microRNAs-21/221 as potential breast cancer biomarkers in Egyptian women [PDF]

, 2016
microRNAs (miRNAs) play an important role in cancer prognosis. They are small molecules, approximately 17–25 nucleotides in length, and their high stability in human serum supports their use as novel diagnostic biomarkers of cancer and other pathological
El Masry, Maha Rafik, Mohareb, Fady R., Motawi, Tarek Mohamed Kamal, Sadik, Nermin Abdel Hamid, Shaker, Olfat Gamil   +4 more
core   +1 more source

Gene-Set Enrichment Analysis for Identifying Genes and Biological Activities Associated with Growth Traits in Dromedaries [PDF]

, 2022
Simple Summary This project aimed to find biological themes affecting growth in dromedaries. Candidate SNPs associated with growth were mapped to 22 genes, and 25 significant themes were identified related to growth.
Asadzadeh, Nader, Banabazi, Mohammad Hossein, Burger, Pamela Anna, Esmaeilkhanian, Saeid, Harofte, Javad Zare, Karimi, Omid, Naderi, Ali Shafei, Roudbari, Zahra, Sani, Morteza Bitaraf   +8 more
core   +1 more source

Radioligands for Tropomyosin Receptor Kinase (Trk) Positron Emission Tomography Imaging

Pharmaceuticals, 2019
The tropomyosin receptor kinases family (TrkA, TrkB, and TrkC) supports neuronal growth, survival, and differentiation during development, adult life, and aging.
Ralf Schirrmacher, Justin J. Bailey, Andrew V. Mossine, Peter J. H. Scott, Lena Kaiser, Peter Bartenstein, Simon Lindner, David R. Kaplan, Alexey Kostikov, Gert Fricker, Anne Mahringer, Pedro Rosa-Neto, Esther Schirrmacher, Carmen Wängler, Björn Wängler, Alexander Thiel, Jean-Paul Soucy, Vadim Bernard-Gauthier   +17 more
doaj   +1 more source

Selective inhibition of tropomyosin-receptor-kinase A (TrkA) reduces pain and joint damage in two rat models of inflammatory arthritis [PDF]

, 2016
Background: Inflammation is an essential component of arthritis pain. Nerve growth factor (NGF) plays a key role in acute and chronic pain states especially those associated with inflammation. NGF acts through tropomyosin-receptor-kinase A (TrkA).
A Bendele, A Bendele, AK Suokas, AM Bendele, B Nico, BG Petty, C Barthel, CD Dijkstra, CJ Woolf, CM Pearson, CS Bonnet, D Male, DA Walsh, DA Walsh, DA Walsh, DA Walsh, David A. Walsh, DL Shelton, DN Benslay, DR Sagar, G Schett, GR Lewin, HC Seegers, HG Schaible, Jed Pheneger, JR Ghilardi, JR Ghilardi, JR Ghilardi, Karyn S. Bouhana, KE McNamee, KM Mearow, KS Williams, L Aloe, L Aloe, L Djouhri, L Manni, LA Stoppiello, LN Nwosu, M Koltzenburg, NE Lane, NH Waseem, P Sanga, PI Mapp, PI Mapp, PI Mapp, PJ Tiseo, PP Sanna, S Ashraf, S Ashraf, S Ashraf, S Ashraf, S Ashraf, S Suri, Sadaf Ashraf, SB McMahon, Steven W. Andrews, TJ Coderre, WO Cooper   +57 more
core   +4 more sources

Genomic and proteomic profiling for cancer diagnosis in dogs [PDF]

, 2016
Global gene expression, whereby tumours are classified according to similar gene expression patterns or ‘signatures’ regardless of cell morphology or tissue characteristics, is being increasingly used in both the human and veterinary fields to assist in ...
Morris, Joanna S.
core   +1 more source

Algebraic study of receptor-ligand systems: a dose-response analysis [PDF]

arXiv, 2022
The study of a receptor-ligand system generally relies on the analysis of its dose-response (or concentration-effect) curve, which quantifies the relation between ligand concentration and the biological effect (or cellular response) induced when binding its specific cell surface receptor.
arxiv  

Pharmacophore-Aided Virtual Screening and Molecular Dynamics Simulation Identifies TrkB Agonists for Treatment of -Deficiency Disorders

Bioinformatics and Biology Insights, 2023
Therapeutic intervention in cyclin-dependent kinase-like 5 (CDKL5) deficiency disorders (CDDs) has remained a concern over the years. Recent advances into the mechanistic interplay of signalling pathways has revealed the role of deficient tropomyosin ...
Ibitayo Abigail Ademuwagun, Gbolahan Oladipupo Oduselu, Solomon Oladapo Rotimi, Ezekiel Adebiyi   +3 more
doaj   +1 more source