Results 61 to 70 of about 107,195 (244)

Anti-Tumor Activity of AZD4547 Against NTRK1 Fusion Positive Cancer Cells Through Inhibition of NTRKs

Frontiers in Oncology, 2021
Inhibitors of tropomyosin-related kinases (TRKs) display remarkable outcomes in the regression of cancers harboring the Neurotrophin Receptors Tyrosine Kinase (NTRK) fusion gene.
Hanna Cho, Hanna Cho, Namkyoung Kim, Namkyoung Kim, Takashi Murakami, Taebo Sim, Taebo Sim   +6 more
doaj   +1 more source

A tropomyosin-receptor kinase-fused gene mutation associates with vacuolar myopathy

Neurology: Genetics, 2018
A 44-year-old Caucasian man presented with a 7-year history of upper and lower limb muscle fasciculations and cramps, progressive asymmetric weakness, muscle atrophy, and length-dependent sensory loss.
N. Madigan, J. Tracy, W. Litchy, Z. Niu, Chunhua Chen, K. Ling, M. Milone   +6 more
semanticscholar   +1 more source

Neurotrophic Receptor Tyrosine Kinase 2 (NTRK2) Alterations in Low-Grade Gliomas: Report of a Novel Gene Fusion Partner in a Pilocytic Astrocytoma and Review of the Literature

Case Reports in Pathology, 2020
Pilocytic astrocytoma is a low-grade glial neoplasm of the central nervous system (CNS) that tends to occur in the pediatric population and less commonly presents in adults.
Siobhan S. Pattwell, E. Konnick, Yajuan J. Liu, Rebecca A Yoda, L. Sekhar, P. Cimino   +5 more
semanticscholar   +1 more source

Aligned Conductive Magnetic Nanofibers with Directional Magnetic Field Stimulation Promotes Peripheral Nerve Regeneration

Advanced Science, EarlyView.
Peripheral nerve injury necessitates alternatives to autografts. This study combines magnetic nanoparticles, oriented PCL fibers, and Ppy to create a conductive, magnetically active scaffold. In vitro and in vivo experiments demonstrated enhanced downstream pathways of calcium signaling, as revealed by transcriptome analysis.
Zheyuan Fan, Wei Yu, Xinggui Wen, Xiangdong Ding, Xiang Li   +4 more
wiley   +1 more source

Trophic and neurotrophic factors in human pituitary adenomas (Review) [PDF]

, 2017
The pituitary gland is an organ that functionally connects the hypothalamus with the peripheral organs. The pituitary gland is an important regulator of body homeostasis during development, stress, and other processes.
Agostinelli, Enzo, Altissimi, Giancarlo, Artico, Marco, Bardella, Lia, Giangaspero, Felice, Minni, Antonio, Parnigotto, Pier Paolo, Pastore, Francesco Saverio, Spoletini, Marialuisa, Taurone, Samanta, Tombolini, Mario, Wierzbicki, Venceslao   +11 more
core   +1 more source

An NT-3-releasing bioscaffold supports the formation of TrkC-modified neural stem cell-derived neural network tissue with efficacy in repairing spinal cord injury

Bioactive Materials, 2021
The mechanism underlying neurogenesis during embryonic spinal cord development involves a specific ligand/receptor interaction, which may be help guide neuroengineering to boost stem cell-based neural regeneration for the structural and functional repair
Ge Li, Bao Zhang, Jia-hui Sun, Li-yang Shi, Meng-yao Huang, Li-jun Huang, Zi-jing Lin, Qiong-yu Lin, Bi-qin Lai, Yuan-huan Ma, Bin Jiang, Ying Ding, Hong-bo Zhang, Miao-xin Li, Ping Zhu, Ya-qiong Wang, Xiang Zeng, Yuan-shan Zeng   +17 more
doaj  

Environmental enrichment reverses cerebellar impairments caused by prenatal exposure to a synthetic glucocorticoid

AIMS Neuroscience, 2022
During prenatal life, exposure to synthetic glucocorticoids (SGCs) can alter normal foetal development, resulting in disease later in life. Previously, we have shown alterations in the dendritic cytoarchitecture of Purkinje cells in adolescent rat ...
Martina Valencia , Odra Santander, Eloísa Torres, Natali Zamora, Fernanda Muñoz , Rodrigo Pascual   +5 more
doaj   +1 more source

Genomic Heterogeneity Underlies Mixed Response to Tropomyosin Receptor Kinase Inhibition in Recurrent Glioma.

JCO Precision Oncology, 2018
Glioblastoma is the most common malignant primary brain tumor in adults. Despite aggressive initial treatment, recurrence is inevitable and almost always fatal. Treatment options for recurrent disease are limited and do not substantially improve survival.
A. Schram, P. Jonsson, A. Drilon, T. Bale, J. Hechtman, R. Benayed, B. Hanusch, R. Young, C. Grommes, N. Ku, T. Kaley, D. Hyman, B. S. Taylor   +12 more
semanticscholar   +1 more source

Rapamycin Alleviates Heart Failure Caused by Mitochondrial Dysfunction and SERCA Hypoactivity in Syntaxin 12/13 Deficient Models

Advanced Science, EarlyView.
Rapamycin alleviates heart failure via TFEB and CaMKII pathways in Syntaxin 12/13 deficient models. Stx12 deficiency causes heart failure via impaired iron trafficking to mitochondria, reducing respiratory complexes and sarcoplasmic reticulum Ca2+‐ATPase (SERCA).
Run‐Zhou Yang, Fang Li, Jiao Liu, Shu‐Ang Li, Dan‐Hua Liu, Zhuanbin Wu, Pei‐Pei Liu, Wenju Liu, Bin Zhou, Cizhong Jiang, Haibing Zhang, Ying Yu, Jian‐Sheng Kang   +12 more
wiley   +1 more source

Muscle Contraction Regulates BDNF/TrkB Signaling to Modulate Synaptic Function through Presynaptic cPKCα and cPKCβI

Frontiers in Molecular Neuroscience, 2017
The neurotrophin brain-derived neurotrophic factor (BDNF) acts via tropomyosin-related kinase B receptor (TrkB) to regulate synapse maintenance and function in the neuromuscular system.
Erica Hurtado, Víctor Cilleros, Laura Nadal, Anna Simó, Teresa Obis, Neus Garcia, Manel M. Santafé, Marta Tomàs, Katherine Halievski, Cynthia L. Jordan, Maria A. Lanuza, Josep Tomàs   +11 more
doaj   +1 more source