Results 81 to 90 of about 107,195 (244)

A critical role of tropomyosins in TGF-beta regulation of the actin cytoskeleton and cell motility in epithelial cells [PDF]

, 2004
We have investigated transforming growth factor beta (TGF-beta)-mediated induction of actin stress fibers in normal and metastatic epithelial cells. We found that stress fiber formation requires de novo protein synthesis, p38Mapk and Smad signaling.
Bakin, A. V., Darbary, H., Daroqui, C., Helfman, D. M., Rinehart, C., Safina, A.   +5 more
core   +2 more sources

Dual Targeting of CDK and Tropomyosin Receptor Kinase Families by the Oral Inhibitor PHA-848125, an Agent with Broad-Spectrum Antitumor Efficacy

Molecular Cancer Therapeutics, 2010
Altered expression and activity of cyclin-dependent kinase (CDK) and tropomyosin receptor kinase (TRK) families are observed in a wide variety of tumors.
C. Albanese, R. Alzani, N. Amboldi, N. Avanzi, D. Ballinari, M. Brasca, C. Festuccia, F. Fiorentini, G. Locatelli, W. Pastori, V. Patton, F. Roletto, F. Colotta, A. Galvani, A. Isacchi, J. Moll, E. Pesenti, C. Mercurio, M. Ciomei   +18 more
semanticscholar   +1 more source

Incorporating Multiple Imputation Into Tanezumab Dose–Response Modeling of WOMAC Pain CFB Across Six Randomized Placebo‐Controlled Phase 3 Trials

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Multiple imputation is increasingly being used to deal with missing data in clinical trials. It is a simulation approach leading to multiple analyses of a pre‐defined number of datasets. For a pre‐defined statistical model, this is relatively straightforward, but for model development as typically conducted in Pharmacometrics, it is unclear ...
Martin Boucher, Scott Marshall, Puneet Gaitonde   +2 more
wiley   +1 more source

Crosstalk Between Brain-Derived Neurotrophic Factor And N-Methyl-D-Aspartate Receptor Signaling In Neurons [PDF]

, 2008
Glutamate is the major excitatory neurotransmitter in brain exerting prosurvival effect on neurons via N-methyl-D-aspartate receptor (NMDAR) signaling under physiological conditions.
Georgiev, Danko, Kambe, Yuki, Taniura, Hideo, Yoneda, Yukio   +3 more
core  

Activation of brain‐derived neurotrophic factor signaling in the basal forebrain reverses acute sleep deprivation‐induced fear memory impairments

Brain and Behavior, 2020
Introduction The mechanisms underlying sleep deprivation‐induced memory impairments and relevant compensatory signaling pathways remain elusive. We tested the hypothesis that increased brain‐derived neurotrophic factor (BDNF) expression in the basal ...
Tao Ma, Hao Zhang, Zhi‐Peng Xu, Yan Lu, Qiang Fu, Wei Wang, Guan‐Hua Li, Ying‐Ying Wang, Yi‐Tian Yang, Wei‐Dong Mi   +9 more
doaj   +1 more source

Downregulation of TrkC Receptors Increases Dendritic Arborization of Purkinje Cells in the Developing Cerebellum of the Opossum, Monodelphis domestica

Frontiers in Neuroanatomy, 2020
In therian mammals, the cerebellum is one of the late developing structures in the brain. Specifically, the proliferation of cerebellar granule cells occurs after birth, and even in humans, the generation of these cells continues during the first year of
Beata Tepper, Katarzyna Bartkowska, Malgorzata Okrasa, Sonia Ngati, Magdalena Braszak, Krzysztof Turlejski, Ruzanna Djavadian   +6 more
doaj   +1 more source

BubR1 Insufficiency Drives Transcriptomic Alterations and Pathology Associated With Cardiac Aging and Heart Failure

Aging Cell, EarlyView.
Transcriptomic and cellular analyses of BubR1 hypomorphic hearts reveal disruptions in key pathways and upregulation of markers linked to impaired cardiac structure and function. Comparative transcriptomic analysis shows that BubR1 insufficiency mirrors changes seen in aged and failing hearts. A key finding of this study is that BubR1 levels decline in
Renju Pun, Aliya L. Haas, Aradhana Thapa, Sylar R. Takafuji, Rexton M. Suzuki, Gabrielle F. Kay, Li Zheng, Michelle Waknitz, Michael H. Kim, Darren J. Baker, Jan M. van Deursen, Paul L. Sorgen, Rebekah L. Gundry, Brian J. North   +13 more
wiley   +1 more source

A kinase-deficient NTRK2 splice variant predominates in glioma and amplifies several oncogenic signaling pathways

Nature Communications, 2020
Independent scientific achievements have led to the discovery of aberrant splicing patterns in oncogenesis, while more recent advances have uncovered novel gene fusions involving neurotrophic tyrosine receptor kinases (NTRKs) in gliomas.
Siobhan S. Pattwell, Sonali Arora, P. Cimino, T. Ozawa, Frank Szulzewsky, Pia Hoellerbauer, Tobias Bonifert, B. Hoffstrom, N. Boiani, H. Bolouri, C. Correnti, Barbara Oldrini, J. Silber, M. Squatrito, Patrick J. Paddison, E. Holland   +15 more
semanticscholar   +1 more source

Infantile Fibrosarcoma With NTRK3–ETV6 Fusion Successfully Treated With the Tropomyosin‐Related Kinase Inhibitor LOXO‐101

Pediatric Blood & Cancer, 2016
Infantile fibrosarcoma (IFS) is a rare pediatric cancer typically presenting in the first 2 years of life. Surgical resection is usually curative and chemotherapy is active against gross residual disease.
R. Nagasubramanian, Julie Wei, Paul R Gordon, J. Rastatter, M. Cox, A. Pappo   +5 more
semanticscholar   +1 more source

Innovative pharmacotherapy for hepatic metabolic and chronic inflammatory diseases in China

British Journal of Pharmacology, EarlyView.
Abstract Liver disease constitutes a significant global health concern, particularly in China where it has distinctive characteristics. China grapples with a staggering 300 million cases, predominantly due to hepatitis B and metabolic non‐alcoholic fatty liver disease. Additionally, hepatocellular carcinoma has become a prevalent which is a lethal type
Feng Zhang, Jiaming Ju, Hongtao Diao, Jinglun Song, Yu bian, Baofeng Yang   +5 more
wiley   +1 more source