Results 91 to 100 of about 172,067 (306)

Multiple molecular forms of circulating cardiac troponin: Analytical and clinical significance

, 2008
Cardiac troponin T (cTnT) and I (cTnI) are highly specific and sensitive biomarkers of myocardial cell damage and are now accepted as the ‘gold standard’ diagnostic test for acute coronary syndrome and supersede the classical muscle enzyme biomarkers ...
Collinson, P.O., Gaze, D.C.
core   +1 more source

First‐in‐human, phase I, randomized, safety, pharmacokinetic, food‐effect and pharmacodynamic study of a tyrosine kinase 2/Janus kinase 1 inhibitor, SDC‐1801

British Journal of Clinical Pharmacology, EarlyView.
Aim The purpose of this study is to evaluate safety, tolerability, pharmacokinetics (PK), food‐effect (FE) and pharmacodynamics (PD) of an oral tyrosine kinase‐2 (TYK2)/Janus kinase‐1 (JAK1) inhibitor, SDC‐1801, in healthy adult participants. Methods This first‐in‐human study randomized 95 male and female participants.
Chris Brearley, Sam Francis, John Reader, Judi Proctor   +3 more
wiley   +1 more source

The usefulness of serum troponin levels to predict 1-year survival rates in infective endocarditis

International Journal of Infectious Diseases, 2015
Background and aim: Infective endocarditis (IE) is associated with increased mortality and morbidity. In this study, we aimed to evaluate the role of troponin levels in predicting long-term survival in patients with IE.
Esra Gucuk Ipek, Yesim Guray, Burak Acar, Habibe Kafes, Lale Dinc Asarcikli, Gizem Cabuk, Burcu Demirkan, Mevlut Serdar Kuyumcu, Umit Guray   +8 more
doaj   +1 more source

Clinical evaluation of the ACS:180 cardiac troponin I assay

, 2001
All patients admitted to the coronary care unit with suspected acute coronary syndromes were evaluated by serial electrocardiography and blood draws on admission and at 4 and 12h from admission. Diagnosis was based on conventional WHO criteria.
Collinson, P.O., Wiggins, N., Gaze, D.C.
core   +1 more source

Do consumers and healthcare professionals report the same adverse event differently? A paired analysis of duplicate vaccine safety reports in Norway

British Journal of Clinical Pharmacology, EarlyView.
Aim This study aimed to compare how Norwegian healthcare professionals (HCPs) and consumers reported the same adverse event (AE) following immunization with vaccines against COVID‐19 during the COVID‐19 pandemic. Specifically, we aimed to compare the extent to which HCPs and consumers reported information relevant for assessing the causal relationship ...
Tommy Emil Dzus, Johaina Sarrage, Hilde Samdal, François Montastruc, Elena Rocca   +4 more
wiley   +1 more source

Changes in the investigation and management of suspected myocardial infarction and injury during COVID-19: a multi-centre study using routinely collected healthcare data

Frontiers in Cardiovascular Medicine
ObjectiveThe COVID-19 pandemic was associated with a reduction in the incidence of myocardial infarction (MI) diagnosis, in part because patients were less likely to present to hospital.
Lara Chammas, Kevin Yuan, Stephanie Little, Stephanie Little, Gail Roadknight, Gail Roadknight, Kinga A. Varnai, Kinga A. Varnai, Shing Chan Chang, Shirley Sze, Jim Davies, Andrew Tsui, Hizni Salih, Hizni Salih, Ben Glampson, Dimitri Papadimitriou, Abdulrahim Mulla, Kerrie Woods, Kerrie Woods, Kerrie Woods, Kevin O’Gallagher, Anoop D. Shah, Bryan Williams, Folkert W. Asselbergs, Folkert W. Asselbergs, Folkert W. Asselbergs, Erik Mayer, Richard Lee, Christopher Herbert, Tom Johnson, Stuart Grant, Nick Curzen, Ajay M. Shah, Divaka Perera, Riyaz S. Patel, Keith M. Channon, Keith M. Channon, Keith M. Channon, Amit Kaura, Jamil Mayet, David W. Eyre, Iain Squire, Raj Kharbanda, Raj Kharbanda, Raj Kharbanda, Andrew Lewis, Andrew Lewis, Andrew Lewis, Rohan S. Wijesurendra, Rohan S. Wijesurendra, Rohan S. Wijesurendra, Rohan S. Wijesurendra   +51 more
doaj   +1 more source

Biomarkers in acute coronary syndromes and their role in diabetic patients [PDF]

, 2005
Diabetic patients with acute coronary syndromes are at high risk for cardiovascular complications but risk stratification in these patients remains challenging.
Heeschen, Christopher, Christopher Heeschen   +1 more
core   +1 more source

Use of Cardiac Troponin for the Diagnosis of Cardiac Pathology in Postmortem Samples Taken at Autopsy

, 2023
The diagnosis of acute cardiac pathology is a clinical challenge in both the living and in the postmortem setting. Cardiac troponin (cTn) T and cardiac troponin I released from the contractile apparatus of cardiomyocytes into the circulation can be ...
Gaze, D.C.
core   +1 more source

Machine Learning Models of Phase Contrast Images Predict Efficiency of Human Pluripotent Stem Cell Differentiation to Cardiomyocytes

Biotechnology and Bioengineering, EarlyView.
Human pluripotent stem cells were differentiated to cTnT+ cardiomyocytes and imaged throughout the process using phase contrast. We predicted differentiation efficiency (cTnT+ area) from phase contrast and compared model performance with a live‐cell cTnT‐GFP reporter.
Austin K. Feeney, Yaniv Ovadia, Aaron D. Simmons, Christian Elabd, Claire J. Peplinski, Frank Li, Sean P. Palecek   +6 more
wiley   +1 more source

Cardiac Injury After Acute Ischemic Stroke: Are Women at Increased Risk?

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Marysia S. Tweet, Alejandro A. Rabinstein, Allan S. Jaffe   +2 more
doaj   +1 more source