Results 101 to 110 of about 230,788 (365)

Effects of canagliflozin on cardiovascular biomarkers in older adults with type 2 diabetes [PDF]

, 2017
Background: Sodium glucose co-transporter 2 (SGLT2) inhibitors may reduce cardiovascular and heart failure risk in patients with type 2 diabetes mellitus (T2DM).
Butler, Javed, Davies, Michael J., Desai, Mehul, Januzzi, James L., Jarolim, Petr, Sattar, Naveed, Vijapurkar, Ujjwala   +6 more
core   +1 more source

HMGB2 Promotes Cardiomyocyte Proliferation and Heart Regeneration Through MTA2‐Driven Metabolic Reprogramming

Advanced Science, EarlyView.
In contrast to the adult mammalian heart, which lacks regenerative capacity, the neonatal heart retains a transient regenerative capacity. In this study, high mobility group box 2 (HMGB2) is identified as a crucial protein driving heart regeneration based on comprehensive analyses using quantitative proteomics with tandem mass tag (TMT) labelling, RNA ...
Liu‐Hua Zhou, Ling‐Feng Gu, Yi‐Xi Chen, Peng Jing, Tong‐Tong Yang, Ye He, Yu‐Lin Bao, Xiang‐Zheng Zhang, Chong Du, Si‐Bo Wang, Tian‐Kai Shan, Jia‐Yi Chen, Hao Wang, Qi‐Ming Wang, Li‐Ping Xie, Yang Zhao, Yong Ji, Lian‐Sheng Wang   +17 more
wiley   +1 more source

Computational Studies of Cardiac and Skeletal Troponin

Frontiers in Molecular Biosciences, 2019
Troponin is a key regulatory protein in muscle contraction, consisting of three subunits troponin C (TnC), troponin I (TnI), and troponin T (TnT). Calcium association to TnC initiates contraction by causing a series of dynamic and conformational changes ...
Jacob D. Bowman, Steffen Lindert
doaj   +1 more source

Muscle Organoids Reveal Exercise‐Like Contractions Rapidly Promote Muscle Health Via Lamtor1's Signaling to Both AMPK and mTOR

Advanced Science, EarlyView.
This study develops a novel 3D human skeletal muscle organoid platform to study the immediate molecular effects of exercise‐like contractions. The model uncovers rapid proteomic and transcriptomic responses, resolving a fundamental paradox by demonstrating how exercise‐induced Lamtor1 coordinately activates both AMPK and mTORC1. Lamtor1 is a compelling
Ziyue Yao, Zongmin Jiang, Xupeng Liu, Liping Zhang, Siyu Guo, Yu Chen, Lanfang Luo, Shilin Ma, Peng Wang, Ng Shyh‐Chang   +9 more
wiley   +1 more source

Valor prognóstico da troponina I de alta sensibilidade versus troponina T nas síndromes coronarianas agudas Prognostic value of high-sensitivity troponin I versus troponin T in acute coronary syndromes

Arquivos Brasileiros de Cardiologia, 2012
FUNDAMENTO: Apesar da superior precisão diagnóstica das troponinas cardíacas de alta sensibilidade, seu valor prognóstico ainda não foi validado contra troponinas cardíacas convencionais.
Luis Cláudio Lemos Correia, Fábio L. Sodré, José C.C. Lima, Michael Sabino, Mariana Brito, Guilherme Garcia, Mayara Maraux, Alexandre C. Sousa, Márcia Noya Rabelo, J. Péricles Esteves   +9 more
doaj  

Multicenter comparison of four contemporary sensitive troponin immunoassays [PDF]

Journal of Medical Biochemistry, 2014
Background: The IFCC Task Force on Clinical Applications of Cardiac Biomarkers currently recommends evaluation of all troponin immunoassays within the same population to compare their performance. Hence, we planned a multicenter study to compare the four
Luca Salvagno Gian, Giavarina Davide, Meneghello Moira, Musa Roberta, Aloe Rosalia, da Rin Giorgio, Lippi Giuseppe   +6 more
doaj  

FMO2 Promotes Angiogenesis via Regulation of N‐Acetylornithine

Advanced Science, EarlyView.
This study identifies flavin‐containing monooxygenase 2 (FMO2) as a novel proangiogenic regulator in endothelial cells. Targeted FMO2 ablation impairs vessel sprouting, whereas its compensation potently enhances angiogenesis. Metabolomics and single‐cell sequencing reveal that FMO2 drives vascular growth via the N‐acetylornithine/ATF3/NOTCH1 axis ...
Jingyi Wang, Yinghui Xu, Xianpeng Wu, Mo Li, Changchen Xiao, Zaiyang Fu, Yongjian Chen, Qingju Li, Yating Ruan, Jing Zhao, Zhiwei Zhong, Jinghai Chen, Wei Zhu, Jinliang Nan, Cheng Ni, Xinyang Hu   +15 more
wiley   +1 more source

Inhibition of Macrophage ARID3A Alleviates Myocardial Ischemia‐Reperfusion Injury After Heart Transplantation by Reducing THBS1/CD47 Signaling‐Mediated Neutrophil Extracellular Traps Formation

Advanced Science, EarlyView.
This study reveals that ARID3A in macrophages can transcriptionally regulate the THBS1‐CD47 axis after heart transplantation (HT), thereby inducing activated neutrophils to release NETs through the p38 MAPK signaling pathway. The itaconate derivative 4‐OI can inhibit ARID3A in macrophages and promote the accumulation of antioxidant factors, thereby ...
Hao Tian, Yonghong Xiong, Junbiao Zhan, Zhikun Lu, Yuxi Zhang, Yan Leng, Qin Huang, Zhongyuan Xia   +7 more
wiley   +1 more source

Logistic Regression and Machine Learning Algorithms for the Risk Prediction of Perioperative Adverse Cardiovascular Events in Elderly Patients

AGING MEDICINE, EarlyView.
This manuscript focused on developing and validating prediction models for PACEs in elderly patients undergoing noncardiac surgery in China, utilizing routine laboratory examination findings. Logistic regression and machine learning algorithms were employed to construct these models.
Xiao Yan Li, Guang You Duan, Lin Li, Yi Yuan Gao, Li Wen Sun, Silin Zhu, Xiyezi Diao, Ning Wang, He Huang   +8 more
wiley   +1 more source

Genetically Encoded Biosensors Reveal PKA Hyperphosphorylation on the Myofilaments in Rabbit Heart Failure [PDF]

, 2016
RATIONALE: In heart failure, myofilament proteins display abnormal phosphorylation, which contributes to contractile dysfunction. The mechanisms underlying the dysregulation of protein phosphorylation on myofilaments is not clear.
Barbagallo, Federica, Bers, Donald, Bossuyt, Julie, Ferrier, William, Fu, Qin, Ginsburg, Kenneth S., Isidori, Andrea, Li, Minghui, Naro, Fabio, Patel, Hemal H., Reddy, Gopireddy R., Shi, Qian, Wang, Qingtong, West, Toni, Xiang, Yang K., Xu, Bing   +15 more
core   +1 more source