Results 181 to 190 of about 159,062 (216)
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Biochemical and Biophysical Research Communications, 2008
The troponin complex was discovered over thirty years ago and since then much insight has been gained into how this complex senses fluctuating levels of Ca(2+) and transmits this signal to the myofilament. Advances in genetics methods have allowed identification of mutations that lead to the phenotypically distinct cardiomyopathies: hypertrophic ...
Audrey N, Chang +2 more
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The troponin complex was discovered over thirty years ago and since then much insight has been gained into how this complex senses fluctuating levels of Ca(2+) and transmits this signal to the myofilament. Advances in genetics methods have allowed identification of mutations that lead to the phenotypically distinct cardiomyopathies: hypertrophic ...
Audrey N, Chang +2 more
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Biochimica et Biophysica Acta (BBA) - Protein Structure, 1969
Abstract Troponin was isolated from preparations of the ethylene glycol bis-(β-aminoethyl ether)-N,N′-tetraacetic acid (EGTA)-sensitizing factor over the pH range of 3.5–4.6. The variations among troponins were due essentially to differences in the proportion and properties of the troponin A component.
D J, Hartshorne, M, Theiner, H, Mueller
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Abstract Troponin was isolated from preparations of the ethylene glycol bis-(β-aminoethyl ether)-N,N′-tetraacetic acid (EGTA)-sensitizing factor over the pH range of 3.5–4.6. The variations among troponins were due essentially to differences in the proportion and properties of the troponin A component.
D J, Hartshorne, M, Theiner, H, Mueller
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The mobility of troponin C and troponin I in muscle
Journal of Molecular Recognition, 1997In vertebrate skeletal muscle, contraction is initiated by the elevation of the intracellular Ca2+ concentration. The binding of Ca2+ to TnC induces a series of conformational changes which ultimately release the inhibition of the actomyosin ATPase activity by Tnl.
H C, Li, K, Hideg, P G, Fajer
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NMR analysis of cardiac troponin C-troponin I complexes: effects of phosphorylation
FEBS Letters, 1999 Phosphorylation of the cardiac specific amino-terminus of troponin I has been demonstrated to reduce the Ca2+ affinity of the cardiac troponin C regulatory site.
Natosha L Finley +2 more
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Clinica Chimica Acta
Cardiac troponin (cTn) testing plays a crucial role in the diagnosis of cardiovascular diseases, particularly acute coronary syndrome (ACS), which includes acute myocardial infarction (AMI). However, conventional immunoassays may be subject to interference from autoantibodies, cross-reactivity, and biotin-related effects, compromising diagnostic ...
Yumeng Gao +7 more
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Cardiac troponin (cTn) testing plays a crucial role in the diagnosis of cardiovascular diseases, particularly acute coronary syndrome (ACS), which includes acute myocardial infarction (AMI). However, conventional immunoassays may be subject to interference from autoantibodies, cross-reactivity, and biotin-related effects, compromising diagnostic ...
Yumeng Gao +7 more
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Heart, Lung and Circulation, 2007
Serum Troponin is a sensitive and specific marker of heart muscle damage that is widely used in the assessment of people with chest pain. Its usefulness is, however, sometimes limited by false positive or negative results caused by proteins or fibrin in the patient's blood. More importantly, there is no agreed Troponin I standard at present which means
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Serum Troponin is a sensitive and specific marker of heart muscle damage that is widely used in the assessment of people with chest pain. Its usefulness is, however, sometimes limited by false positive or negative results caused by proteins or fibrin in the patient's blood. More importantly, there is no agreed Troponin I standard at present which means
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1999
Abstract Troponin (Tn) (for reviews see refs 1-6) is a complex of three subunits: troponin C (TnC), troponin I (Tnl), and troponin T (TnT); together with tropomyosin (TM) it constitutes the Ca2+- dependent regulatory machinery located in the actin filaments of striated muscle.
John Gergely +2 more
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Abstract Troponin (Tn) (for reviews see refs 1-6) is a complex of three subunits: troponin C (TnC), troponin I (Tnl), and troponin T (TnT); together with tropomyosin (TM) it constitutes the Ca2+- dependent regulatory machinery located in the actin filaments of striated muscle.
John Gergely +2 more
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Fukuoka igaku zasshi = Hukuoka acta medica, 1994
The substitution of troponin in bullfrog skeletal myofibrils by rabbit skeletal troponin, troponin T and troponin T1 was examined by the densitometry of the SDS gel-electrophoretic patterns. The troponin in the myofibrils was replaced by the added rabbit skeletal troponin and troponin T (tropomyosin binding component of troponin) to almost the same ...
F, Shiraishi +3 more
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The substitution of troponin in bullfrog skeletal myofibrils by rabbit skeletal troponin, troponin T and troponin T1 was examined by the densitometry of the SDS gel-electrophoretic patterns. The troponin in the myofibrils was replaced by the added rabbit skeletal troponin and troponin T (tropomyosin binding component of troponin) to almost the same ...
F, Shiraishi +3 more
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The Twilight Zone of Troponins
Heart Lung <html_ent glyph="@amp;" ascii="&"/> Circulation, 2003Since its introduction into the clinical environment in the early nineties, the cardiac enzyme troponin has significantly changed the way we diagnose and manage acute coronary syndromes. Troponin I is a biochemical marker of myocardial injury with a high level of specificity and sensitivity.
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