Results 41 to 50 of about 208,458 (261)
The Solution Structure of a Cardiac Troponin C−Troponin I−Troponin T Complex Shows a Somewhat Compact Troponin C Interacting with an Extended Troponin I−Troponin T Component [PDF]
Biochemistry, 2002 We have investigated the structure of the cTnC-cTnI-cTnT(198-298) calcium-saturated, ternary cardiac troponin complex by small-angle scattering with contrast variation. Shape restoration was also applied to the scattering information resulting from the deuterated cTnC subunit, the unlabeled cTnI-cTnT(198-298) subunits, and the entire complex.
William T, Heller +4 more
openaire +2 more sources
3D Bioprinted Fat‐Myocardium Model Unravels the Role of Adipocyte Hypertrophy in Atrial Dysfunction
Advanced Science, EarlyView.A human‐derived 3D bioprinted fat–myocardium model is developed to investigate how adipocyte hypertrophy drives atrial dysfunction in obesity. Palmitate‐induced adipocyte hypertrophy promotes adipose dysfunction that impairs atrial cardiomyocyte metabolism and electrophysiology through both paracrine and direct interactions. This platform recapitulates
Lara Ece Celebi, Pinar Zorlutuna
wiley +1 more source
Contemporary NSTEMI management: the role of the hospitalist. [PDF]
, 2019 Non-ST-segment elevation myocardial infarction (NSTEMI) is defined as elevated cardiac biomarkers of necrosis in the absence of persistent ST-segment elevation in the setting of anginal symptoms or other acute event.
Amin, Alpesh +9 more
core +1 more source
European Heart Journal, 2016 This editorial refers to ‘Impact of high-sensitivity cardiac troponin on use of coronary angiography, cardiac stress testing, and time to discharge in suspected acute myocardial infarction’, by R. Twerenbold et al. doi:10.1093/eurheartj/ehw232. Equipose ( noun | equi·poise | \e-kwə-p⊙iz, ē-\): a state of equilibrium1Well-executed clinical trials have ...
openaire +2 more sources
Location of troponin I‐binding on troponin T sequence [PDF]
FEBS Letters, 1982 Interaction between troponin T and troponin I is considered as one of those necessary for the calI cium-regulatory mechanism in the thin filament of vertebrate striated muscles [ 1,2]. Studies using chymotryptic subfragments of troponin T showed that the affinity for troponin I is localized in the region of the C-terminal 101 residues, termed troponin ...
Tanokura, Masaru, Ohtsuki, Iwao
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Advanced Science, EarlyView.We delineate a TGFβ1/SMAD/lnc‐APUE/E‐cadherin axis wherein TGFβ1 signaling activates lnc‐APUE; lnc‐APUE subsequently downregulates E‐cadherin expression via Alu element‐driven STAU1‐mediated decay of CDH1 mRNA, thereby promoting tumor metastasis. Our findings reveal a novel regulatory function for lnc‐APUE within the SMD pathway, elucidate a distinct ...
Song‐Yang Li +10 more
wiley +1 more source
Thyroid Hormone as a Method of Reducing Damage to Donor Hearts after Circulatory Arrest [PDF]
, 2017 There is a chronic lack of donor hearts to meet the need for heart transplant both in the US and worldwide. Further, the use of available hearts is limited by the short period between collection and implantation during which the heart can be safely ...
Adams, William P.
core +1 more source
ST2 in Stable and Unstable Ischemic Heart Diseases [PDF]
, 2015 Circulating suppression of tumorigenicity 2 (ST2) predicts cardiovascular outcomes and mortality in ischemic heart disease (IHD). ST2 does not correlate with traditional risk indicators as closely as N-terminal pro–brain natriuretic peptide (NT-proBNP ...
DI SOMMA, Salvatore +2 more
core +1 more source
Advanced Science, EarlyView.This study highlights that radioimmunotherapy drives crosstalk between fibroblasts and immune cells (especially macrophages) in the cardiac microenvironment, with IL‐6 as the key mediator, and tocilizumab alleviates cardiac fibrosis by targeting this interplay.
Yuxi Luo +10 more
wiley +1 more source
Quantifying the risk of heart disease following acute ischaemic stroke: a meta-analysis of over 50 000 participants [PDF]
, 2015 Objective Following an acute stroke, there is a high risk of recurrence. However, the leading cause of mortality following a stroke is due to coronary artery disease (CAD) and myocardial infarction (MI) but that risk has not been robustly quantified.
Bentley, P +5 more
core +1 more source