Results 51 to 60 of about 159,062 (216)

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito, Kamal Benguerba, Ken Tsuchida, Kazushige Yazawa, Isao Tsumiyama, Hiromitsu Kayama, Sandra P. Reyna, Farid Khan, Richard S. Finkel   +8 more
wiley   +1 more source

High sensitivity troponins and conventional troponins at the bedside

International Journal of Critical Illness and Injury Science, 2014
The continuing advances in the biochemical research for the discovering an ideal biomarker for diagnosing myocardial injury have led to discovery cardiac Troponin, a biochemical gold standard for myocardial necrosis. Further with advances in the immunoassay techniques, the 99th percentile cutoff value of cardiac troponin required for the diagnosis of ...
Bhoi, Sanjeev, Verma, Pankaj, Vankar, Sameer, Galwankar, Sagar   +3 more
openaire   +3 more sources

Genetically Encoded Calcium Indicators Based on Troponin C and Fluorescent Proteins [PDF]

, 2005
Genetically encoded calcium probes allow the visualization and quantification of intracellular calcium dynamics with great specificity and sensitivity.
Heim, Nicola, Heim, N.
core  

Comparison between the protective effect of the orally administered atorvastatin and safflower (Carthamus tinctorius) in hypercholesterolemic male rats

Frontiers in Pharmacology
Hyperlipidemia is correlated with the elevation of cholesterol and triglyceride levels in the blood that increase the risk of cardiovascular events, such as heart attacks and strokes.
Haddad A. El Rabey, Eman S. Attia, Eman S. Attia, Nadia Bakry, Samar M. Rezk, Asmaa Y. Sharfeldin   +5 more
doaj   +1 more source

Development of a sensitive immunosensor for the detection of cardiac Troponin T in cardiovascular disease [PDF]

, 2014
Cardiovascular disease (CVD) is currently globally the biggest cause of mortality, with rising figures, especially now in the developing world. Early and accurate diagnosis of CVD, (especially acute myocardial infarction (AMI) is important in being able ...
Pawula, Maria
core  

Evaluation of the Use of Different Sensitive Cardiac Biomarkers in Determining Myocardial Damage in Cows With Subclinical and Clinical Ketoses

Veterinary Medicine and Science
Background It is unclear whether the increase in BHBA concentration damages the myocardium in ketotic cows. Measurement of troponin is the gold standard in myocardial injury.
Murat Uztimür, Cennet Nur Ünal, Meltem Sağiroğlu   +2 more
doaj   +1 more source

Cardiac troponins in intensive care

, 2005
The cardiac troponins are integral components of the myofibrillary apparatus and they regulate muscle contraction. The measurement of cardiac troponins has replaced other biomarkers for the specific detection of myocardial necrosis and for the diagnosis ...
Collinson, P.O., Gaze, D.C., Collinson, P, Gaze, D   +3 more
core   +1 more source

Troponin destabilization impairs sarcomere-cytoskeleton interactions in iPSC-derived cardiomyocytes from dilated cardiomyopathy patients

, 2020
The sarcomeric troponin-tropomyosin complex is a critical mediator of excitation-contraction coupling, sarcomeric stability and force generation. We previously reported that induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) from patients ...
Zimmermann, Wolfram-Hubertus, Dai, Yuanyuan, Koschinski, Andreas, Xu, Hang, Soong, Poh Loong, Tiburcy, Malte, Zaccolo, Manuela, Ebert, Antje, Hasenfuss, Gerd, Linke, Wolfgang A., Amenov, Asset, Ignatyeva, Nadezda   +11 more
core   +1 more source

Cardiac biomarkers for screening and prognostication of cardiac dysfunction in critically ill patients

ESC Heart Failure
Aims This study aimed to assess the use of high‐sensitivity troponin T (hsTNT) and N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) in screening for cardiac dysfunction [left ventricular (LV) systolic or diastolic dysfunction or right ventricular (RV)
Oscar Cavefors, Freyr Einarsson, Jakob Holmqvist, Odd Bech‐Hanssen, Sven‐Erik Ricksten, Björn Redfors, Jonatan Oras   +6 more
doaj   +1 more source

Liver parameters as part of a non-invasive model for prediction of all-cause mortality after myocardial infarction

Archives of Medical Science, 2019
Introduction Liver parameters are associated with cardiovascular disease risk and severity of stenosis. It is unclear whether liver parameters could predict the long-term outcome of patients after acute myocardial infarction (AMI).
Theodor Baars, Jan-Peter Sowa, Ursula Neumann, Stefanie Hendricks, Mona Jinawy, Julia Kälsch, Guido Gerken, Tienush Rassaf, Dominik Heider, Ali Canbay   +9 more
doaj   +1 more source