Results 81 to 90 of about 238,995 (362)

Troponins in equipoise [PDF]

European Heart Journal, 2016
This editorial refers to ‘Impact of high-sensitivity cardiac troponin on use of coronary angiography, cardiac stress testing, and time to discharge in suspected acute myocardial infarction’, by R. Twerenbold et al. doi:10.1093/eurheartj/ehw232. Equipose ( noun | equi·poise | \e-kwə-p⊙iz, ē-\): a state of equilibrium1Well-executed clinical trials have ...
openaire   +2 more sources

Location of troponin I‐binding on troponin T sequence [PDF]

FEBS Letters, 1982
Interaction between troponin T and troponin I is considered as one of those necessary for the calI cium-regulatory mechanism in the thin filament of vertebrate striated muscles [ 1,2]. Studies using chymotryptic subfragments of troponin T showed that the affinity for troponin I is localized in the region of the C-terminal 101 residues, termed troponin ...
Tanokura, Masaru, Ohtsuki, Iwao
openaire   +2 more sources

F‐Box and Leucine‐Rich Repeat Protein 4 (FBXL4) Maintains Sarcomere Integrity and Cardiac Function by Enhancing K48‐Linked Ubiquitinated Degradation of Profilin‐1 (PFN1)

Advanced Science, EarlyView.
Schematic diagram depicting the proposed signaling mechanisms underlying the effects of FBXL4 in the setting of cardiac hypertrophy. Under hypertrophic stimulation, cardiomyocytes‐specific overexpression FBXL4 maintains sarcomere integrity and cardiac function by enhancing K48‐linked ubiquitinated degradation of PFN1 at the K70 site.
Xingda Li, Xueqi He, Xinyuan Hao, Yu Zhang, Xin Zhao, Shuang Wang, Zhenru Wang, Haonan Du, Hongda Li, Lian Yi, Zhimin Du, Weijie Du   +11 more
wiley   +1 more source

Specifics of acute coronary syndrome associated with atrial fibrillation in real world clinical practice (based on the registry of the Krasnodar Region)

Alʹmanah Kliničeskoj Mediciny, 2018
Background: Coronary heart disease is the most common cardiovascular disorder, while atrial fibrillation (AF) is the most common heart arrhythmia.Aim: To perform a comparative analysis of the coronary substrate assessed by coronary angiography in ...
Z. G. Tatarintseva, E. D. Kosmacheva, S. A. Raff, S. V. Kruchinova, V. A. Porkhanov   +4 more
doaj   +1 more source

Metformin for non-diabetic patients with coronary heart disease (the CAMERA study): a randomised controlled trial [PDF]

, 2009
<br>Background: Metformin reduces cardiovascular risk in patients with type 2 diabetes seemingly independent of lowering blood glucose concentration. We assessed the cardiovascular effects of metformin in individuals without type 2 diabetes.</br&
Eddy, Despres, Grundy, Bird, Seifarth, Nathan, Fontbonne, Charles, Holman, Kooy, Knowler, Alberti, Vergeer, Touboul, Liang, Spence, Levey, Meaney, Taylor, Selvin, Boussageon, Sjöström, Shyangdan, de Jager, Bots, Taylor, Boden, Huang, Baigent, Lorenz, Mazzone, Taylor, Lonn, Lexis   +33 more
core   +5 more sources

Crossing the Blood–Brain Barrier with Molecularly Imprinted Polymeric Nanocarriers: An Emerging Frontier in Brain Disease Therapy

Advanced Science, EarlyView.
Molecularly imprinted polymeric nanocarriers (nanoMIPs) offer robust, antibody‐mimetic platforms to overcome the blood‐brain barrier. The article surveys nanoMIP design and ligand‐directed surface engineering that harness receptor‐mediated transcytosis, and highlights therapeutic and diagnostic applications in neurodegeneration, brain tumors and ...
Ranjit De, Shuliang Shi, Kyong‐Tai Kim
wiley   +1 more source

Discrepancy between Cardiac Troponin Assays Due to Endogenous Antibodies [PDF]

, 2020
Leo Lam, Lisa Aspin, Robert Campbell Heron, Leah Ha, Campbell Kyle   +4 more
openalex   +1 more source

OCTN2 Activates a Non‐Canonical Carnitine Metabolic Pathway to Promote MASH‐HCC Progression and Immunotherapy Resistance

Advanced Science, EarlyView.
In non‐MASH‐HCC, L‐carnitine promotes tumor progression primarily through its classical role in enhancing fatty acid oxidation (FAO). However, in MASH‐HCC, where FAO is markedly suppressed, L‐carnitine shifts from this canonical function to serve instead as an intracellular acetyl group buffer.
Chuqi Xia, Xiao Zhang, Jinze Li, Ning Xu, Sheng Hu, Qiyu Lu, Yuxuan Li, Taifu Xiao, Xu Li, Xue Wang, Kequan Xu, Daoming Liang   +11 more
wiley   +1 more source

A Comparison Study: Possible Bias in Troponin I Measurement Obtained with a Point of Care Testing and a Central Laboratory Analyzers Employing Different Biological Matrices and Anticoagulants

Diagnostics
Background: high-sensitive cardiac TroponinI (hs-cTnI) is widely used for diagnosis of acute coronary syndromes. The latest recommendation for hs-cTnI determination is the protocol 0–1 h finalized to improve the rule out accuracy of the test.
Antonino Sammartano, Ruggero Buonocore, Roberto Fiorini, Elisabetta Dieci, Anna Di Franco, Bruna Di Stasi, Giovanni Tortorella, Luigi Ippolito   +7 more
doaj   +1 more source

Liver parameters as part of a non-invasive model for prediction of all-cause mortality after myocardial infarction

Archives of Medical Science, 2019
Introduction Liver parameters are associated with cardiovascular disease risk and severity of stenosis. It is unclear whether liver parameters could predict the long-term outcome of patients after acute myocardial infarction (AMI).
Theodor Baars, Jan-Peter Sowa, Ursula Neumann, Stefanie Hendricks, Mona Jinawy, Julia Kälsch, Guido Gerken, Tienush Rassaf, Dominik Heider, Ali Canbay   +9 more
doaj   +1 more source