Results 161 to 170 of about 162,145 (312)

TET3‐Mediated m5C Modification of CCAT2 Accelerates Cardiac Microvascular Endothelial Cell Damage in Acute Coronary Syndrome

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Acute coronary syndrome (ACS) is a clinical syndrome involving myocardial ischemia. This study aimed to elucidate the mechanism of TET3 in ACS‐induced CMEC damage, thereby identifying a new target for ACS treatment. The expression of TET3 in ACS patients and healthy subjects was analyzed.
Jun‐Cheng Liu, Wen‐Juan Wang, Ting‐Ting Zhang, Qi‐Chong Yang, Haliminai Dilimulati, Song‐Tao An   +5 more
wiley   +1 more source

Deubiquitinase USP7 Regulates Neutrophil Extracellular Trap Formation and Inflammation in Lipopolysaccharide‐Treated Mice Through ICAM‐1 Expression

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Sepsis is typified by organ failure due to an unchecked host reaction to infection. This study aims to explore the mechanism of ubiquitin‐specific peptidase 7 (USP7) in sepsis with the involvement of intercellular adhesion molecule‐1 (ICAM‐1).
Hui Xu, Qi Wang, Jing‐Xian Fan, Yong‐Fu Xu, Jiao Yu   +4 more
wiley   +1 more source

Multiple Inflammatory Prognostic Factors in Acute Coronary Syndromes: A Prospective Inception Cohort Study

Acta Medica Iranica, 2010
Inflammatory basis in pathopoiesis of coronary artery disease (CAD) have been demonstrated in recent decades. Elevated C-Reactive Protein (CRP) and leukocytosis were associated with an elevated risk  for acute coronary syndrome (ACS).
Zinat Nadia Hatmi, Ali Kazemi Saeid, Mohammad Ali Broumand, Shabnam Najar Khoshkar, Zahra Fakher Danesh   +4 more
doaj  

Bright Ferritin for Non‐Invasive MRI Monitoring of the Fate of Transplanted hPSC‐Cardiomyocytes in the Infarcted Rat Heart

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To demonstrate that a recently reported bright ferritin magnetic resonance imaging (MRI) platform can track transplanted human pluripotent stem cell (hPSC)‐derived cardiomyocytes (hPSC‐CMs) longitudinally and on‐demand in the rat heart.
Keyu Zhuang, Faisal J. Alibhai, Beiping Qiang, Rocco Romagnuolo, Kyle D. W. Vollett, Bradley K. C. Freeman, M. Juliana Gomez‐Garcia, Tamilla Sadikov Valdman, Tameshwar Ganesh, Yu‐Qing Zhou, Hai‐Ying Mary Cheng, Michael A. Laflamme, Hai‐Ling Margaret Cheng   +12 more
wiley   +1 more source

Development and Validation of a Nomogram Incorporating Preoperative N‐Terminal Pro‐Brain Natriuretic Peptide to Predict Major Adverse Cardiovascular Events in Renal Transplant Recipients

Organ Medicine, EarlyView.
We developed and validated a preoperative nomogram incorporating NT‐proBNP to predict major adverse cardiovascular events in renal transplant recipients. Using a LASSO‐Cox model based on 582 training and 181 validation cases, we identified NT‐proBNP, age, body mass index, diabetes, and retransplantation as key predictors.
Guobin Wu, Chang Wang, Qihao Li, Shuangjin Yu, Linjie Peng, Jianliang Min, Weijie Lai, Haiwei Chen, Jiang Qiu, Guodong Chen   +9 more
wiley   +1 more source

Valor prognóstico da troponina I de alta sensibilidade versus troponina T nas síndromes coronarianas agudas Prognostic value of high-sensitivity troponin I versus troponin T in acute coronary syndromes

Arquivos Brasileiros de Cardiologia, 2012
FUNDAMENTO: Apesar da superior precisão diagnóstica das troponinas cardíacas de alta sensibilidade, seu valor prognóstico ainda não foi validado contra troponinas cardíacas convencionais.
Luis Cláudio Lemos Correia, Fábio L. Sodré, José C.C. Lima, Michael Sabino, Mariana Brito, Guilherme Garcia, Mayara Maraux, Alexandre C. Sousa, Márcia Noya Rabelo, J. Péricles Esteves   +9 more
doaj  

6‐Shogaol Attenuates Doxorubicin‐Induced Cardiac and Skeletal Muscle Atrophy by Inhibiting E3 Ubiquitin Ligases and Necroptosis

Phytotherapy Research, EarlyView.
Doxorubicin induces cardiac and skeletal muscle atrophy by upregulating E3 ubiquitin ligases, inhibiting myogenic regulatory factors, and activating necroptosis. Cardiac atrophy can further exacerbate cardiotoxicity. 6‐Shogaol negatively regulates these processes and attenuates doxorubicin‐induced cardiac and skeletal muscle atrophy.
Xipeng Sun, Yaxian Wang, Quanjun Yang, Bo Xin, Jinlu Huang, Cheng Guo   +5 more
wiley   +1 more source

Cardio-Renal Biomarker Soluble Urokinase-Type Plasminogen Activator Receptor Is Associated With Cardiovascular Death and Myocardial Infarction in Patients With Coronary Artery Disease Independent of Troponin, C-Reactive Protein, and Renal Function. [PDF]

J Am Heart Assoc, 2020
Nikorowitsch J, Borchardt T, Appelbaum S, Ojeda F, Lackner KJ, Schnabel RB, Blankenberg S, Zeller T, Karakas M.   +8 more
europepmc   +1 more source

Cardiac disease in systemic sclerosis: Integrating pathobiology with clinical management

Rheumatology &Autoimmunity, EarlyView.
Abstract Systemic sclerosis (SSc) is a complex autoimmune disorder in which cardiovascular involvement remains a major determinant of morbidity and mortality. Cardiac injury in SSc results from the interplay of microvascular dysfunction, immune‐mediated inflammation, and progressive interstitial and replacement fibrosis, leading to myocardial disease ...
Henry Sutanto, Betty Rachma, Yuliasih
wiley   +1 more source

Cardiac Troponin C E135A Variant Impairs Myofilament Response to PKA Phosphorylation and Is Associated With Autosomal Dominant Dilated Cardiomyopathy With Diastolic Dysfunction. [PDF]

Circ Genom Precis Med
Landim-Vieira M, Perelli RM, Rodriguez-Garcia M, Jani VP, Chastain RC, Lamar JH, Mines E, Seo G, Araujo Fernandes A, Knollmann B, Carboni MP, Chelko SP, Galkin VE, Chase PB, Pinto JR, Landstrom AP.   +15 more
europepmc   +1 more source