Results 301 to 310 of about 19,667,204 (333)

Defining the Region of Troponin-I that Binds to Troponin-C

Biochemistry, 1999
The kinetics and energetics of the binding of three troponin-I peptides, corresponding to regions 96-131 (TnI96-131), 96-139 (TnI96-139), and 96-148 (TnI96-148), to skeletal chicken troponin-C were investigated using multinuclear, multidimensional NMR spectroscopy.
Ryan T. McKay, Lawrence B. Smillie, Brian Tripet, Joyce R. Pearlstone, Brian D. Sykes   +4 more
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Troponin T fragments: Physical properties and binding to troponin C

Canadian Journal of Biochemistry, 1978
Fragments derived from rabbit skeletal troponin T (Tn-T) were tested for binding on a troponin C (Tn-C) – Sepharose affinity column in order to locate the binding site of Tn-C on Tn-T. The COOH-terminal fragments P2 (residues 159–209) and B2 (residues 206–258) were found to bind most strongly, confirming the earlier proposal (Pearlstone, J.
Lawrence B. Smillie, Joyce R. Pearlstone
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The characterization of invertebrate troponin C

Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1984
TNCs from lobster, mussel, and squid migrated with rabbit TNC at an apparent mol. wt of 18,000. Electrophoretic mobilities in the presence or absence of Ca2+ were compared: the electrophoretic mobility of rabbit TNC was greater in the presence of Ca2+ than it its absence, but all invertebrate TNCs tested migrated identically, whether Ca2+ was present ...
Yukio Shima, William Lehman, Juichiro J. Matsumoto, Takahide Tsuchiya   +3 more
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Phosphorylation of troponin I by protein kinase C: Mechanism of inhibition by calmodulin and troponin C

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1987
The mechanism by which calmodulin and troponin C influence phosphorylation of troponin I (TnI) by protein kinase C was investigated. The phosphorylation of TnI by protein kinase C requires the presence of acidic phospholipid, calcium and diacylglycerol.
Paul D. Lampe, Gale M. Strasburg, Gary L. Nelsestuen, Mohammad D. Bazzi   +3 more
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Structural and functional studies on Troponin I and Troponin C interactions

Journal of Cellular Biochemistry, 2001
AbstractTroponin I (TnI) peptides (TnI inhibitory peptide residues 104–115, Ip; TnI regulatory peptide resides 1–30, TnI1–30), recombinant Troponin C (TnC) and Troponin I mutants were used to study the structural and functional relationship between TnI and TnC.
S M, Ngai, J R, Pearlstone, C S, Farah, F C, Reinach, L B, Smillie, R S, Hodges   +5 more
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The Molecular Switch in Troponin C

1993
Conformational changes in troponin C (TnC) associated with Ca(2+)-induced triggering of muscle contraction are discussed in light of the model proposed by Herzberg, Moult and James (J. Biol. Chem. 261, 2638, 1986) and of our recent work on mutants of troponin C.
John Gergely, Terence Tao, Zenon Grabarek   +2 more
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Extensive Interactions Between Troponins C and I. Zero-Length Footnotes: Crosslinking Of Troponin I and Acetylated Troponin C

Biochemistry, 1995
Interactions between troponin C (TnC) and troponin I (TnI) play an important role in the Ca(2+)-dependent regulation of vertebrate striated muscle contraction. Earlier studies have led to the proposal that the "inhibitory region" (residues 96-116) of TnI binds to an alpha-helical segment of TnC comprising residues 89-100 in the nonregulatory, C ...
John H. Collins, John Gergely, Tomoyoshi Kobayashi, Zenon Grabarek   +3 more
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Interaction of troponin I and troponin C: ¹⁹F NMR studies of the binding of the inhibitory troponin I peptide to turkey skeletal troponin C

Biochemistry and Cell Biology, 1991
We have used 19F nuclear magnetic resonance spectroscopy to study the interaction of the inhibitory region of troponin (TnI) with apo- and calcium(II)-saturated turkey skeletal troponin C (TnC), using the synthetic TnI analogue Nα-acetyl[19FPhe106]TnI(104–115)amide.
Paul J. Cachia, Brian D. Sykes, A. Patricia Campbell   +2 more
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Functional and evolutionary relationships of troponin C [PDF]

Physiological Genomics, 2007
Striated muscle contraction is initiated when, following membrane depolarization, Ca2+binds to the low-affinity Ca2+binding sites of troponin C (TnC). The Ca2+activation of this protein results in a rearrangement of the components (troponin I, troponin T, and tropomyosin) of the thin filament, resulting in increased interaction between actin and myosin
Todd E. Gillis, Glen F. Tibbits, Glen F. Tibbits, Christian R. Marshall   +3 more
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Proximity Relationships between Residue 6 of Troponin I and Residues in Troponin C:  Further Evidence for Extended Conformation of Troponin C in the Troponin Complex

Biochemistry, 2000
Skeletal muscle troponin C (TnC) adopts an extended conformation when crystallized alone and a compact one when crystallized with an N-terminal troponin I (TnI) peptide, TnI(1-47) [Vassylyev et al. (1998) Proc. Natl. Acad. Sci. U.S.A. 95, 4847-4852]. The N-terminal region of TnI (residues 1-40) was suggested to play a functional role of facilitating ...
John D. Leszyk, John Gergely, Bing Li, Yin Luo, Terence Tao   +4 more
openaire   +3 more sources