Results 111 to 120 of about 6,673,815 (394)

MMP9High Neutrophils are Critical Mediators of Neutrophil Extracellular Traps Formation and Myocardial Ischemia/Reperfusion Injury

Advanced Science, EarlyView.
During a heart attack, neutrophils rapidly activate and differentiate into a specific subset characterized by high levels of MMP9, a tissue‐damaging enzyme, via the SPI1/CST7 pathway. These neutrophils form harmful net‐like structures (Neutrophil extracellular traps, NETs) that exacerbate heart injury.
Shiyu Hu, Feng Zhang, Jingpu Wang, Jian Zhang, Chenguang Li, Yang Lyu, Yiwen Wang, Rong Huang, Yang Gao, Hongbo Yang, Juying Qian, Wenwen Tang, Jiatian Cao, Junbo Ge   +13 more
wiley   +1 more source

Deep learning-enhanced paper-based vertical flow assay for high-sensitivity troponin detection using nanoparticle amplification [PDF]

ACS Nano (2024)
Successful integration of point-of-care testing (POCT) into clinical settings requires improved assay sensitivity and precision to match laboratory standards. Here, we show how innovations in amplified biosensing, imaging, and data processing, coupled with deep learning, can help improve POCT.
arxiv   +1 more source

The use of cardiac biomarkers in veterinary medicine: the equine perspective [PDF]

, 2012
In human medicine, cardiac biomarkers, such as natriuretic peptides and troponins, are routinely used for the diagnosis, prognosis and monitoring of heart diseases.
De Clercq, Dominique, Decloedt, Annelies, Van Der Vekens, Nicky, van Loon, Gunther, Verheyen, Tinne   +4 more
core   +1 more source

Utility of B-type natriuretic peptide in predicting medium-term mortality in patients undergoing major non-cardiac surgery [PDF]

, 2007
We assessed the ability of pre-operative B-type natriuretic peptide (BNP) levels to predict medium-term mortality in patients undergoing major noncardiac surgery.
Amiri, Amir R., Brittenden, Julie, Croal, Bernard L., Cuthbertson, Brian, Hillis, Graham S., Rajagopalan, Sriram   +5 more
core   +1 more source

Mitigating Doxorubicin‐Induced Cardiotoxicity and Enhancing Anti‐Tumor Efficacy with a Metformin‐Integrated Self‐Assembled Nanomedicine

Advanced Science, EarlyView.
A novel self‐assembled nanomedicine (PMDDH) has been developed for the co‐delivery of doxorubicin and metformin, aiming to enhance the anti‐tumor efficacy of doxorubicin while alleviating its cardiotoxicity through the activation of cGAS‐STING and AMPK signaling pathways, respectively.
Jiaxin Huang, Jieru Yang, Yuanying Yang, Xiaofeng Lu, Juan Xu, Shan Lu, Hong Pan, Wenhu Zhou, Wenqun Li, Songwen Chen   +9 more
wiley   +1 more source

Metal–Organic Frameworks: Unlocking New Frontiers in Cardiovascular Diagnosis and Therapy

Advanced Science, EarlyView.
Metal–organic frameworks (MOFs), are composed of metal ions and bridging organic ligands, are recognized as an excellent platform for host‐gust chemistry. Its rich structural composition, modifiable sites, and multilevel pore distribution can provide delivery and release of signaling molecules, probes, and therapeutic drugs, which exhibit great medical
Qilu Wu, Yuxiao Feng, Mathilde Lepoitevin, Meng Yu, Christian Serre, Jun Ge, Yuan Huang   +6 more
wiley   +1 more source

IMPACT (Information Medically Pertinent in Acute Computed Tomography) requests: Delphi study to develop criteria standards for adequate clinical information in computed tomography requests in the Australian emergency department

Journal of Medical Radiation Sciences, Volume 69, Issue 4, Page 421-430, December 2022., 2022
Currently, in Australia there are no published guidelines on what constitutes adequate clinical information in requests for Computed Tomography (CT). An e‐Delphi study was conducted to gain consensus from CT reporting consultant radiologists as to what constitutes adequate clinical information for patients presenting to the emergency department with ...
Chelsea Castillo, Tom Steffens, Georgia Livesay, Lawrence Sim, Liam Caffery   +4 more
wiley   +1 more source

Hypertrophic and Dilated Cardiomyopathy-Associated Troponin T Mutations R130C and ΔK210 Oppositely Affect Length-Dependent Calcium Sensitivity of Force Generation

Frontiers in Physiology, 2020
Length-dependent activation of calcium-dependent myocardial force generation provides the basis for the Frank-Starling mechanism. To directly compare the effects of mutations associated with hypertrophic cardiomyopathy and dilated cardiomyopathy, the ...
Marcel Groen, Alfredo Jesus López-Dávila, Stefan Zittrich, Gabriele Pfitzer, Robert Stehle   +4 more
doaj   +1 more source

The 99th percentile of reference population for cTnI and cTnT assay: Methodology, pathophysiology and clinical implications [PDF]

, 2017
According to recent international guidelines, including the 2012 Third Universal Definiton of Myocardial Infarction by the Joint ESC/ACCF/AHA/WHF Task Force, an increase in cardiac troponin (cTn) levels over the 99th percentile upper reference limit ...
Clerico, Aldo, Masotti, Silvia, Passino, Claudio, Plebani, Mario, Prontera, Concetta, Ripoli, Andrea, Zaninotto, Martina   +6 more
core   +1 more source

Dynamic Studies Of Truncated Troponin Complex Usin Hdx [PDF]

Biophysical Journal, 2009
Troponin is the primary control protein of the cardiac and skeletal muscle contractile apparatus. Troponin is made up of three subunits (TnT, TnI, TnC) and is located on the thin filament together with tropomyosin. The binding of Ca++ to TnC induces conformational changes in troponin leading to muscle contraction, via a regulatory mechanism that ...
Larry S. Tobacman, Dev Kowlessur
openaire   +2 more sources