Transcriptomic analysis of Ascaris suum larvae during their hepatopulmonary migration [PDF]
, 2012 Common roundworms are important intestinal nematodes of man (Ascaris lumbricoides) and pig (Ascaris suum). During the first stages of the infection, the larvae of these parasites undergo a hepatopulmonary migration.
Gasser, Robin +4 more
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A proposed role for sepsis in the pathogenesis of myocardial calcification [PDF]
, 2017 Myocardial calcification is a rare and life-threatening condition that is a recognised complication of ischaemic heart disease, cardiac surgery, rheumatic fever and myocarditis.
AROMATARIO, MARIAROSARIA +7 more
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Aggregate, EarlyView.Molecular confinement via polymer network allows for significant emission enhancement (80‐fold) of AIEgen with the exceptional quantum yield of 91%, and ultra‐stable photobleaching after continuous irradiation. Subsequently, by adjusting the filter bandwidth, remarkable signal amplification (2–10 folds) is achieved, and the sensitive detection was ...
Yaxin Hu +6 more
wiley +1 more source
A biomarker guided approach in heart failure [PDF]
, 2014 Heart failure is one of the commonest diagnoses presenting to physicians in the community or hospital care. Symptoms are often subjective, with clinicians having to rely on clinical assessment and radiological imaging to manage these patients.
Abela, Mark
core
Annals of Neurology, EarlyView.Objective Tofersen is the first effective and approved therapy for superoxide dismutase 1 (SOD1)‐associated amyotrophic lateral sclerosis (ALS [SOD1‐ALS]). Following treatment with tofersen, neurofilament levels in patients' cerebrospinal fluid (CSF) and serum seem to respond earlier than clinical parameters.
Christina Steffke +36 more
wiley +1 more source
Debate: Unstable angina - When should we intervene?
Current Controlled Trials in Cardiovascular Medicine, 2000 The prognosis of patients who present with non-ST segment elevation acute coronary syndromes (ACS) is guarded. These patients can be risk-stratified on the basis of symptom complex, electrocardiographic ST segment depression, obvious hemodynamic ...
Kereiakes Dean J
doaj +1 more source
Structure and dynamics of endogenous cardiac troponin complex in human heart tissue captured by native nanoproteomics. [PDF]
Nat Commun, 2023 Chapman EA +11 more
europepmc +1 more source
Tuning Cellular Perception in Pluripotent Stem Cells through Topography, Stiffness, and Patterning
Advanced NanoBiomed Research, EarlyView.Micro‐ and nanotopographical cues, substrate stiffness, and mechanical patterning synergistically direct pluripotent stem cell fate and function by tuning cellular perception at the biointerface. Pluripotent stem cells (PSCs), comprised of embryonic stem cells and induced PSCs, hold tremendous therapeutic potential.
Yuan Jiang +7 more
wiley +1 more source
The Role of the Calcium-Troponin-Tropomyosin Complex in the Activation of Contraction
Journal of Biological Chemistry, 1970 This paper considers the function of troponin-tropomyosin in the control of actomyosin contraction. The findings indicate that: (a) mild heat treatment, known to desensitize native actomyosin to calcium and to inhibit relaxation through the oxidation of certain —SH groups, acts by the oxidation of —SH groups on actomyosin per se, not on troponin ...
Harvey M. Levy, Judith M. Stewart
openaire +3 more sources
Intermolecular And Dynamic Investigation of The Mechanism of Action of Reldesemtiv on Fast Skeletal Muscle Troponin Complex Toward the Treatment of Impaired Muscle Function. [PDF]
Protein J, 2023 Issahaku AR +3 more
europepmc +1 more source