Results 111 to 120 of about 6,764,388 (368)
The Journal of General Physiology, 1986 Partial extraction of troponin C (TnC) decreases the Ca2+ sensitivity of tension development in mammalian skinned muscle fibers (Moss, R. L., G. G. Giulian, and M. L. Greaser. 1985. Journal of General Physiology.
R. Moss, J. Allen, M. Greaser
semanticscholar +1 more source
Antibody‐Empowered Nanomedicine for Precise Biomedical Applications
Advanced Science, EarlyView.This review explores strategies for functionalizing nanoparticles with antibodies to construct antibody‐empowered nanomedicine. It discusses the classification of these nanomedicines based on antibody structure, with a specific focus on their biomedical applications in diagnostics, bioimaging, and therapeutics for various diseases.
Chen Chen +7 more
wiley +1 more source
PLoS ONE, 2020 TNNI3 encoding cTnI, the inhibitory subunit of the troponin complex, is the main target for mutations leading to restrictive cardiomyopathy (RCM). Here we investigate two cTnI-R170G/W amino acid replacements, identified in infantile RCM patients, which ...
Diana Cimiotti +18 more
doaj +1 more source
Investigation of the effects of weight loss on Ovis aries muscle: a proteomic study on three breeds with different levels of adaptation to nutritional stress [PDF]
, 2011 Tese de mestrado. Biologia (Biologia Celular e Biotecnologia). Universidade de Lisboa, Faculdade de Ciências, 2011Nos trópicos, a produção animal em regime extensivo enfrenta grandes obstáculos, talvez o maior dos quais é a perda de peso sazonal, devida ...
Palhinhas, Rui MIguel Guerreiro, 1988-
core
Direct Cardiac Reprogramming: Progress and Promise. [PDF]
, 2018 The human adult heart lacks a robust endogenous repair mechanism to fully restore cardiac function after insult; thus, the ability to regenerate and repair the injured myocardium remains a top priority in treating heart failure.
Ardehali, Reza, Engel, James L
core +3 more sources
Examination into protein assembly within the cardiac thin filament: Why the troponin complex crosses over [PDF]
, 2023 Anthony Baldo +2 more
openalex +1 more source
NMR studies delineating spatial relationships within the cardiac troponin I-troponin C complex.
Journal of Biological Chemistry, 1994 NMR spectroscopy and selective isotope labeling of both recombinant cardiac troponin C (cTnC3) and a truncated cardiac troponin I (cTnI/NH2) lacking the N-terminal 32-amino acid cardiac-specific sequence have been used to probe protein-protein interactions central to muscle contraction.
G A, Krudy +5 more
openaire +2 more sources
Generating golden Syrian hamsters with conditional alleles via zygote microinjection of CRISPR/Cas9
Animal Models and Experimental Medicine, EarlyView.We established the first conditional knockout (cKO) model in the golden Syrian hamster by CRISPR/Cas9‐mediated genome editing. Cas9 protein, two sgRNAs, and a donor plasmid carrying loxP‐flanked exon 2 of the ApoF gene were microinjected into one‐cell embryos. The floxed allele was efficiently generated (up to 27%) and transmitted through the germline.
Wei Chen +16 more
wiley +1 more source
Age- and activity-related differences in the abundance of Myosin essential and regulatory light chains in human muscle [PDF]
, 2016 Traditional methods for phenotyping skeletal muscle (e.g., immunohistochemistry) are labor-intensive and ill-suited to multixplex analysis, i.e., assays must be performed in a series. Addressing these concerns represents a largely unmet research need but
Burniston, Jatin G. +5 more
core +4 more sources
Annals of Neurology, EarlyView.Objective We aimed to evaluate the clinical utility of serum neurofilament light chain (sNfL) and cardiac troponin T (cTnT) in amyotrophic lateral sclerosis (ALS) and assess whether their combination improves diagnostic accuracy. Methods We retrospectively analyzed 293 ALS patients, 85 neurodegenerative disease controls, and 29 healthy controls.
Paula Lindenborn +6 more
wiley +1 more source