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Interaction of troponin C and troponin C fragments with troponin I and the troponin I inhibitory peptide

Biochemistry, 1992
We have quantitated the interactions of two rabbit skeletal troponin C fragments with troponin I and the troponin I inhibitory peptide. The calcium binding properties of the fragments and the ability of the fragments to exert control in the regulated actomyosin ATPase assay have also been studied. The N- and C-terminal divalent metal binding domains of
R. S. Fredricksen, Charles A. Swenson
openaire   +3 more sources

Dual-Wavelength Ratiometric Electrochemiluminescence Immunosensor for Cardiac Troponin I Detection.

Analytical Chemistry, 2018
Ratiometric electrochemiluminescence (ECL) has attracted special focus in the biological analysis field, because it could eliminate the environmental interference and allow for precise measurement.
Jing Ye   +7 more
semanticscholar   +1 more source

The mobility of troponin C and troponin I in muscle

Journal of Molecular Recognition, 1997
In vertebrate skeletal muscle, contraction is initiated by the elevation of the intracellular Ca2+ concentration. The binding of Ca2+ to TnC induces a series of conformational changes which ultimately release the inhibition of the actomyosin ATPase activity by Tnl.
Kálmán Hideg   +2 more
openaire   +3 more sources

Troponin

The Journal of Biochemistry, 1968
1. A method for isolation of troponin from native tropomyosin was described. 2. Troponin in combination with tropomyosin restored the whole activity of native tropomyosin in sensitizing the interaction of myosin and actin to Ca ion. 3. Troponin was found to bind nearly 4 moles of Ca per 10 5 g, of which most were exchangeable.
Fumiko Ebashi   +2 more
openaire   +5 more sources

The binding sites of rabbit skeletal troponin-I on troponin-T

Canadian Journal of Biochemistry, 1980
Various fragments derived from rabbit skeletal muscle troponin-T (Tn-T) by chemical and (or) proteolytic cleavage were mixed with whole troponin-I (Tn-I) and applied to a Sephadex G-75 gel filtration column in order to determine the binding site of Tn-I on Tn-T. This site of interaction was found to span two distinct regions of Tn-T.
Joyce R. Pearlstone, Lawrence B. Smillie
openaire   +2 more sources

Defining the Region of Troponin-I that Binds to Troponin-C

Biochemistry, 1999
The kinetics and energetics of the binding of three troponin-I peptides, corresponding to regions 96-131 (TnI96-131), 96-139 (TnI96-139), and 96-148 (TnI96-148), to skeletal chicken troponin-C were investigated using multinuclear, multidimensional NMR spectroscopy.
Ryan T. McKay   +4 more
openaire   +3 more sources

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