Results 1 to 10 of about 14,174,741 (341)

Hydrodynamic properties of bovine cardiac troponin-I and troponin-T.

Journal of Biological Chemistry, 1983
Bovine cardiac troponin-I (TN-I) and troponin-T (TN-T) have been examined in solution using ultracentrifugation, gel filtration, and viscosity. A new method of purifying TN-T, employing hydroxylapatite chromatography in 6 M urea, is reported. Cardiac TN-T (Mr = 36,000) undergoes a reversible, concentration-dependent association in nondenaturing buffers,
David M. Byers, C.M. Kay
openalex   +4 more sources

Clinical Utility of Cardiac Troponin I and Cardiac Troponin T Measurements [PDF]

Acta Medica, 1997
The measurement of CK-MB remains the test of choice for confirmation or exclusion of AMI and probably will remain the test of choice for routine diagnosis in the near future.
Michaela Adamcová, Zdeněk Kokštein, Jaroslava Vávrová   +2 more
doaj   +3 more sources

Half-Life and Clearance of Cardiac Troponin I and Troponin T in Humans. [PDF]

Circulation
BACKGROUND: Cardiac troponin (cTn) is key in diagnosing myocardial infarction (MI). After MI, the clinically observed half-life of cTn has been reported to be 7 to 20 hours, but this estimate reflects the combined elimination and simultaneous release of cTn from cardiomyocytes.
Kristensen JH, Hasselbalch RB, Strandkjær N, Jørgensen N, Østergaard M, Møller-Sørensen PH, Nilsson JC, Afzal S, Kamstrup PR, Dahl M, Bor MV, Frikke-Schmidt R, Jørgensen NR, Rode L, Holmvang L, Kjærgaard J, Bang LE, Forman J, Dalhoff K, Jaffe AS, Thygesen K, Bundgaard H, Iversen KK.   +22 more
europepmc   +5 more sources

Dephosphorylation specificities of protein phosphatase for cardiac troponin I, troponin T, and sites within troponin T [PDF]

International Journal of Biological Sciences, 2006
Protein dephosphorylation by protein phosphatase 1 (PP1), acting in concert with protein kinase C (PKC) and protein kinase A (PKA), is a pivotal regulatory mechanism of protein phosphorylation.
Brian H Crawford, Robert L. Raynor, Nathan M. Jideama, A K M A Hussain   +3 more
doaj   +4 more sources

Variation in Troponin I Measurement and the Cardiovascular Management Approach Following Elevated Troponin I Among Critically Ill Patients With Sepsis

Critical Care Explorations, 2023
IMPORTANCE:. Troponin I is frequently elevated in sepsis, but optimal clinical approaches to diagnosis and management of troponin I during sepsis are unclear. OBJECTIVES:.
Michael A. Garcia, MD, Nicholas A. Bosch, MD, MSc, Ithan D. Peltan, MD, MSc, Allan J. Walkey, MD, MSc   +3 more
doaj   +1 more source

Myocardial Tissue Characterization in Patients with Hypertensive Crisis, Positive Troponin, and Unobstructed Coronary Arteries: A Cardiovascular Magnetic Resonance-Based Study

Diagnostics, 2023
Hypertensive crisis can present with cardiac troponin elevation and unobstructed coronary arteries. We used cardiac magnetic resonance (CMR) imaging to characterize the myocardial tissue in patients with hypertensive crisis, elevated cardiac troponin ...
Mohammed A. Talle, Anton F. Doubell, Pieter-Paul S. Robbertse, Sa’ad Lahri, Philip G. Herbst   +4 more
doaj   +1 more source

Renal Elimination of Troponin T and Troponin I [PDF]

Clinical Chemistry, 2003
Cardiovascular complications represent the predominant cause of death in patients in the terminal stage of renal failure. Increased concentrations of cardiac troponin T (cTnT) may be a valuable predictor of cardiac risk (1)(2). However, cardiac troponin I (cTnI), clinical symptoms, and electrocardiogram (ECG) indications may be absent in patients with ...
Andreas Lun, Pranav Sinha, Rolfdieter Krause, Claudia Altermann, Gernot Asmus, Rainer Möbes, Friedrich Priem, Berthold Hocher, Reinhard Ziebig, Hartmut Kern, Babette Lorenz   +10 more
openaire   +3 more sources

The Prognostic Significance of Troponin I and Troponin T [PDF]

Academic Emergency Medicine, 1998
Abstract. Objectives: To determine and compare the prognostic abilities of early, single‐sample measurements of cardiac troponin I (cTn‐I), cardiac troponin T (cTn‐T), creatine kinase‐MB (CK‐MB) among ED patients with possible myocardial ischemia. Methods: Prospective collection of clinical and serologic data using an identity‐unlinked technique from
Edward S. Bessman, Daniel W. Chan, Dai J. Li, Gabor D. Kelen, Jennifer L. Cox, Gary B. Green   +5 more
openaire   +3 more sources

Location of troponin I‐binding on troponin T sequence [PDF]

FEBS Letters, 1982
Interaction between troponin T and troponin I is considered as one of those necessary for the calI cium-regulatory mechanism in the thin filament of vertebrate striated muscles [ 1,2]. Studies using chymotryptic subfragments of troponin T showed that the affinity for troponin I is localized in the region of the C-terminal 101 residues, termed troponin ...
Masaru Tanokura, Iwao Ohtsuki
openaire   +3 more sources

Impact of genotype and phenotype on cardiac biomarkers in patients with transthyretin amyloidosis - Report from the Transthyretin Amyloidosis Outcome Survey (THAOS). [PDF]

PLoS ONE, 2017
AIM:Cardiac troponins and natriuretic peptides are established for risk stratification in light-chain amyloidosis. Data on cardiac biomarkers in transthyretin amyloidosis (ATTR) are lacking.
Arnt V Kristen, Mathew S Maurer, Claudio Rapezzi, Rajiv Mundayat, Ole B Suhr, Thibaud Damy, THAOS investigators   +6 more
doaj   +1 more source