Results 91 to 100 of about 12,260,572 (400)

Prediction of cardiovascular disease risk by cardiac biomarkers in 2 United Kingdom cohort studies: does utility depend on risk thresholds for treatment? [PDF]

, 2016
We tested the predictive ability of cardiac biomarkers N-terminal pro B-type natriuretic peptide (NT-proBNP), high-sensitivity troponin T, and midregional pro adrenomedullin for cardiovascular disease (CVD) events using the British Regional Heart Study ...
Hart, Carole, McConnachie, Alex, Murray, Heather, Papacosta, Olia, Preiss, David, Ramsay, Sheena, Sattar, Naveed, Upton, Mark, Wannamethee, Goya, Watt, Graham, Welsh, Paul, Whincup, Peter   +11 more
core   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

The correlation between high-sensitivity troponin-T and cell-free cardiac DNA in the blood of patients undergoing noncardiac, predominantly vascular surgery

Journal of International Medical Research
Objective To present a novel method that uses an epigenetic fingerprint to measure changes in plasma concentrations of cardiac-specific cell-free DNA (CS-cfDNA) as a marker of myocardial cell death.
Tural Alekberli, Braha Lea Ohana, Hai Zemmour, Rudy Khader, Ruth Shemer, Yuval Dor, Giora Landesberg   +6 more
doaj   +1 more source

Physical limits on computation by assemblies of allosteric proteins [PDF]

, 2008
Assemblies of allosteric proteins, nano-scale Brownian computers, are the principle information processing devices in biology. The troponin C-troponin I (TnC-TnI) complex, the Ca$^{2+}$-sensitive regulatory switch of the heart, is a paradigm for Brownian computation.
arxiv   +1 more source

High sensitivity troponins and conventional troponins at the bedside

International Journal of Critical Illness and Injury Science, 2014
The continuing advances in the biochemical research for the discovering an ideal biomarker for diagnosing myocardial injury have led to discovery cardiac Troponin, a biochemical gold standard for myocardial necrosis. Further with advances in the immunoassay techniques, the 99th percentile cutoff value of cardiac troponin required for the diagnosis of ...
Sanjeev Bhoi, Pankaj Verma, Sameer Vankar, Sagar Galwankar   +3 more
openaire   +3 more sources

On/off-switchable LSPR nano-immunoassay for troponin-T

Scientific Reports, 2017
Regeneration of immunosensors is a longstanding challenge. We have developed a re-usable troponin-T (TnT) immunoassay based on localised surface plasmon resonance (LSPR) at gold nanorods (GNR).
M. Ashaduzzaman, Swapneel R. Deshpande, N. A. Murugan, Yogendra Kumar, Mishra, Anthony P. F. Turner, A. Tiwari   +6 more
semanticscholar   +1 more source

Biologically‐Inspired Melt Electrowriting for the Generation of Highly Biomimetic Functional Myocardium

Advanced Functional Materials, EarlyView.
In this work, melt electrowriting is used to fabricate a 3D printed scaffold design that generates engineered cardiac tissues with in‐plane contraction, mimicking natural myocardium. It is shown that these tissues display advanced maturation and functionality.
Olalla Iglesias‐García, María Flandes‐Iparraguirre, Pilar Montero‐Calle, Ricardo M. Rosales, Asier Ullate‐Agote, Andrea Sánchez‐Bueno, Eduardo Larequi, Ilazki Anaut‐Lusar, Nicolás Laita, Aida Oliván‐Viguera, Elena Iglesias, Gloria Abizanda, Patxi San Martín‐Úriz, Paula Aguirre‐Ruiz, Xabier L. Aranguren, Manuel García de Yébenes, Juan José Gavira, Miguel Ángel Martínez, Estefanía Peña, Manuel Doblaré, Elena M. de‐Juan‐Pardo, Esther Pueyo, Felipe Prosper, Manuel M. Mazo Vega   +23 more
wiley   +1 more source

Proximity mapping of troponin T and troponin I in cardiac troponin using molecular dynamics simulations [PDF]

Biophysical Journal, 2009
The intersite distances from cTnT residues 240, 276, and 288 to cTnI N-terminal residues 5, 17, 27, 40, and to the cTnI C-terminal residues 131, 145, 152, 160, and 167 in reconstituted cTn were determined in the presence of Mg2+ and Mg2+ plus Ca2+ using FRET.
Wen-Ji Dong, Herbert C. Cheung, John M. Robinson, Jun Xing, Jayant James Jayasundar   +4 more
openaire   +2 more sources

Origin of Cardiac Troponin T Elevations in Chronic Kidney Disease.

Circulation, 2017
Plasma concentrations of cardiac troponins, the preferred biomarkers for the diagnosis of acute myocardial infarction, are often persistently elevated in patients with chronic kidney disease (CKD).
N. van der Linden, T. Cornelis, D. Kimenai, Lieke J. J. Klinkenberg, J. Hilderink, Sarah Lück, E. Litjens, F. Peeters, Alexander S. Streng, T. Breidthardt, L. V. van Loon, O. Bekers, J. Kooman, P. Westermark, C. Mueller, S. Meex   +15 more
semanticscholar   +1 more source

The side chain of glutamine 13 is the acyl-donor amino acid modified by type 2 transglutaminase in subunit T of the native rabbit skeletal muscle troponin complex. [PDF]

, 2013
Subunit T of the native muscle troponin complex is a recognised substrate of transglutaminase both in vitro and in situ with formation of isopeptide bonds.
B. Ura, C. Cervellati, C. Esposito, C. Iannone, C. M. Bergamini, C. Mischiati, M. Squerzanti, PUCCI, PIETRO, R. Casadio, S. Annunziata   +9 more
core   +1 more source