Results 1 to 10 of about 5,264,822 (290)
Bovine cardiac troponin subunits: binary complexes and reconstitution of whole troponin [PDF]
FEBS Letters, 1982 The reconstitution of bovine cardiac troponin from its subunits has been investigated using hydrodynamic techniques. Gel filtration (Sephacryl S‐300) and sedimentation velocity experiments indicate that troponin‐C and troponin‐I from a stable binary complex (1:1 mole ratio) with an apparent Stokes' radius of 36 Å (frictional ratio = 1.6).
Byers, David M., Kay, Cyril M.
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Distance distributions and anisotropy decays of troponin C and its complex with troponin I [PDF]
Biochemistry, 1991 We used frequency domain measurements of fluorescence resonance energy transfer to recover the distribution of distances between Met 25 and Cys 98 in rabbit skeletal troponin C. These residues were labeled with dansylaziridine as energy donor and 5-(iodoacetamido)eosin as acceptor and are located on the N- and C-terminal lobes of the two-domain protein,
H C, Cheung +6 more
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Effects of troponin T cardiomyopathy mutations on the calcium sensitivity of the regulated thin filament and the actomyosin cross-bridge kinetics of human β-cardiac myosin. [PDF]
PLoS ONE, 2013 Hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) lead to significant cardiovascular morbidity and mortality worldwide. Mutations in the genes encoding the sarcomere, the force-generating unit in the cardiomyocyte, cause familial forms ...
Ruth F Sommese +5 more
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Calcium-dependent Changes in the Flexibility of the Regulatory Domain of Troponin C in the Troponin Complex [PDF]
Journal of Biological Chemistry, 2005 With the recent advances in structure determination of the troponin complex, it becomes even more important to understand the dynamics of its components and how they are affected by the presence or absence of Ca(2+). We used NMR techniques to study the backbone dynamics of skeletal troponin C (TnC) in the complex.
Blumenschein, Tharin M. A. +4 more
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Animal Cells and SystemsThe troponin complex is a critical component of thin filaments and plays an essential role in the calcium-mediated regulation of contraction and relaxation in striated muscles, including both cardiac and skeletal muscle.
Dongju Han +3 more
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Calcium induced regulation of skeletal troponin--computational insights from molecular dynamics simulations. [PDF]
PLoS ONE, 2013 The interaction between calcium and the regulatory site(s) of striated muscle regulatory protein troponin switches on and off muscle contraction. In skeletal troponin binding of calcium to sites I and II of the TnC subunit results in a set of structural ...
Georgi Z Genchev +2 more
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American Heart Journal Plus, 2022 Objectives: In an all-comers cohort undergoing percutaneous coronary intervention (PCI), we aimed to assess prevalence of high bleeding risk (HBR) patients and impact of HBR and dual antiplatelet therapy (DAPT) on clinical events.
Nicole D. van Hemert +11 more
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Antibody ReportsABCD_RB932, ABCD_RB933, ABCD-RB934, ABCD_RB935, ABCD_RB936 and ABCD_RB937 antibodies were generated against a peptide corresponding to amino acids 56-120 of the human cardiac troponin T isoform 6. All the discovered antibodies were able to recognize the
Bernardo Bollen Pinto +4 more
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Modeling Human Cardiac Thin Filament Structures
Frontiers in Physiology, 2022 Striated muscle contraction is regulated in a calcium-dependent manner through dynamic motions of the tropomyosin/troponin polymer, a multicomponent complex wrapped around actin-containing thin filaments.
Michael J. Rynkiewicz +2 more
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Clinical Biochemistry of Serum Troponin
DiagnosticsAccurate measurement and interpretation of serum levels of troponin (Tn) is a central part of the clinical workup of a patient presenting with chest pain suspicious for acute coronary syndrome (ACS).
Ilhan Gokhan +8 more
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