Troponin Variants as Markers of Skeletal Muscle Health and Diseases
Frontiers in Physiology, 2021 Ca2+-regulated contractility is a key determinant of the quality of muscles. The sarcomeric myofilament proteins are essential players in the contraction of striated muscles.
Monica Rasmussen +2 more
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Phosphorylation of the ‘37000 component’ of the troponin complex (troponin-T) [PDF]
Biochemical Journal, 1973 Most of the phosphorus present in the troponin complex, which on average contains 1 mol of P/80000g, is associated with the ‘37000 component’ (0.6mol of P/mol). The inhibitory protein and particularly the ‘37000 component’, but not the calcium-binding protein, were phosphorylated when incubated with phosphorylase b kinase and [γ-32P]ATP.
S V, Perry, H A, Cole
openaire +2 more sources
Disease-related cardiac troponins alter thin filament Ca2+ association and dissociation rates. [PDF]
PLoS ONE, 2012 The contractile response of the heart can be altered by disease-related protein modifications to numerous contractile proteins. By utilizing an IAANS labeled fluorescent troponin C, [Formula: see text], we examined the effects of ten disease-related ...
Bin Liu +4 more
doaj +1 more source
Tropomyosin–troponin complex in inherited cardiomyopathies
Heart RhythmA S Amin, Christian Krijger
exaly +3 more sources
Hypertrophic Cardiomyopathy Mutations of Troponin Reveal Details of Striated Muscle Regulation
Frontiers in Physiology, 2022 Striated muscle contraction is inhibited by the actin associated proteins tropomyosin, troponin T, troponin I and troponin C. Binding of Ca2+ to troponin C relieves this inhibition by changing contacts among the regulatory components and ultimately ...
J. M. Chalovich, L. Zhu, D. Johnson
doaj +1 more source
Protein kinase C phosphomimetics alter thin filament Ca2+ binding properties. [PDF]
PLoS ONE, 2014 Adrenergic stimulation modulates cardiac function by altering the phosphorylation status of several cardiac proteins. The Troponin complex, which is the Ca(2+) sensor for cardiac contraction, is a hot spot for adrenergic phosphorylation. While the effect
Bin Liu +3 more
doaj +1 more source
Frontiers in Physiology, 2022 Small molecule cardiac troponin activators could potentially enhance cardiac muscle contraction in the treatment of systolic heart failure. We designed a small molecule, RPI-194, to bind cardiac/slow skeletal muscle troponin (Cardiac muscle and slow ...
Zabed Mahmud +13 more
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Monoclonal Antibodies as Probes to Study Ligand-Induced Conformations of Troponin Subunits
Frontiers in Physiology, 2022 Striated muscle contraction and relaxation is regulated by Ca2+ at the myofilament level via conformational modulations of the troponin complex. To understand the structure–function relationship of troponin in normal muscle and in myopathies, it is ...
Monica Rasmussen +2 more
doaj +1 more source
Scientific Reports, 2023 The large unmet demand for new heart failure therapeutics is widely acknowledged. Over the last decades the contractile myofilaments themselves have emerged as an attractive target for the development of new therapeutics for both systolic and diastolic ...
Priyanka Parijat +6 more
doaj +1 more source
Cardiac troponin I but not cardiac troponin T adheres to polysulfone dialyser membranes in an in vitro haemodialysis model: explanation for lower serum cTnI concentrations following dialysis. [PDF]
, 2014 BACKGROUND: Elevated serum cardiac troponin T (cTnT) and I (cTnI) can occur in patients with chronic kidney disease. Differences in cTn concentrations between cTnT and cTnI have been reported but the mechanism of such discrepancy has not been ...
Collinson, PO +5 more
core +1 more source