Interaction of bepridil with the cardiac troponin C/troponin I complex [PDF]
FEBS Letters, 2001 We have investigated the binding of bepridil to calcium‐saturated cardiac troponin C in a cardiac troponin C/troponin I complex. Nuclear magnetic resonance spectroscopy and [15N,2H]cardiac troponin C permitted the mapping of bepridil‐induced amide proton chemical shifts. A single bepridil‐binding site in the regulatory domain was found with an affinity
Natosha Finley, P R Rosevear
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Order-Disorder Transitions in the Cardiac Troponin Complex. [PDF]
J Mol Biol, 2016 The troponin complex is a molecular switch that ties shifting intracellular calcium concentration to association and dissociation of actin and myosin, effectively allowing excitation-contraction coupling in striated muscle. Although there is a long history of muscle biophysics and structural biology, many of the mechanistic details that enable troponin'
Metskas LA, Rhoades E.
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Focus on cardiac troponin complex: From gene expression to cardiomyopathy [PDF]
Genes and DiseasesThe cardiac troponin complex (cTn) is a regulatory component of sarcomere. cTn consists of three subunits: cardiac troponin C (cTnC), which confers Ca2+ sensitivity to muscle; cTnI, which inhibits the interaction of cross-bridge of myosin with thin ...
Rosetta Ragusa, Chiara Caselli
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Influence of Anticoagulants on the Dissociation of Cardiac Troponin Complex in Blood Samples. [PDF]
Int J Mol SciImmunodetection of cardiac isoforms of troponin I (cTnI) and troponin T (cTnT) in blood samples is widely used for the diagnosis of acute myocardial infarction.
Riabkova NS +8 more
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A case report of falsely elevated high-sensitivity cardiac troponin I due to macro-troponin I [PDF]
Practical Laboratory MedicineThis article reports a clinical case of falsely and significantly elevated high-sensitivity cardiac troponin I (hs-cTnI) levels caused by “Macro-Troponin I''.
Yinfu Sun +5 more
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Phosphorylation of troponin and the effects of interactions between the components of the complex [PDF]
Biochemical Journal, 1974 1. The troponin complex from skeletal muscle contains approximately 1 mol of phosphate/80000g of complex, covalently bound to the troponin T component. 2. On prolonged incubation of the troponin complex or troponin T with phosphorylase kinase the phosphate content of troponin T was increased to approx. 3mol/mol. 3. On prolonged incubation of troponin I
S V, Perry, H A, Cole
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Development of a sensitive immunosensor for the detection of cardiac Troponin T in cardiovascular disease [PDF]
, 2014 Cardiovascular disease (CVD) is currently globally the biggest cause of mortality, with rising figures, especially now in the developing world. Early and accurate diagnosis of CVD, (especially acute myocardial infarction (AMI) is important in being able ...
Pawula, Maria
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Desensitization of the Cardiac Troponin Complex by TnI Phosphorylation and Epigallocatechin-3-Gallate [PDF]
ACS OmegaHelene Tigro +5 more
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Recombinant nanobodies detecting the human cardiac troponin proteins by ELISA
Antibody Reports, 2023 We tested the capacity of antibodies RB733, RB734, RB766, RB767, RB768, RB769, RB770, RB771, RB772 and RB773 to recognize by ELISA three different molecular forms of the human cardiac troponin T isoform 6 (cTnT): an N-terminal peptide (Nter-cTnT), the ...
Bernardo Bollen Pinto +5 more
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An in silico analysis of troponin I mutations in hypertrophic cardiomyopathy of Indian origin. [PDF]
PLoS ONE, 2013 Hypertrophic Cardiomyopathy (HCM) is an autosomal dominant disorder of the myocardium which is hypertrophied resulting in arrhythmias and heart failure leading to sudden cardiac death (SCD).
Gayatri Ramachandran +6 more
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