Results 41 to 50 of about 5,264,822 (290)

Genetically Encoded Calcium Indicators Based on Troponin C and Fluorescent Proteins [PDF]

, 2005
Genetically encoded calcium probes allow the visualization and quantification of intracellular calcium dynamics with great specificity and sensitivity.
Heim, Nicola
core   +1 more source

The calcium‐induced switch in the troponin complex probed by fluorescent mutants of troponin I [PDF]

European Journal of Biochemistry, 2003
The Ca2+‐induced transition in the troponin complex (Tn) regulates vertebrate striated muscle contraction. Tn was reconstituted with recombinant forms of troponin I (TnI) containing a single intrinsic 5‐hydroxytryptophan (5HW). Fluorescence analysis of these mutants of TnI demonstrate that the regions in TnI that respond to Ca2+ binding to the ...
Deodoro C S G, Oliveira, Fernando C, Reinach   +1 more
openaire   +2 more sources

Computational Studies of Cardiac and Skeletal Troponin

Frontiers in Molecular Biosciences, 2019
Troponin is a key regulatory protein in muscle contraction, consisting of three subunits troponin C (TnC), troponin I (TnI), and troponin T (TnT). Calcium association to TnC initiates contraction by causing a series of dynamic and conformational changes ...
Jacob D. Bowman, Steffen Lindert
doaj   +1 more source

High-sensitivity troponin I concentrations are a marker of an advanced hypertrophic response and adverse outcomes in patients with aortic stenosis [PDF]

, 2014
AIMS: High-sensitivity cardiac troponin I (cTnI) assays hold promise in detecting the transition from hypertrophy to heart failure in aortic stenosis.
Lang, Chim C., Langrish, Jeremy P, Langrish, Jeremy P., Newby, David E., Shah, Anoop, Dweck, Marc R, Alam, Shirjel, Mills, Nicholas L; id_orcid, McAllister, David A, Hunter, Amanda L., Cowell, S. Joanna, Boon, Nicholas A, Shah, Anoop S.V., Strachan, Fiona E, McAllister, David A., Maria Choy, Anna; id_orcid, Strachan, Fiona E., Boon, Nicholas A., Mills, Nicholas L., Dweck, Marc R., Shah, Anoop S. V., Newby, David E, Lang, Chim C.; id_orcid, Chin, Calvin W.L., Chin, Calvin W L, Chin, Calvin W. L., Joanna Cowell, S, Maria Choy, Anna, Walker, Simon, Lang, Chim C, Hunter, Amanda L   +30 more
core   +1 more source

Troponin release following endurance exercise: is inflammation the cause? a cardiovascular magnetic resonance study [PDF]

, 2010
Background: The aetiology and clinical significance of troponin release following endurance exercise is unclear but may be due to transient myocardial inflammation.
Wong Joyce, Whyte, G, Prasad, SK, Whyte, Greg, Smith Gillian, Annette Dahl, Smith, Gillian, Wage, R, Godfrey, R, Wilson, M, Gillian Smith, Francisco D Alpendurada, Sharma Sanjay, Prasad, Sanjay, O'Hanlon Rory, George Keith, Wage, Riccardo, Pennell, DJ, Pennell Dudley J, Roughton, Michael, Prasad Sanjay K, Roughton Michael, George, Keith, Rory O'Hanlon, Alpendurada Francisco D, Mat Wilson, Pennell, Dudley, Roughton, M, Sharma, S, Dahl, Annette, Greg Whyte, Sanjay K Prasad, Wilson Mat, Dave Oxborough, Alpendurada, Francisco, O'Hanlon, Rory, Keith George, Oxborough, Dave, Godfrey Richard, Wage Riccardo, Wong, Joyce, Dahl, A, Whyte Greg, Wilson, Mat, Smith, G, Joyce Wong, Richard Godfrey, Sanjay Sharma, Wong, J, Alpendurada, FD, Oxborough, D, Oxborough Dave, O'Hanlon, R, Dudley J Pennell, Riccardo Wage, Godfrey, Richard, Sharma, Sanjay, Michael Roughton, Dahl Annette, George, K   +59 more
core   +1 more source

Cardiac troponins in intensive care [PDF]

, 2005
The cardiac troponins are integral components of the myofibrillary apparatus and they regulate muscle contraction. The measurement of cardiac troponins has replaced other biomarkers for the specific detection of myocardial necrosis and for the diagnosis ...
Collinson, P.O., Gaze, D.C., Collinson, P, Gaze, D   +3 more
core   +1 more source

Troponin T and Neurofilament Light Chain Levels as Complementary Biomarkers of Disease Accumulation and Aggressiveness in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a clinically heterogeneous neurodegenerative disease requiring reliable biomarkers to improve patient stratification and trial design. While serum neurofilament light chain (sNfL) reflects neuroaxonal stress and disease aggressiveness, troponin T (TnT) may capture complementary aspects of ...
Julia Sellin, Sofia Waldorf, Janina von der Gablentz, Torsten Grehl, Huelya Nazlican, Thomas Meyer, Julian Grosskreutz, Patrick Weydt, Sarah Bernsen   +8 more
wiley   +1 more source

The Lupus Damage Index Revision Program: Results From the Item Generation and Reduction Phases

Arthritis Care &Research, EarlyView.
Objective A data‐driven and expert/patient consensus‐based project to develop a revised Systemic Lupus International Collaborating Clinics (SLICC)/American College of Rheumatology (ACR) Damage Index (SDI) is under way supported by SLICC, ACR, and the Lupus Foundation of America. Our objective is to report the item generation and reduction phase results
Burak Kundakci, Megan R. W. Barber, Ann E. Clarke, Sindhu R. Johnson, Anselm Mak, Hermine I. Brunner, Murat Inanc, Rosalind Ramsey‐Goldman, Guillermo Ruiz‐Irastorza, Ellen M. Ginzler, John G. Hanly, Alexandra Legge, Cynthia Aranow, Laurent Arnaud, Nathalie Costedoat‐Chalumeau, Dafna D. Gladman, Søren Jacobsen, Michelle Petri, Clovis A. Silva, Évelyne Vinet, Alexandre E. Voskuyl, SDI Revision Literature Review Groups, SDI Revision Delphi Panel, SDI Revision Item Reduction Committee, SDI Revision Clinical Domain Groups, Ian N. Bruce   +25 more
wiley   +1 more source

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

The Solution Structure of a Cardiac Troponin C−Troponin I−Troponin T Complex Shows a Somewhat Compact Troponin C Interacting with an Extended Troponin I−Troponin T Component [PDF]

Biochemistry, 2002
We have investigated the structure of the cTnC-cTnI-cTnT(198-298) calcium-saturated, ternary cardiac troponin complex by small-angle scattering with contrast variation. Shape restoration was also applied to the scattering information resulting from the deuterated cTnC subunit, the unlabeled cTnI-cTnT(198-298) subunits, and the entire complex.
William T, Heller, Ekram, Abusamhadneh, Natosha, Finley, Paul R, Rosevear, Jill, Trewhella   +4 more
openaire   +2 more sources