Results 61 to 70 of about 5,264,822 (290)

DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury

Advanced Science, EarlyView.
This study identifies a potential therapeutic approach for sepsis‐associated acute kidney injury (SA‐AKI). We found that during SA‐AKI, reduced expression of DDX3x in renal tubular epithelial cells mediates histone delactylation, which in turn upregulates NINJ1 transcription and triggers tubular cell death. Conversely, Odetiglucan confers protection by
Hongyu Liang, Jihong Jiang, Huanxin Yin, Chunyan Liu, Hongjun Huang, Yan Luo, Minmin Zhu, Qiuyun Wang   +7 more
wiley   +1 more source

Nucleoside‐Modified mRNA Encoding Alpha‐Galactosidase A Ameliorates Fabry Disease Phenotypes in Human IPSC‐Derived Cardiomyocytes

Advanced Science, EarlyView.
Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem, Lea Oehlsen, Sedef Ersoy, Jia Li Ye, Natalie Weber, Elisa Mohr, Wilson Agyapong, Junqing Liu, Maximilian Fuchs, Ke Xiao, Christopher Jahn, Reto Eggenschwiler, Tobias Cantz, Julia Beimdiek, Falk F. R. Buettner, Theresia Kraft, Jan Hegermann, Ivonne J. Knorr, Lisa Ernst, Linda Feldbrügge, Resa Puffert, Kevin Schmidt, Christian Bär, Jeannine Hoepfner, Thomas Thum   +24 more
wiley   +1 more source

Coarse-Grained Modeling of Peptide Docking Associated with Large Conformation Transitions of the Binding Protein: Troponin I Fragment–Troponin C System

Molecules, 2015
Most of the current docking procedures are focused on fine conformational adjustments of assembled complexes and fail to reproduce large-scale protein motion. In this paper, we test a new modeling approach developed to address this problem.
Jacek Wabik, Mateusz Kurcinski, Andrzej Kolinski   +2 more
doaj   +1 more source

Interaction of aldolase with the troponin–tropomyosin complex of bovine muscle [PDF]

Biochemical Journal, 1974
Ultracentrifugal studies of mixtures of aldolase and the troponin–tropomyosin complex from bovine muscle showed the existence of a labile interaction between these two myofibrillar constituents in imidazole buffers, pH6.8, I 0.02–0.10 (mol/l), and the suppression of the reaction by fructose 1,6-diphosphate.
Clarke F.M., Masters C.J., Winzor D.J.
openaire   +4 more sources

CDK4/MERCs/PINK1 Axis Drives PFOA/HFPO‐TA‐Induced Cardiac Senescence via Mitophagy Defect and cGAS‐STING Activation: In Vitro Amelioration by Cycloastragenol

Advanced Science, EarlyView.
The present study demonstrated that PFOA and HFPO‐TA exposure suppressed CDK4, disrupted MERCs and impaired PINK1/Parkin‐mediated mitophagy, thereby accelerating cardiac senescence, whereas CAG effectively reversed these pathological changes in vitro. Our findings identify CDK4 as a critical regulator bridging mitophagy defects and cardiac senescence ...
Nuo‐Wa Li, Jun‐Ze Jiang, Ying‐Ying Liu, Tian‐Tian Zhang, Kanwar Kumar Malhi, Xin Yao, Jin‐Long Li   +6 more
wiley   +1 more source

Hypertrophic Cardiomyopathy Cardiac Troponin C Mutations Differentially Affect Slow Skeletal and Cardiac Muscle Regulation

Frontiers in Physiology, 2017
Mutations in TNNC1—the gene encoding cardiac troponin C (cTnC)—that have been associated with hypertrophic cardiomyopathy (HCM) and cardiac dysfunction may also affect Ca2+-regulation and function of slow skeletal muscle since the same gene is expressed ...
Jose R. Pinto, Tiago Veltri, Maicon Landim-Vieira, Michelle S. Parvatiyar, David Gonzalez-Martinez, Karissa M. Dieseldorff Jones, Clara A. Michell, David Dweck, Andrew P. Landstrom, P. Bryant Chase   +9 more
doaj   +1 more source

Toll-Like Receptor-Mediated Cardiac Injury during Experimental Sepsis

Mediators of Inflammation, 2020
Sepsis is associated with global cardiac dysfunction and with high mortality rate. The development of septic cardiomyopathy is due to complex interactions of damage-associated molecular patters, cytokines, and complement activation products.
Ina Lackner, Birte Weber, Shinjini Chakraborty, Sonja Braumüller, Markus Huber-Lang, Florian Gebhard, Miriam Kalbitz   +6 more
doaj   +1 more source

PKCα-specific phosphorylation of the troponin complex in human myocardium: a functional and proteomics analysis. [PDF]

PLoS ONE, 2013
AIMS:Protein kinase Cα (PKCα) is one of the predominant PKC isoforms that phosphorylate cardiac troponin. PKCα is implicated in heart failure and serves as a potential therapeutic target, however, the exact consequences for contractile function in human ...
Viola Kooij, Pingbo Zhang, Sander R Piersma, Vasco Sequeira, Nicky M Boontje, Paul J M Wijnker, Connie R Jiménez, Kornelia E Jaquet, Cris dos Remedios, Anne M Murphy, Jennifer E Van Eyk, Jolanda van der Velden, Ger Jm Stienen   +12 more
doaj   +1 more source

Standardization of troponin I measurements : an update

, 2008
Standardization of cardiac troponin I (cTnI) measurement is important because of the central role for diagnosis of myocardial infarction. In blood, cTnI is present as a heterogeneous mixture of different molecular species.
M. Panteghini, R. H. Christenson, A. Katrukha, J. R. Tate for the IFCC Working Group on Standardization of Troponin I., L. Wang, D. M. Bunk, R. A. Porter, H. Schimmel   +7 more
core   +1 more source

Cryptographic Puzzles and Complex Systems

, 2021
A puzzle lies behind password authentication (PA) and blockchain proof of work (PoW). A cryptographic hash function is commonly used to implement them. The potential problem with secure hash functions is their complexity and rigidity.
Vuckovac, Rade
core   +1 more source