Results 81 to 90 of about 5,264,822 (290)

Do consumers and healthcare professionals report the same adverse event differently? A paired analysis of duplicate vaccine safety reports in Norway

British Journal of Clinical Pharmacology, EarlyView.
Aim This study aimed to compare how Norwegian healthcare professionals (HCPs) and consumers reported the same adverse event (AE) following immunization with vaccines against COVID‐19 during the COVID‐19 pandemic. Specifically, we aimed to compare the extent to which HCPs and consumers reported information relevant for assessing the causal relationship ...
Tommy Emil Dzus, Johaina Sarrage, Hilde Samdal, François Montastruc, Elena Rocca   +4 more
wiley   +1 more source

Structure of the troponin complex. Implications of photocross-linking of troponin I to troponin C thiol mutants.

Journal of Biological Chemistry, 1994
Ca2+ regulation of vertebrate-striated muscle contraction is initiated by conformational changes in the Ca(2+)-binding protein troponin C (TnC) and subsequent changes in the interaction of TnC with the inhibitory protein TnI. We have constructed mutants of rabbit skeletal muscle TnC in which natural Cys-98 was replaced by Leu, and a single Cys residue ...
T, Kobayashi, T, Tao, J, Gergely, J H, Collins   +3 more
openaire   +2 more sources

Standardisation of cardiac troponin I measurement: past and present

, 2010
The laboratory measurement of cardiac troponin (cTn) concentration is a critical tool in the diagnosis of acute myocardial infarction (MI). Current cTnI assays produce different absolute troponin numbers and use different clinical cut-off values; hence ...
R. H. Christenson, M. Panteghini, A. Katrukha, L. Wang, Alexei Katrukha, Jillian R. Tate, David M. Bunk, James E. Noble, D. M. Bunk, for the IFCC Working Group on Standardization of Troponin I., Lili Wang, Robert A. Porter, J. R. Tate, Robert H. Christenson, Mauro Panteghini, J. E. Noble, R. A. Porter, H. Schimmel, Heinz Schimmel   +18 more
core   +1 more source

Machine Learning Models of Phase Contrast Images Predict Efficiency of Human Pluripotent Stem Cell Differentiation to Cardiomyocytes

Biotechnology and Bioengineering, EarlyView.
Human pluripotent stem cells were differentiated to cTnT+ cardiomyocytes and imaged throughout the process using phase contrast. We predicted differentiation efficiency (cTnT+ area) from phase contrast and compared model performance with a live‐cell cTnT‐GFP reporter.
Austin K. Feeney, Yaniv Ovadia, Aaron D. Simmons, Christian Elabd, Claire J. Peplinski, Frank Li, Sean P. Palecek   +6 more
wiley   +1 more source

Multiple molecular forms of circulating cardiac troponin: Analytical and clinical significance

, 2008
Cardiac troponin T (cTnT) and I (cTnI) are highly specific and sensitive biomarkers of myocardial cell damage and are now accepted as the ‘gold standard’ diagnostic test for acute coronary syndrome and supersede the classical muscle enzyme biomarkers ...
Collinson, P.O., Gaze, D.C.
core   +1 more source

Metal nanostructure‐coupled label‐free localized surface plasmon resonance biosensors for rapid and sensitive disease diagnosis

BMEMat, EarlyView.
LSPR biosensing enables rapid, sensitive, and low‐sample‐volume detection of biomarkers, with broad applications in diagnosing cancer, infectious, and chronic diseases. Advances in nanostructure design, micro/nanofabrication, and microfluidic integration have expanded the potential of LSPR sensors in biomedical diagnostics.
Zhaoxin Geng, Yunfei Sha, Jiongyan Yang, Hongru Yang, Xiao Liang   +4 more
wiley   +1 more source

The impact of electroconvulsive therapy on the spatial QRS-T angle and cardiac troponin T concentration in psychiatric patients.

PLoS ONE, 2019
BackgroundElectroconvulsive therapy (ECT) is an effective treatment method used in psychiatry; however, its cardiac safety has not been clearly demonstrated.
Michał Próchnicki, Grzegorz Rudzki, Michał Dzikowski, Andrzej Jaroszyński, Hanna Karakula-Juchnowicz   +4 more
doaj   +1 more source

WT ANS-labeled troponin complex properties.

, 2013
Ca2+ sensitivity of WT-ANS troponin complex and thin filament with different amounts of human β-cardiac S1 at 23°C. Each curve is the average of at least three individual curves, and error bars represent SEM.
Suman Nag (225662), Susan M. Miller (499139), James A. Spudich (67495), Kathleen M. Ruppel (499140), Ruth F. Sommese (499138), Shirley Sutton (56716)   +5 more
core   +1 more source

Mitochondria‐endoplasmic reticulum organelle glue as maturation promoter for origination/dimensional dual‐cross cardiomyocytes

BMEMat, EarlyView.
Mitochondria‐endoplasmic reticulum contact sites (MERCS) are areas where the mitochondria and endoplasmic reticulum closely interact. In this study, we utilize synthetic organelle glues to artificially engineer MERCS for regulating cardiomyocyte development, through which the immature and chemo‐plasticity issues of undifferentiated cells are addressed.
Wei Tang, Hao Sun, Chenqi Duan, Jiajia Chang, Yuxing Wang, Ming Zhao, Huiyue Zhao, Shan Lu, Yang Yang, Da Huo   +9 more
wiley   +1 more source

Hypertrophic and Dilated Cardiomyopathy-Associated Troponin T Mutations R130C and ΔK210 Oppositely Affect Length-Dependent Calcium Sensitivity of Force Generation

Frontiers in Physiology, 2020
Length-dependent activation of calcium-dependent myocardial force generation provides the basis for the Frank-Starling mechanism. To directly compare the effects of mutations associated with hypertrophic cardiomyopathy and dilated cardiomyopathy, the ...
Marcel Groen, Alfredo Jesus López-Dávila, Stefan Zittrich, Gabriele Pfitzer, Robert Stehle   +4 more
doaj   +1 more source