Results 31 to 40 of about 5,264,822 (290)

Association of Serum Osteoprotegerin Level With Myocardial Injury and Cardiovascular Calcification in Chronic Kidney Disease Patients

Frontiers in Medicine, 2022
BackgroundChronic kidney disease has emerged as a significant independent risk factor for cardiovascular disease. Cardiovascular calcification is an active process involving a complex interaction of inducers and inhibitors.
Kamal M. Okasha, Mohamed Hussein Aboufreikha, Waleed Elrefaey, Medhat M. Ashmawy, Heba Mourad, Mohamed A. Elsebaey, Mohammed H. Elnaggar, Raghda Gabr Mashaal, Sama Metwally, Shaimaa Samir Amin Mashal, Neveen A. Shalaby, Shireen Ali Elhoseny, Amr Alkassas, Mohammed Elbarbary, Osama Shoeib, Dina A. Ali, Nivin Baiomy, Sherein M. Alnabawy   +17 more
doaj   +1 more source

The calcium sensitizer drug MCI-154 binds the structural C-terminal domain of cardiac troponin C

Biochemistry and Biophysics Reports, 2018
The compound MCI-154 was previously shown to increase the calcium sensitivity of cardiac muscle contraction. Using solution NMR spectroscopy, we demonstrate that MCI-154 interacts with the calcium-sensing subunit of the cardiac troponin complex, cardiac ...
Monica X. Li, Shorena Gelozia, Gaddafi I. Danmaliki, Yurong Wen, Philip B. Liu, M. Joanne Lemieux, Frederick G. West, Brian D. Sykes, Peter M. Hwang   +8 more
doaj   +1 more source

Molecular dynamics simulations of the cardiac troponin complex performed with FRET distances as restraints. [PDF]

PLoS ONE, 2014
Cardiac troponin (cTn) is the Ca(2+)-sensitive molecular switch that controls cardiac muscle activation and relaxation. However, the molecular detail of the switching mechanism and how the Ca(2+) signal received at cardiac troponin C (cTnC) is ...
Jayant James Jayasundar, Jun Xing, John M Robinson, Herbert C Cheung, Wen-Ji Dong   +4 more
doaj   +1 more source

Ca2+-induced PRE-NMR changes in the troponin complex reveal the possessive nature of the cardiac isoform for its regulatory switch. [PDF]

PLoS ONE, 2014
The interaction between myosin and actin in cardiac muscle, modulated by the calcium (Ca2+) sensor Troponin complex (Tn), is a complex process which is yet to be fully resolved at the molecular level. Our understanding of how the binding of Ca2+ triggers
Nicole M Cordina, Chu K Liew, Phani R Potluri, Paul M Curmi, Piotr G Fajer, Timothy M Logan, Joel P Mackay, Louise J Brown   +7 more
doaj   +1 more source

Development of a specific troponin I detection system with enhanced immune sensitivity using a single monoclonal antibody [PDF]

Royal Society Open Science, 2020
Using an immunoassay in combination with surface plasmon fluorescence spectroscopy (SPFS), we report the rapid detection of troponin I, a valuable biomarker for diagnosis of myocardial infarction.
Anıl Bozdogan, Reham F. El-Kased, Vanessa Jungbluth, Wolfgang Knoll, Jakub Dostalek, Amal Kasry   +5 more
doaj   +1 more source

NMR analysis of cardiac troponin C‐troponin I complexes: effects of phosphorylation [PDF]

FEBS Letters, 1999
Phosphorylation of the cardiac specific amino‐terminus of troponin I has been demonstrated to reduce the Ca2+ affinity of the cardiac troponin C regulatory site. Recombinant N‐terminal cardiac troponin I proteins, cardiac troponin I(33–80), cardiac troponin I(1–80), cardiac troponin I(1–80)DD and cardiac troponin I(1–80)pp, phosphorylated by protein ...
Finley, Natosha, Abbott, M.Bret, Abusamhadneh, Ekram, Gaponenko, Vadim, Dong, Wen-ji, Gasmi-Seabrook, G, Howarth, Jack W, Rance, Mark, Solaro, R.John, Cheung, Herbert C, Rosevear, Paul R   +10 more
openaire   +3 more sources

Comparison of ARCHITECT chemiluminiscent microparticle immunoassay for determination of Troponin I in serum with AXYM MEIA technology

Journal of Health Sciences, 2011
Introduction: The aim of this study was determination of troponin I at serum using Architect (Abbott) and AxSYM System (Abbott). Troponin is regulatory subunit of the troponin complex associate with actin filament within muscle cells and it is a marker ...
Nafija Serdarević
doaj   +1 more source

Dynamics of a Troponin Chimera Reproduce the Effects of Calcium on the Troponin Complex [PDF]

Biophysical Journal, 2012
In striated muscle, contraction is regulated in a Ca2+-dependent manner by the three subunits of the troponin complex. Troponin I (TnI) inhibits actomyosin ATPase in the absence of calcium; Ca2+ binding to troponin C (TnC) causes conformational changes that alter the interaction between TnI and TnC, removing the inhibition. These conformational changes
Julien, Olivier, Allen, Claire N., Mercier, Pascal, Ramos, Carlos H.I., Blumenschein, Tharin M.A., Sykes, Brian D.   +5 more
openaire   +1 more source

A Case Series of Disproportionate Elevations of Cardiac Troponin and Macrotroponin in Fabry Disease [PDF]

Journal of Inborn Errors of Metabolism and Screening
Fabry disease is a rare X-linked lysosomal storage disorder that causes progressive cellular accumulation of glycosphingolipids, leading to various end-organ manifestations such as chronic kidney disease and cardiomyopathy.
Yvonne Moussa, Cankayan Suthaharen, Kerry Devine, Michel Tchan, Rebecca Kozor, Yusof Rahman   +5 more
doaj   +1 more source

Anti–Cardiac Troponin Autoantibodies Are Specific to the Conformational Epitopes Formed by Cardiac Troponin I and Troponin T in the Ternary Troponin Complex [PDF]

Clinical Chemistry, 2017
Abstract BACKGROUND Autoantibodies to cardiac troponins (TnAAbs) could negatively affect cardiac troponin I (cTnI) measurements by TnAAbs-sensitive immunoassays. We investigated the epitope specificity of TnAAbs and its influence on cTnI immunodetection in patients with acute myocardial infarction ...
Alexandra V, Vylegzhanina, Alexander E, Kogan, Ivan A, Katrukha, Olga V, Antipova, Andrey N, Kara, Anastasia V, Bereznikova, Ekaterina V, Koshkina, Alexey G, Katrukha   +7 more
openaire   +2 more sources