The side chain of glutamine 13 is the acyl-donor amino acid modified by type 2 transglutaminase in subunit T of the native rabbit skeletal muscle troponin complex. [PDF]
Subunit T of the native muscle troponin complex is a recognised substrate of transglutaminase both in vitro and in situ with formation of isopeptide bonds.
B. Ura +9 more
core +1 more source
Cardiac Specific Gene Expression Changes in Long Term Culture of Murine Mesenchymal Stem Cells [PDF]
Murine MSCs are a readily available source of adult stem cells enabling extensive in vitro study of this cell population. MSCs have been described as multipotent, and have been proven capable of differentiation into several connective tissue types ...
Argyle, D.J. +6 more
core +2 more sources
Dynamics and calcium association to the N-terminal regulatory domain of human cardiac troponin C: a multiscale computational study. [PDF]
Troponin C (TnC) is an important regulatory molecule in cardiomyocytes. Calcium binding to site II in TnC initiates a series of molecular events that result in muscle contraction.
Huber, Gary +4 more
core +2 more sources
Metformin for non-diabetic patients with coronary heart disease (the CAMERA study): a randomised controlled trial [PDF]
<br>Background: Metformin reduces cardiovascular risk in patients with type 2 diabetes seemingly independent of lowering blood glucose concentration. We assessed the cardiovascular effects of metformin in individuals without type 2 diabetes.</br&
Eddy +33 more
core +5 more sources
Cardiac markers in children and adolescents at the onset of type 1 diabetes mellitus.
BackgroundThe incidence of type 1 diabetes mellitus (T1DM) in children and adolescents is rising, and both micro- and macrovascular complications pose significant health risks.
Sara Musterer +10 more
doaj +1 more source
Impact of soluble fms-like tyrosine kinase-1 and placental growth factor serum levels for risk stratification and early diagnosis in patients with suspected acute myocardial infarction [PDF]
Aims Angiogenic factors play an important role in the development of atherosclerosis and show pronounced changes during acute myocardial infarction (AMI). We analysed the impact of placental growth factor (PlGF) and its endogen opponent, soluble fms-like
Breidthardt, Tobias +11 more
core
Genetically Encoded Biosensors Reveal PKA Hyperphosphorylation on the Myofilaments in Rabbit Heart Failure [PDF]
RATIONALE: In heart failure, myofilament proteins display abnormal phosphorylation, which contributes to contractile dysfunction. The mechanisms underlying the dysregulation of protein phosphorylation on myofilaments is not clear.
Barbagallo, Federica +15 more
core +1 more source
Background and Objective: Cardiovascular diseases are the most frequent cause of death among hemodialysis patients. Left ventricular hypertrophy and systolic dysfunction are potent predictors of cardiovascular morbidity and mortality in hemodialysis ...
Sedighi O, Golshani S, Nikzad F
doaj
The usefulness of serum troponin levels to predict 1-year survival rates in infective endocarditis
Background and aim: Infective endocarditis (IE) is associated with increased mortality and morbidity. In this study, we aimed to evaluate the role of troponin levels in predicting long-term survival in patients with IE.
Esra Gucuk Ipek +8 more
doaj +1 more source
Gambaran Kadar Troponin T dan Creatinin Kinase Myocardial Band pada Infark Miokard Akut
AbstrakInfark Miokard Akut (IMA) adalah kematian sel miokardium akibat terlepasnya plak aterosklerotik dari salah satu arteri koroner yang mencetuskan terjadinya agregasi trombosit, pembentukan trombus, dan spasme koroner.
Rendi Dwi Prasetyo +2 more
doaj

