Dephosphorylation specificities of protein phosphatase for cardiac troponin I, troponin T, and sites within troponin T [PDF]
Protein dephosphorylation by protein phosphatase 1 (PP1), acting in concert with protein kinase C (PKC) and protein kinase A (PKA), is a pivotal regulatory mechanism of protein phosphorylation.
Nathan M, Jideama +3 more
doaj +4 more sources
Beef muscle troponin: evidence for multiple forms of troponin-t
A method is described for the purification of troponin from beef skeletal muscle. The resultant preparation differs from the troponin of rabbit skeletal muscle in that it contains at least two forms of the tropomyosin-binding component, Troponin-T: these are designated as the 37 000 and 40 000 dalton forms of Troponin-T on the basis of sodium dodecyl ...
Clarke F.M. +3 more
openaire +5 more sources
Renal Elimination of Troponin T and Troponin I [PDF]
Cardiovascular complications represent the predominant cause of death in patients in the terminal stage of renal failure. Increased concentrations of cardiac troponin T (cTnT) may be a valuable predictor of cardiac risk (1)(2). However, cardiac troponin I (cTnI), clinical symptoms, and electrocardiogram (ECG) indications may be absent in patients with ...
Reinhard, Ziebig +10 more
openaire +2 more sources
The Prognostic Significance of Troponin I and Troponin T [PDF]
Abstract. Objectives: To determine and compare the prognostic abilities of early, single‐sample measurements of cardiac troponin I (cTn‐I), cardiac troponin T (cTn‐T), creatine kinase‐MB (CK‐MB) among ED patients with possible myocardial ischemia. Methods: Prospective collection of clinical and serologic data using an identity‐unlinked technique from
G B, Green +5 more
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Location of troponin I‐binding on troponin T sequence [PDF]
Interaction between troponin T and troponin I is considered as one of those necessary for the calI cium-regulatory mechanism in the thin filament of vertebrate striated muscles [ 1,2]. Studies using chymotryptic subfragments of troponin T showed that the affinity for troponin I is localized in the region of the C-terminal 101 residues, termed troponin ...
Tanokura, Masaru, Ohtsuki, Iwao
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False-positive troponin elevation due to an immunoglobulin-G-cardiac troponin T complex: a case report [PDF]
Background Troponin is a crucial biomarker for the diagnosis of an acute coronary syndrome (ACS). It rises in response to myocardial injury from significant acute myocardial ischaemia caused by obstructive coronary artery disease [‘classical’ myocardial
Firoozi, S +11 more
core +1 more source
High-Sensitivity Cardiac Troponin T Variation After Percutaneous Atrial Septal Defect Closure [PDF]
Troponin levels are used to rule in or rule out myocardial injury, with the T and I subunits being the biomarkers of choice. The use of high-sensitivity kits is recommended in clinical practice.1 There are no reference values after percutaneous occlusion
Contreras, Alejandro Ernesto +5 more
core +1 more source
Phosphorylation of the ‘37000 component’ of the troponin complex (troponin-T) [PDF]
Most of the phosphorus present in the troponin complex, which on average contains 1 mol of P/80000g, is associated with the ‘37000 component’ (0.6mol of P/mol). The inhibitory protein and particularly the ‘37000 component’, but not the calcium-binding protein, were phosphorylated when incubated with phosphorylase b kinase and [γ-32P]ATP.
S V, Perry, H A, Cole
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Myocardial injury in noncardiac surgery [PDF]
Myocardial injury is defined as an elevation of cardiac troponin (cTn) levels with or without associated ischemic symptoms. Robust evidence suggests that myocardial injury increases postoperative mortality after noncardiac surgery.
Jungchan Park, Jong-Hwan Lee
doaj +1 more source
To Assess Relationship of Lipoprotein (a) with Severity of Coronary Artery Disease in Patients with Acute Myocardial Infarction: A Hospital based Cross-sectional Study [PDF]
Introduction: Elevated plasma concentrations of lipoprotein {Lp(a)} have been consistently shown to be a risk factor for the development of a spectrum of thrombotic and atherosclerotic disorders including Coronary Artery Disease (CAD). Aim: To assess
Gaurav Bhandari +2 more
doaj +1 more source

